Patents by Inventor Didier Letourneur

Didier Letourneur has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10588861
    Abstract: The present inventions relates to beads as biocompatible material adapted for use within the human or animal body. Said beads are highly useful for tissue engineering, in situ tissue regeneration, as well as for drug and/or cells delivery. In addition, said beads may support biotechnological applications such as cell carriers.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: March 17, 2020
    Assignees: Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Diderot—Paris 7
    Inventors: Didier Letourneur, Catherine Le Visage, Sidi Mohammed Derkaoui
  • Publication number: 20200016294
    Abstract: The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprises the steps consisting of: a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide, an amount of a cross-linking agent and an amount of a porogen agent b) transforming the solution into a hydrogel by placing said solution at a temperature from about 4° C. to about 80° C. for a sufficient time to allow the cross-linking of said amount of polysaccharide and c) submerging said hydrogel into an aqueous solution d) washing the porous scaffold obtained at step c).
    Type: Application
    Filed: March 25, 2019
    Publication date: January 16, 2020
    Inventors: Catherine Le Visage, Didier Letourneur
  • Publication number: 20190275195
    Abstract: The present invention relates to methods for adhering tissue surfaces and materials and biomedical uses thereof. In particular the present invention relates to a method for adhering a first tissue surface to a second tissue surface in a subject in need thereof, comprising the steps of adsorbing a layer of nanoparticles on at least one of the tissue surfaces, and approximating the surfaces for a time sufficient for allowing the surfaces to adhere to each other. The present invention also relates to a method for adhering a material to a biological tissue in a subject in need thereof, comprising the steps of adsorbing a layer of nanoparticles on the surface of the material and/or the biological tissue and approximating the material and the biological tissue for a time sufficient for allowing the material and the biological tissue to adhere to each other.
    Type: Application
    Filed: April 1, 2019
    Publication date: September 12, 2019
    Inventors: Ludwik LEIBLER, Anne MEDDAHI-PELLÉ, Didier LETOURNEUR, Alba MARCELLAN-PARISOT
  • Patent number: 10286101
    Abstract: The present invention relates to methods for adhering tissue surfaces and materials and biomedical uses thereof. In particular the present invention relates to a method for adhering a first tissue surface to a second tissue surface in a subject in need thereof, comprising the steps of adsorbing a layer of nanoparticles on at least one of the tissue surfaces, and approximating the surfaces for a time sufficient for allowing the surfaces to adhere to each other. The present invention also relates to a method for adhering a material to a biological tissue in a subject in need thereof, comprising the steps of adsorbing a layer of nanoparticles on the surface of the material and/or the biological tissue and approximating the material and the biological tissue for a time sufficient for allowing the material and the biological tissue to adhere to each other.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: May 14, 2019
    Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale), Université Paris Diderot—Paris 7, Centre National de la Recherche Scientifique (CNRS), Université Paris XIII Paris-Nord, École Supérieur de Physique et de Chimie Industrielles de Paris
    Inventors: Ludwik Leibler, Anne Meddahipelle, Didier Letourneur, Alba Marcellan-Parisot
  • Publication number: 20190083400
    Abstract: The present inventions relates to beads as biocompatible material adapted for use within the human or animal body. Said beads arc highly useful for tissue engineering, in situ tissue regeneration, as well as for drug and/or cells delivery. In addition, said beads may support biotechnological applications such as cell carriers.
    Type: Application
    Filed: November 21, 2018
    Publication date: March 21, 2019
    Inventors: Didier Letourneur, Catherine Le Visage, Sidi Mohammed Derkaoui
  • Patent number: 10143774
    Abstract: The present invention relate to three dimensional porous polysaccharide matrices able to induce mineralization of a tissue in osseous site, as well as in non-osseous site, in the absence of stem cells or growth factors.
    Type: Grant
    Filed: July 24, 2017
    Date of Patent: December 4, 2018
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITE DE BORDEAUX II VICTOR SEGALEN, UNIVERSITÉ PARIS DIDEROT—PARIS 7
    Inventors: Joelle Amedee, Didier Letourneur, Catherine Le Visage, Sidi Mohammed Derkaoui, Jean-Christophe Fricain, Sylvain Catros
  • Patent number: 9999679
    Abstract: The invention relates to a vector targeting thrombus, having t-PA binding property consisting of a thrombus targeting fucoidan moiety, which is covalently linked to one or more t-PA binding amino groups by the reducing end of the said fucoidan moiety.
