Patents by Inventor Dharmaraj Ramachandra Rao

Dharmaraj Ramachandra Rao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190224192
    Abstract: The present invention relates to novel premixes of Vortioxetine, processes for the preparation of such premixes, pharmaceutical compositions comprising the same and their use in medicine.
    Type: Application
    Filed: August 29, 2017
    Publication date: July 25, 2019
    Inventors: Geena MALHOTRA, Dharmaraj Ramachandra RAO, Venkata Srinivas PULLELA, Preeti RAUT, Shrikant Suresh MUDGAL, Pratap Ramesh SAWANT, Jinesh CHAUHAN, Nidhi BAGREE
  • Patent number: 10328153
    Abstract: There is provided a complex comprising rifaximin and a complexing agent, wherein the complexing agent is a polyvinyl pyrrolidone (PVP) or a cyclodextrin. There is also provided a process for preparing the complex, a pharmaceutical composition including the complex and therapeutic uses of the complex.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: June 25, 2019
    Assignee: Cipla Limited
    Inventors: Maruti Ganpati Ghagare, Sunilkumar Parasnath Saroj, Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan
  • Patent number: 10300044
    Abstract: Amorphous methyl((1S)-1-(((2S)-2-(5-(4?-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl) carbonyl)-2-methylpropyl) carbamate free base, amorphous methyl((1S)-1-(((2S)-2-(5-(4?-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl) carbonyl)-2-methylpropyl) carbamate dihydrochloride, methods of making them, and pharmaceutical compositions containing them.
    Type: Grant
    Filed: December 24, 2015
    Date of Patent: May 28, 2019
    Assignee: Cipla Limited
    Inventors: Dharmaraj Ramachandra Rao, Geena Malhotra, Manjinder Singh Phull, Shashirekha Kanathala, Manish Gopaldas Gangrade
  • Patent number: 10301282
    Abstract: The present invention relates to a novel polymorph of nilotinib hydrochloride (Form X), to processes for its preparation, to pharmaceutical compositions containing the same and to its use in medicine.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: May 28, 2019
    Assignee: Cipla Limited
    Inventors: Dharmaraj Ramachandra Rao, Geena Malhotra, Srinivas Laxminarayan Pathi, Venugopalarao Chinimilli, Manish Gopaldas Gangrade
  • Patent number: 10287248
    Abstract: The present invention relates to novel processes for the preparation of apremilast of formula I, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 15, 2016
    Date of Patent: May 14, 2019
    Assignee: CIPLA LIMITED
    Inventors: Dharmaraj Ramachandra Rao, Geena Malhotra, Srinivas Laxminarayan Pathi, Ravikumar Puppala, Suryanarayana Durga Yarra
  • Publication number: 20190055278
    Abstract: The present invention relates to an improved process for the preparation of Linaclotide of Formula I. The process disclosed in the present invention is simple, economical and eco-friendly with reduced reaction times.
    Type: Application
    Filed: February 3, 2017
    Publication date: February 21, 2019
    Inventors: Dharmaraj Ramachandra RAO, Geena MALHOTRA, Venkata Srinivas PULLELA, Parag Shankar KURLE, Rakesh MENDHE
  • Patent number: 10208058
    Abstract: The present invention discloses a novel process for the preparation of macrocyclic ketone analogs of halichondrin B or pharmaceutically acceptable salts thereof and to novel intermediates which are produced during the course of carrying out the novel process.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: February 19, 2019
    Assignee: CIPLA LIMITED
    Inventors: Dharmaraj Ramachandra Rao, Geena Malhotra, Venkata Srinivas Pullela, Vinod Parameshwaran Acharya, Nagarjuna Reddy Vantadou
  • Publication number: 20180289817
    Abstract: There is provided a complex comprising rifaximin and a complexing agent, wherein the complexing agent is a polyvinyl pyrrolidone (PVP) or a cyclodextrin. There is also provided a process for preparing the complex, a pharmaceutical composition including the complex and therapeutic uses of the complex.
    Type: Application
    Filed: June 11, 2018
    Publication date: October 11, 2018
    Applicant: Cipla Limited
    Inventors: Maruti Ganpati Ghagare, Sunilkumar Parasnath Saroj, Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan
  • Publication number: 20180237390
    Abstract: The present invention relates to novel processes for the preparation of apremilast of formula I, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 15, 2016
    Publication date: August 23, 2018
    Inventors: Dharmaraj Ramachandra RAO, Geena MALHOTRA, Srinivas Laxminarayan PATHI, Ravikumar PUPPALA, Suryanarayana Durga YARRA
  • Publication number: 20180235944
    Abstract: Amorphous rifaximin, methods of making it, and pharmaceutical compositions containing it. Also described are methods of converting amorphous rifaximin to crystalline rifaximin and vice versa.
