Patents by Inventor Diana Clare Hargreaves

Diana Clare Hargreaves has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for identifying and treating cancer patients
    Patent number: 10976320
    Abstract: Methods for identifying and treating cancer patients likely to respond to topoisomerase inhibitors or likely to fail to respond to topoisomerase inhibitors are provided. The methods take advantage of the newly discovered role of BAF complexes in decatenation of DNA by topoisomerase IIa. Cancer cells are frequently at least partly defective in BAF complex activity. Such cells are targeted for therapy using certain topoisomerase IIa inhibitors according to the disclosed methods of treatment. Therapy of such cells using other topoisomerase inhibitors should be avoided.
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: April 13, 2021
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Emily Carla Dykhuizen, Diana Clare Hargreaves, Cigall Kadoch, Gerald R. Crabtree
  • METHODS FOR IDENTIFYING AND TREATING CANCER PATIENTS
    Publication number: 20150185221
    Abstract: Methods for identifying and treating cancer patients likely to respond to topoisomerase inhibitors or likely to fail to respond to topoisomerase inhibitors are provided. The methods take advantage of the newly discovered role of BAF complexes in decatenation of DNA by topoisomerase IIa. Cancer cells are frequently at least partly defective in BAF complex activity. Such cells are targeted for therapy using certain topoisomerase IIa inhibitors according to the disclosed methods of treatment. Therapy of such cells using other topoisomerase inhibitors should be avoided.
    Type: Application
    Filed: May 21, 2014
    Publication date: July 2, 2015
    Inventors: Emily Carla Dykhuizen, Diana Clare Hargreaves, Cigall Kadoch, Gerald R. Crabtree