    Type: Grant
    Filed: March 21, 2014
    Date of Patent: June 19, 2018
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE PARIS XIII PARIS NORD, UNIVERSITE PARIS DIDEROT—PARIS 7
    Inventors: Stephane Loyau, Martine Jandrot-Perrus, Didier Letourneur, Frederic Chaubet, Benoit Ho-Tin-Noe, Murielle Maire, Jean-Baptiste Michel
  • Publication number: 20170319741
    Abstract: The present invention relate to three dimensional porous polysaccharide matrices able to induce mineralisation of a tissue in osseous site, as well as in non-osseous site, in the absence of stem cells or growth factors.
    Type: Application
    Filed: July 24, 2017
    Publication date: November 9, 2017
    Applicants: Institut National de la Sante et de la Recherche Medicale (INSERM), Universite de Bordeaux II Victor Segalen, Universite Paris Diderot - Paris 7
    Inventors: Joelle Amedee, Didier Letourneur, Catherine Le Visage, Sidi Mohammed Derkaoui, Jean-Christophe Fricain, Sylvain Catros
  • Patent number: 9757494
    Abstract: The present invention relate to three dimensional porous polysaccharide matrices able to induce mineralisation of a tissue in osseous site, as well as in non-osseous site, in the absence of stent cells or growth factors.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: September 12, 2017
    Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Universite de Bordeaux II Victor Segalen, Universite Paris Diderot-Paris 7
    Inventors: Joelle Amedee, Didier Letourneur, Catherine Le Visage, Sidi Mohammed Derkaoui, Jean-Christophe Fricain, Sylvain Catros
  • Publication number: 20170080123
    Abstract: The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprises the steps consisting of: a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide, an amount of a cross-linking agent and an amount of a porogen agent b) transforming the solution into a hydrogel by placing said solution at a temperature from about 4° C. to about 80° C. for a sufficient time to allow the cross-linking of said amount of polysaccharide and c) submerging said hydrogel into an aqueous solution d) washing the porous scaffold obtained at step c).
    Type: Application
    Filed: November 9, 2016
    Publication date: March 23, 2017
    Inventors: Catherine Le Visage, Didier Letourneur
  • Patent number: 9555164
    Abstract: The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprise the steps consisting of a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide and one cross-linking agent b) freezing the aqueous solution of step a) c) sublimating the frozen solution of step b) characterized in that step b) is performed before the cross-linking of the polysaccharide occurs in the solution of step a).
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: January 31, 2017
    Assignee: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Catherine Le Visage, Didier Letourneur, Frederic Chaubet, Aude Autissier
  • Patent number: 9522218
    Abstract: The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprises the steps consisting of: a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide, an amount of a cross-linking agent and an amount of a porogen agent b) transforming the solution into a hydrogel by placing said solution at a temperature from about 4° C. to about 80° C. for a sufficient time to allow the cross-linking of said amount of polysaccharide and c) submerging said hydrogel into an aqueous solution d) washing the porous scaffold obtained at step c).
    Type: Grant
    Filed: October 10, 2008
    Date of Patent: December 20, 2016
    Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale), Université Paris 7—Denis Diderot
    Inventors: Catherine Le Visage, Didier Letourneur
  • Patent number: 9521839
    Abstract: The present invention provides a method for cryoprotecting a biological specimen comprising the step of freezing said biological specimen in the presence of a hydrogel and in the absence of cryoprotectant.
    Type: Grant
    Filed: January 17, 2013
    Date of Patent: December 20, 2016
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE PARIS DESCARTES (PARIS V), UNIVERSITE DE VERSAILLES—SAINT QUENTIN EN YVELINES
    Inventors: Anne Pelle Meddahi, Aicha Abed, Didier Letourneur, Anne Baudot
  • Publication number: 20160325010
    Abstract: The present invention relates to methods for adhering tissue surfaces and materials and biomedical uses thereof. In particular the present invention relates to a method for adhering a first tissue surface to a second tissue surface in a subject in need thereof, comprising the steps of adsorbing a layer of nanoparticles on at least one of the tissue surfaces, and approximating the surfaces for a time sufficient for allowing the surfaces to adhere to each other. The present invention also relates to a method for adhering a material to a biological tissue in a subject in need thereof, comprising the steps of adsorbing a layer of nanoparticles on the surface of the material and/or the biological tissue and approximating the material and the biological tissue for a time sufficient for allowing the material and the biological tissue to adhere to each other.