    Type: Application
    Filed: January 17, 2018
    Publication date: August 23, 2018
    Applicant: CIPLA Limited
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Manjinder Singh Phull, Muruti Ghagare
  • Patent number: 10023611
    Abstract: A novel and improved process for preparation of bortezomib mannitol ester is derived, which process avoids excessive use of solvents, involves convenient, industrially feasible and economical techniques, and provides improvements in purity over processes known in the art.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: July 17, 2018
    Assignee: Cipla Limited
    Inventors: Ravikumar Puppala, Srinivas Laxminarayan Pathi, Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan
  • Patent number: 9993560
    Abstract: There is provided a complex comprising rifaximin and a complexing agent, wherein the complexing agent is a polyvinyl pyrrolidone (PVP) or a cyclodextrin. There is also provided a process for preparing the complex, a pharmaceutical composition including the complex and therapeutic uses of the complex.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: June 12, 2018
    Assignee: CIPLA Limited
    Inventors: Maruti Ganpati Ghagare, Sunilkumar Parasnath Saroj, Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan
  • Patent number: 9993561
    Abstract: There is provided a complex comprising rifaximin and a complexing agent, wherein the complexing agent is a polyvinyl pyrrolidone (PVP) or a cyclodextrin. There is also provided a process for preparing the complex, a pharmaceutical composition including the complex and therapeutic uses of the complex.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: June 12, 2018
    Assignee: CIPLA Limited
    Inventors: Maruti Ganpati Ghagare, Sunilkumar Parasnath Saroj, Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan
  • Publication number: 20180111915
    Abstract: The present invention relates to a novel polymorph of nilotinib hydrochloride (Form X), to processes for its preparation, to pharmaceutical compositions containing the same and to its use in medicine.
    Type: Application
    Filed: March 21, 2016
    Publication date: April 26, 2018
    Applicant: Cipla Limited
    Inventors: Dharmaraj Ramachandra RAO, Geena MALHOTRA, Srinivas Laxminarayan PATHI, Venugopalarao CHINIMILLI, Manish Gopaldas GANGRADE
  • Patent number: 9938297
    Abstract: The present invention relates to a novel process for the synthesis of everolimus of formula (I): and intermediates thereof.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: April 10, 2018
    Assignee: Cipia Limited
    Inventors: Dharmaraj Ramachandra Rao, Geena Malhotra, Venkata Srinivas Pullela, Vinod Parameshwaran Acharya
  • Publication number: 20180072690
    Abstract: The present invention relates to a process for preparing serotonin reuptake inhibitors of formula (I) and pharmaceutically acceptable salts thereof, (Formula (I)) wherein, R1, R2, R3, l, m, n and Z are as defined in the specification.
    Type: Application
    Filed: March 23, 2016
    Publication date: March 15, 2018
    Applicant: CIPLA Limited
    Inventors: Dharmaraj Ramachandra Rao, Geena Malhotra, Venkata Srinivas Pullela, Shrikant Suresh Mudgal
  • Patent number: 9877953
    Abstract: Amorphous rifaximin, methods of making it, and pharmaceutical compositions containing it. Also described are methods of converting amorphous rifaximin to crystalline rifaximin and vice versa.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: January 30, 2018
    Assignee: CIPLA LIMITED
    Inventors: Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan, Manjinder Singh Phull, Maruti Ghagare
  • Publication number: 20170354644
    Abstract: Amorphous methyl((1S)-1-(((2S)-2-(5-(4?-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl) carbonyl)-2-methylpropyl) carbamate free base, amorphous methyl((1S)-1-(((2S)-2-(5-(4?-(2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl) carbonyl)-2-methylpropyl) carbamate dihydrochloride, methods of making them, and pharmaceutical compositions containing them.
    Type: Application
    Filed: December 24, 2015
    Publication date: December 14, 2017
    Inventors: Dharmaraj Ramachandra RAO, Geena MALHOTRA, Manjinder Singh PHULL, Shashirekha KANATHALA, Manish Gopaldas GANGRADE
  • Publication number: 20170267669
    Abstract: The present invention relates to an environmentally friendly process for preparing rivaroxaban. The present invention provides a process for preparing rivaroxaban of formula I, the process comprising: reacting a compound of formula VI with a base in the presence of a solvent to form a compound of formula VII; and condensing the compound of formula VII with a compound of formula VIII or a compound of formula IX in the presence of a solvent to prepare rivaroxaban of formula I, wherein the solvent used in both steps comprises water.
    Type: Application
    Filed: August 24, 2015
    Publication date: September 21, 2017
    Inventors: Dharmaraj Ramachandra RAO, Geena MALHOTRA, Venkata Srinivas PULLELA, Manohar Raghunath SURVE, Hemant Sanjeevan DORLE, Kiran Balasaheb JADHAV
  • Publication number: 20170240561
    Abstract: The present invention discloses a novel process for the preparation of macrocyclic ketone analogs of halichondrin B or pharmaceutically acceptable salts thereof and to novel intermediates which are produced during the course of carrying out the novel process.
    Type: Application
    Filed: September 9, 2015
    Publication date: August 24, 2017
    Inventors: Dharmaraj Ramachandra RAO, Geena MALHOTRA, Venkata Srinivas PULLELA, Vinod Parameshwaran ACHARYA, Nagarjuna Reddy VANTADOU