Patents by Inventor Dieter Lenke

Dieter Lenke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5370877
    Abstract: .alpha.-Aminocarboxylic acid derivatives of the formula: ##STR1## where n, X, Y and Z have the meanings stated in the description, and their preparation are described. The compounds are used in a method for improving delivery and reducing toxicity of biologically active substances by encapsulation of the biologically active substance with the above compounds.
    Type: Grant
    Filed: March 31, 1993
    Date of Patent: December 6, 1994
    Assignee: Knoll AG
    Inventors: Joerg Rosenberg, Hans-Heinrich Gruenhagen, Dieter Lenke
  • Patent number: 5118685
    Abstract: Aminopropanol derivatives of the formula: ##STR1## where R.sup.1 and R.sup.2 are identical or different and are each hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl or hydroxyalkyl, each of not more than 6 carbon atoms, alkoxyalkyl, alkylthioalkyl or dialkylaminoalkyl, each of not more than 9 carbon atoms in total, or phenylalkyl or phenoxyalkyl where the alkyl radical is of not more than 6 carbon atoms and the phenyl radical is unsubstituted or substituted by alkyl or alkoxy, each of not more than 3 carbon atoms, or R.sup.1 and R.sup.2, together with the nitrogen atom which links them, form a 5-membered to 7-membered saturated heterocyclic ring which can be substituted by one or two phenyl and/or hydroxyl radicals and can contain an oxygen or nitrogen atom, as a further heteroatom in the ring, and such an additional nitrogen atom can be substituted by alkyl of 1 to 3 carbon atoms or by phenyl, and -- .circle.
    Type: Grant
    Filed: December 3, 1984
    Date of Patent: June 2, 1992
    Assignee: BASF Aktiengesellschaft
    Inventors: Albrecht Franke, Wolfgang Spiegler, Hardo Siegel, Claus D. Mueller, Gerda von Philipsborn, Dieter Lenke, Josef Gries
  • Patent number: 4873246
    Abstract: Novel 6-(acylaminaryl)-3(2H)-pyridazinones of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, A and B have the meanings given in the description, and their preparation are described.The compounds have thrombocyte aggregation-inhibiting activity.
    Type: Grant
    Filed: October 8, 1986
    Date of Patent: October 10, 1989
    Assignee: BASF Aktiengesellschaft
    Inventors: Philip A. Rossy, Marco Thyes, Albrecht Franke, Horst Koenig, Hans D. Lehmann, Josef Gries, Ludwig Friedrich, Dieter Lenke
  • Patent number: 4777183
    Abstract: Anipamil and its salts with physiologically tolerated acids are used for the preparation of drugs having antiarteriosclerotic properties and in the treatment of arteriosclerosis.
    Type: Grant
    Filed: October 5, 1987
    Date of Patent: October 11, 1988
    Assignee: Knoll AG
    Inventors: Dieter Lenke, Claus D. Mueller
  • Patent number: 4723039
    Abstract: Phenylacetaldehydes which are substituted by basic groups, of the formula ##STR1## where R.sup.1 to R.sup.8, m and n have the meanings stated in the description, and their preparation are described. The substances are useful for the treatment of disorders.
    Type: Grant
    Filed: December 4, 1986
    Date of Patent: February 2, 1988
    Assignee: BASF Aktiengesellschaft
    Inventors: Werner Seitz, Verena Baldinger, Josef Gries, Dieter Lenke, Manfred Raschack, Klaus Ruebsamen
  • Patent number: 4670435
    Abstract: 10,11-Dihydro-5H-dibenzo[a,d]cycloheptadiene derivatives of the formula I ##STR1## where R.sup.1 and R.sup.2 have the meanings stated in the description, and their preparation are described. The novel substances are useful for the treatment of disorders.
    Type: Grant
    Filed: December 2, 1985
    Date of Patent: June 2, 1987
    Assignee: BASF Aktiengesellschaft
    Inventors: Albrecht Franke, deceased, Claus D. Mueller, Dieter Lenke
  • Patent number: 4636504
    Abstract: Novel 6-(acylaminoaryl)-3(2H)-pyridazinones of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, A and B have the meanings given in the description, and their preparation are described and inhibiting thrombocyte aggregation and gastric secretion.The compounds are useful for treating disorders.
    Type: Grant
    Filed: January 17, 1984
    Date of Patent: January 13, 1987
    Assignee: BASF Aktiengesellschaft
    Inventors: Phillip A. Rossy, Marco Thyes, Albrecht Franke, Horst Koenig, Hans Dieter Lehmann, Josef Gries, Ludwig Friedrich, Dieter Lenke
  • Patent number: 4619929
    Abstract: Novel phenylpiperazinylpropane and -butane derivatives of hetarylphenols and hetarylanilines of the formula ##STR1## where R.sup.1 is hydrogen or alkyl of 1 to 4 carbon atoms, R.sup.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy where alkyl is of 1 to 3 carbon atoms, the phenyl ring can be monosubstituted or disubstituted by R.sup.2, X is oxygen or an NH group, and the heterocyclic structure Het. is 1,3,4-oxadiazolyl, triazolyl, imidazolyl or pyrazolyl, and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and exhibit predominantly sedative, neuroleptic and hypotensive properties.
