Abstract: The present invention relates to a pharmaceutical composition comprising at least one peptide consisting of a minimum of 8 and a maximum of 50 amino acid residues comprising amino acid residues 1 to 8 of a rhinovirus capsid protein selected from the group consisting of VP1, VP2, VP3 and VP4.

Abstract: The present invention relates to a pharmaceutical composition comprising at least one peptide consisting of a minimum of 8 and a maximum of 50 amino acid residues comprising amino acid residues 1 to 8 of a rhinovirus capsid protein selected from the group consisting of VP1, VP2, VP3 and VP4.

Abstract: Methods of making and using Picornavirus L proteinase peptides (PLPPs) are provided, including, but not limited to, expression of DNA encoding all or a portion thereof, such as a Picornavirus L proteinase (PLP) and variants thereof, as well as methods for determining active sites and inhibitors of a PLP.

Abstract: A substantially pure receptor with binding activity for rhinoviruses of the minor human receptor group is disclosed, which has the following characteristics:(a) a molecular weight of 120 kD on a polyacrylamide gel in the presence of SDS;(b) a sedimentation constant, determined by sucrose gradient centrifugation in the presence of detergents, corresponding to about 28.4 S;(c) is bound by Lens culinaris lectin;(d) is not bound by heparin-sepharose;(e) is bound irreversibly to an anion exchanger;(f) has binding activity which is insensitive to neuraminidase;(g) consists of sub-units connected by intermolecular disulfide bridges;(h) shows no binding activity to rhinoviruses in the presence of EDTA; and(i) has a binding activity to rhinoviruses which is only slightly influenced by iodoacetamide.Methods of providing protection against infection by rhinoviruses of the minor receptor group with the substantially pure receptor of the present invention, are also disclosed.

Abstract: A substantially pure receptor with binding activity for rhinoviruses of the minor human receptor group is disclosed, which has the following characteristics:(a) a molecular weight of 120 kD on a polyacrylamide gel in the presence of SDS;(b) a sedimentation constant, determined by sucrose gradient centrifugation in the presence of detergents, corresponding to about 28.4 S;(c) is bound by Lens culinaris lectin;(d) is not bound by heparin-sepharose;(e) is bound irreversibly to an anion exchanger;(f) has binding activity which is insensitive to neuraminidase;(g) consists of sub-units connected by intermolecular disulfide bridges;(h) shows no binding activity to rhinoviruses in the presence of EDTA; and(i) has a binding activity to rhinoviruses which is only slightly influenced by iodoacetamide.A receptor subunit of the above-described receptor, produced by complete reduction of said receptor, is also disclosed.

Abstract: The invention relates to the expression of mature HRV proteinase 2A, the partial purification thereof and the preparation of substrates having an inhibitory effect.

Abstract: A substantially pure receptor with binding activity for rhinoviruses of the small receptor group is disclosed, which has the following characteristics:(a) a molecular weight of 120 kD on a polyacrylamide gel in the presence of SDS;(b) a sedimentation constant, determined by sucrose gradient centrifugation in the presence of detergents, corresponding to about 28.4 S;(c) is bound by Lens culinaris lectin;(d) is not bound by heparin-sepharose;(e) is bound irreversibly to an anion exchanger;(f) has binding activity which is insensitive to neuraminidase;(g) consists of sub-units connected by intermolecular disulfide bridges;(h) shows no binding activity to rhinoviruses in the presence of EDTA; and(i) has a binding activity to rhinoviruses which is only slightly influenced by iodoacetamide.A receptor subunit of the above-described receptor, produced by complete reduction of said receptor, is also disclosed.

Abstract: The present invention relates to a method of characterizing viruses and the use thereof for classification. According to the invention, a cDNA copy of a first virus is made and the cDNA is amplified and cleaved using at least one restriction endonuclease. The location of restriction fragments is mapped and compared to that of other viruses. Primers useful for amplifying the cDNA may be derived from sequences found in the 5' non-coding regions of picornavirus including human rhinovirus.

Abstract: A substantially pure receptor with binding activity for rhinoviruses of the small receptor group is disclosed, which has the following characteristics:(a) a molecular weight of 120 KD on a polyacrylamide gel in the presence of SDS;(b) a sedimentation constant, determined by sucrose gradient centrifugation in the presence of detergents, corresponding to about 28.4 S;(c) is bound by Lens culinaris lectin;(d) is not bound by heparin-sepharose;(e) is bound irreversibly to an anion exchanger;(f) has binding activity which is insensitive to neuraminidase;(g) consists of sub-units connected by intermolecular disulfide bridges;(h) shows no binding activity to rhinoviruses in the presence of EDTA; and(i) has a binding activity to rhinoviruses which is only slightly influenced by iodoacetamide.A receptor subunit of the above-described receptor, produced by complete reduction of said receptor, is also disclosed.

Abstract: This invention relates to a DNA molecule or a functional derivative thereof coding for a fusion protein, the fusion protein comprising an enzymatically active component and a non-enzymatically active polypeptide component which may be cleaved therefrom, an expression system which contains the DNA molecule, the use thereof as a test system for inhibitors of viral proteases, and an assay for identifying viral inhibitors.