    Type: Application
    Filed: December 10, 2014
    Publication date: November 10, 2016
    Applicant: INSERM (Institut National de la Sante et de la Recherche Medicale)
    Inventors: Ludwik LIEBLER, Anne MEDDAHIPELLE, Didier LETOURNEUR
  • Publication number: 20160279249
    Abstract: The invention relates to a vector targeting thrombus, having t-PA binding property consisting of a thrombus targeting fucoidan moiety, which is covalently linked to one or more t-PA binding amino groups by the reducing end of the said fucoidan moiety.
    Type: Application
    Filed: March 21, 2014
    Publication date: September 29, 2016
    Applicants: INSTITUT DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE PARIS XIII PARIS NORD, UNIVERSITE PARIS DIDEROT - PARIS 7
    Inventors: Stephane LOYAU, Martine JANDROT-PERRUS, Didier LETOURNEUR, Frederic CHAUBET, Benoit HO-TIN-NOE, Murielle MAIRE, Jean-Baptiste MICHEL
  • Publication number: 20160279064
    Abstract: The present inventions relates to beads as biocompatible material adapted for use within the human or animal body. Said beads are highly useful for tissue engineering, in situ tissue regeneration, as well as for drug and/or cells delivery. In addition, said beads may support biotechnological applications such as cell carriers.
    Type: Application
    Filed: June 3, 2016
    Publication date: September 29, 2016
    Inventors: Didier Letourneur, Catherine Le Visage, Sidi Mohammed Derkaoui
  • Patent number: 9381250
    Abstract: The present inventions relates to beads as biocompatible material adapted for use within the human or animal body. Said beads are highly useful for tissue engineering, in situ tissue regeneration, as well as for drug and/or cells delivery. In addition, said beads may support biotechnological applications such as cell carriers.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: July 5, 2016
    Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Universite Paris Diderot—Paris 7
    Inventors: Didier Letourneur, Catherine Le Visage, Sidi Mohammed Derkaoui
  • Publication number: 20150328365
    Abstract: The present invention relate to three dimensional porous polysaccharide matrices able to induce mineralisation of a tissue in osseous site, as well as in non-osseous site, in the absence of stent cells or growth factors.
    Type: Application
    Filed: June 2, 2015
    Publication date: November 19, 2015
    Applicants: Institut National de la Sante et de la Recherche Medicale (INSERM), Universite de Bordeaux II Victor Segalen, Universite Paris Diderot - Paris 7
    Inventors: Joelle AMEDEE, Didier LETOURNEUR, Catherine LE VISAGE, Sidi Mohammed DERKAOUI, Jean-Christophe FRICAIN, Sylvain CATROS
  • Publication number: 20150246163
    Abstract: The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprise the steps consisting of a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide and one cross-linking agent b) freezing the aqueous solution of step a) c) sublimating the frozen solution of step b) characterized in that step b) is performed before the cross-linking of the polysaccharide occurs in the solution of step a).
    Type: Application
    Filed: May 11, 2015
    Publication date: September 3, 2015
    Inventors: Catherine Le Visage, Didier Letourneur, Frederic Chaubet, Aude Autissier
  • Patent number: 9028857
    Abstract: The present invention relates to a method for preparing a porous scaffold for tissue engineering. It is another object of the present invention to provide a porous scaffold obtainable by the method as above described, and its use for tissue engineering, cell culture and cell delivery. The method of the invention comprise the steps consisting of a) preparing an alkaline aqueous solution comprising an amount of at least one polysaccharide and one cross-linking agent b) freezing the aqueous solution of step a) c) sublimating the frozen solution of step b). characterized in that step b) is performed before the cross-linking of the polysaccharide occurs in the solution of step a).
    Type: Grant
    Filed: October 10, 2008
    Date of Patent: May 12, 2015
    Assignees: INSERM (Institut National de la Sante et de la Recherche Medicale), Universite Paris 7—Denis Diderot
    Inventors: Catherine Le Visage, Didier Letourneur, Frederic Chaubet, Aude Autissier