    Type: Grant
    Filed: March 19, 1984
    Date of Patent: October 28, 1986
    Assignee: BASF Aktiengesellschaft
    Inventors: Peter C. Thieme, Gerd Steiner, Wolfgang Rohr, Dieter Lenke, Josef Gries, Harald Weifenbach, Hans-Juergen Teschendorf, Hans P. Hofmann, Horst Kreiskott
  • Patent number: 4618622
    Abstract: Sulfonates of hydroxycoumarins of the formula I ##STR1## where R.sup.1 and R.sup.2 are identical or different and are each hydrogen, halogen or alkyl of 1 to 5 carbon atoms which can be substituted by --NR.sup.4 R.sup.5, --OR.sup.4 or --OC(O)R.sup.4, where R.sup.4 and R.sup.5 are identical or different and are each hydrogen or alkyl of 1 to 4 carbon atoms, or R.sup.1 and R.sup.2 are each a carboxylic acid group --OC(O)R.sup.4 or a carboxamido radical, with the proviso that R.sup.1 is not methyl when R.sup.2 is hydrogen, or R.sup.1 and R.sup.2 together form a --(CH.sub.2).sub.n -- chain where n is 3-5, and R.sup.3 is a straight-chain or branched alkyl radical of 1 to 8 carbon atoms or cycloalkyl of 3 to 8 carbon atoms, each of which can be substituted by halogen, --OR.sup.4, --NR.sup.4 R.sup.5, --CN or phenyl, or R.sup.3 is a straight-chain or branched alkenyl radical of 3 to 8 carbon atoms, an amino group -- NR.sup.4 R.sup.
    Type: Grant
    Filed: November 17, 1983
    Date of Patent: October 21, 1986
    Assignee: BASF Aktiengesellschaft
    Inventors: Rainer Schlecker, Peter Schmidt, Peter C. Thieme, Dieter Lenke, Hans-Jurgen Teschendorf, Martin Traut, Claus D. Mueller, Hans P. Hofmann, Horst Kreiskott
  • Patent number: 4612320
    Abstract: Compounds of the general formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4 and n have the meanings given in the description, are useful for treating cardiac disorders.
    Type: Grant
    Filed: March 12, 1984
    Date of Patent: September 16, 1986
    Assignee: BASF Aktiengesellschaft
    Inventors: Albrecht Franke, Josef Gries, Claus D. Mueller, Dieter Lenke
  • Patent number: 4575508
    Abstract: 2-Substituted 1-(3'-aminoalkyl)-1,2,3,4-tetrahydro-.beta.-carbolines of the formula ##STR1## where n, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the meanings given in the description, and their preparation and use.The novel substances are useful for treating arrhythmia.
    Type: Grant
    Filed: August 5, 1983
    Date of Patent: March 11, 1986
    Assignee: BASF Aktiengesellschaft
    Inventors: Gerd Steiner, Claus D. Mueller, Dieter Lenke
  • Patent number: 4571409
    Abstract: Novel aminopropanol derivatives of 2-hydroxy-.beta.-phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.
    Type: Grant
    Filed: May 13, 1985
    Date of Patent: February 18, 1986
    Assignee: BASF Aktiengesellschaft
    Inventors: Albrecht Franke, Josef Mueller, Helmut Lietz, Walter-Wielant Wiersdorff, Hans-Guenther Hege, Claus D. Mueller, Josef Gries, Dieter Lenke, Gerda von Philipsborn, Manfred Raschack
  • Patent number: 4548933
    Abstract: 10-Substituted 5-cyanomethylene-dibenzo[a,d]-cycloheptenes, their pure cis- and trans-isomers, their N-oxides and their pharmaceutically tolerated addition salts with acids, processes for their preparation, therapeutic agents containing these compounds and their use as drugs, especially as sedatives, hypnotics or tranquilizers.
    Type: Grant
    Filed: December 13, 1983
    Date of Patent: October 22, 1985
    Assignee: BASF Aktiengesellschaft
    Inventors: Gerd Steiner, Hans P. Hofmann, Horst Kreiskott, Hans-Juergen Teschendorf, Dieter Lenke
  • Patent number: 4544562
    Abstract: 6-Aryl-4,5-dihydro-3(2H)-pyridazinones of the formula ##STR1## where R is hydrogen, R.sup.1 is hydrogen or C.sub.1 -C.sub.3 -alkyl, or R and R.sup.1 together are methylene, R.sup.2 and R.sup.3 are identical or different and are each hydrogen or C.sub.1 -C.sub.6 -alkyl, and A is hydroxyl, C.sub.1 -C.sub.6 -alkoxy, C.sub.2 -C.sub.7 -acyloxy, a C.sub.2 -C.sub.7 -carbamic acid ester group, C.sub.1 -C.sub.6 -alkylsulfonyloxy, C.sub.1 -C.sub.6 -alkylmercapto, carboxyl, C.sub.2 -C.sub.7 -alkoxycarbonyl or nitrile, and their preparation are described. The substances are suitable for treating disorders.
    Type: Grant
    Filed: March 11, 1983
    Date of Patent: October 1, 1985
    Assignee: BASF Aktiengesellschaft
    Inventors: Phillip A. Rossy, Marco Thyes, Albrecht Franke, Horst Koenig, Josef Gries, Hans D. Lehmann, Dieter Lenke
  • Patent number: 4540697
    Abstract: Novel aminopropanol derivatives of 2-hydroxy-.beta.-phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.
    Type: Grant
    Filed: May 23, 1984
    Date of Patent: September 10, 1985
    Assignee: BASF Aktiengesellschaft
    Inventors: Albrecht Franke, Josef Muller, Helmut Lietz, Walter-Wielant Wiersdorff, Hans-Gunther Hege, Claus D. Muller, Josef Gries, Dieter Lenke, Gerda von Philipsborn, Manfred Raschack
  • Patent number: 4517196
    Abstract: Thiazolyloxamic acids and their derivatives of the general formula I ##STR1## processes for their preparation, and pharmaceutical formulations which contain these compounds and are useful as drugs for treating allergic disorders.
    Type: Grant
    Filed: August 26, 1982
    Date of Patent: May 14, 1985
    Assignee: BASF Aktiengesellschaft
    Inventors: Rainer Schlecker, Ludwig Friedrich, Dieter Lenke
  • Patent number: 4514413
    Abstract: N-substituted imidazole derivatives of the formula I ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are identical or different and are each hydrogen or alkyl with 1 or 3 carbon atoms and Alk is an alkylene chain of 2 to 4 carbon atoms, and their salts with physiologically tolerated acids, processes for their preparation, drugs containing a compound of the formula I or one of its salts, and their use for treating disorders associated with gastric hyperacidity.
    Type: Grant
    Filed: April 7, 1983
    Date of Patent: April 30, 1985
    Assignee: BASF Aktiengesellschaft
    Inventors: Bernd Ostersehlt, Albrecht Franke, Fritz-Frieder Frickel, Marco Thyes, Ludwig Friedrich, Josef Gries, Dieter Lenke
  • Patent number: 4477451
    Abstract: 5,6-Dihydro-11-methylenemorphanthridin-6-ones of the formula I ##STR1## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the meanings given in the description, and their preparation and use.The novel substances are particularly useful for treating gastric and duodenal ulcers.
    Type: Grant
    Filed: April 5, 1983
    Date of Patent: October 16, 1984
    Assignee: BASF Aktiengesellschaft
    Inventors: Gerd Steiner, Ludwig Friedrich, Dieter Lenke
  • Patent number: 4474785
    Abstract: 2-Aryl-3,4-diazabicyclo[4.n.O]alk-2-en-5-ones of the formula I ##STR1## where m and n are identical or different and each is 1, 2 or 3, and R, R.sup.1 and R.sup.2 are identical or different and each is hydrogen or alkyl of 1 to 6 C atoms, said compounds are useful for treating high blood pressure and thrombo-embolic disorders.
    Type: Grant
    Filed: June 4, 1982
    Date of Patent: October 2, 1984
    Assignee: BASF Aktiengesellschaft
    Inventors: Phillip A. Rossy, Marco Thyes, Albrecht Franke, Horst Koenig, Josef Gries, Hans D. Lehmann, Dieter Lenke
  • Patent number: RE33476
    Abstract: Novel 6-(acylaminoaryl)-3(2H)-pyridazinones of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, A and B have the meanings given in the description, and their preparation are described.[.and inhibiting thrombocyte aggregation and gastric secretion.]..The compounds are useful for treating disorders .Iadd.and inhibiting thrombocyte aggregation and gastric secretion.Iaddend..
    Type: Grant
    Filed: May 2, 1988
    Date of Patent: December 4, 1990
    Assignee: BASF Akteingesellschaft
    Inventors: Phillip A. Rossy, Marco Thyes, Albrecht Franke, Horst Koenig, Hans D. Lehmann, Josef Gries, Ludwig Friedrich, Dieter Lenke