Patents by Inventor Dieter Voegelin

Dieter Voegelin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9778277
    Abstract: An apparatus (2) for the automatic testing of substances for carcinogenicity comprises: a plate support (3) on which at least one micro-well plate (1) can be placed; a movable pipetting unit (4) comprising a predetermined number of pipettes (40); a number of containers (5) containing a liquid culture medium (50), the number of containers (5) corresponding to the number of pipettes (40) of the pipetting unit (4); a dish support (6) on which a corresponding number of dishes (60) can be placed, each having a bottom and an upstanding side wall (601); a plurality of spinners (63) for spinning the dishes (60); a plurality of suction cups (62) for placing a lid (600) on each of the dishes; and a plurality of laterally arranged belts (64,65) for transporting the closed dishes (60) to an intermediate storage (8).
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: October 3, 2017
    Assignee: F. Hoffmann-La Roche AG
    Inventors: Dieter Voegelin, Patrick Iaiza, Thomas Zumstein, Tom Kissling
  • Patent number: 9267933
    Abstract: A hanging droplet plate (1) comprises a predetermined number of droplet compartments (10) each being capable of receiving a droplet of a liquid. The respective droplet compartment (10) comprises a circumferential microfluidic wetting barrier (102) which is arranged to surround a respective cavity (100) and which prevents a droplet from spreading beyond the microfluidic wetting barrier (102). The respective compartment (10) comprises a closed bottom (101) and at least one additional circumferential microfluidic wetting barrier (104), each additional circumferential microfluidic wetting barrier (104) which is arranged to surround a preceding circumferential microfluidic wetting barrier (102). A wettable area (103) is arranged between two adjacently arranged microfluidic wetting barriers (102, 104).
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: February 23, 2016
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Christof Fattinger, Patrick Iaiza, Tom Kissling, Dieter Voegelin, Thomas Zumstein, Claudia Mcginnis
  • Patent number: 9201084
    Abstract: A robotic microplate storage system includes a freezer room having freezing units and a first robot for moving and removing microplates into and out of the freezing unit. The first robot can also transfer microplates to a processing station, where the microplates are stored in a microplate recipient within the freezing unit. The storage system may also include at least one processing room which is thermally separated from the freezer room. Each processing room may include a processing station having a tube transfer module and a second robot for moving the microplates between the microplate recipients and the tube transfer module. The first robot may be designed such that it is only capable of removing a microplate recipient from and moving it into a freezing unit as well as transferring it from a freezing unit to a processing station or vice versa.
    Type: Grant
    Filed: September 30, 2009
    Date of Patent: December 1, 2015
    Assignee: F. HOFFMAN-LA ROCHE AG
    Inventors: Christof Fattinger, Remo Anton Hochstrasser, Dieter Voegelin, Thomas Zumstein
  • Publication number: 20140106395
    Abstract: A hanging droplet plate (1) comprises a predetermined number of droplet compartments (10) each being capable of receiving a droplet of a liquid. The respective droplet compartment (10) comprises a circumferential microfluidic wetting barrier (102) which is arranged to surround a respective cavity (100) and which prevents a droplet from spreading beyond the microfluidic wetting barrier (102). The respective compartment (10) comprises a closed bottom (101) and at least one additional circumferential microfluidic wetting barrier (104), each additional circumferential microfluidic wetting barrier (104) which is arranged to surround a preceding circumferential microfluidic wetting barrier (102). A wettable area (103) is arranged between two adjacently arranged microfluidic wetting barriers (102, 104).
    Type: Application
    Filed: March 2, 2012
    Publication date: April 17, 2014
    Inventors: Christof Fattinger, Patrick Iaiza, Tom Kissling, Dieter Voegelin, Thomas Zumstein, Claudia Mcginnis
  • Publication number: 20120276575
    Abstract: A unit (10) for the preparation of cells contained in a liquid comprises a storage chamber (20) configured to store the liquid containing the cells and to release the stored liquid via an exit opening (22) upon the application of a predetermined external force, in particular a centrifugal force. A passage (30) adjacently arranged to the exit opening (22) has a cross-section larger than that of the exit opening (22). The wall at the transition from the exit opening (22) to the passage (30) forms an edge (32). The unit further comprises an observation member (50) for receiving the released liquid and an absorbing means (40) arranged adjacent to the observation member (50) between the passage (30) and the observation member (50). The absorbing means (40) has an aperture (42) allowing the released liquid to travel onto the observation member (50), and removes the liquid so as to leave the cells on the observation member (50) for observation.
    Type: Application
    Filed: December 20, 2010
    Publication date: November 1, 2012
    Inventors: Christof Fattinger, Rene Rietmann, Dieter Voegelin
  • Publication number: 20120149058
    Abstract: An apparatus (2) for the automatic testing of substances for carcinogenicity comprises: a plate support (3) on which at least one micro-well plate (1) can be placed; a movable pipetting unit (4) comprising a predetermined number of pipettes (40); a number of containers (5) containing a liquid culture medium (50), the number of containers (5) corresponding to the number of pipettes (40) of the pipetting unit (4); a dish support (6) on which a corresponding number of dishes (60) can be placed, each having a bottom and an upstanding side wall (601); spinning means (63) for spinning the dishes (60); closing means (62) for placing a lid (600) on each of the dishes; transport means (64,65) for transporting the closed dishes (60) to an intermediate storage (8).
    Type: Application
    Filed: March 19, 2010
    Publication date: June 14, 2012
    Inventor: Dieter Voegelin
  • Patent number: 7867452
    Abstract: A multi-well filtration device for filtering a suspension comprises a filtration plate with a filtration chamber and a collecting plate with a collecting well. The filtration chamber is connected to the collecting well and a filter element is arranged between the filtration chamber and the collecting well. A separation layer is arranged between the filtration plate and the collecting plate adjacent to the filter element. The use such of a separation layer allows an easy detachment of the filtration plate from the collecting plate. The detached filtration plate can comfortably be transferred into an analysis device, in which the solid phase of the filtration chamber can separately be analyzed through the separation layer, without any replacement of the solid phase.
    Type: Grant
    Filed: May 9, 2007
    Date of Patent: January 11, 2011
    Assignee: F. Hoffmann-La Roche AG
    Inventors: Remo Anton Hochstrasser, Dieter Voegelin, Urs Schwitter, Pirmin Hidber
  • Patent number: 7857575
    Abstract: A stacker (1) for storing a plurality of microplates each having a top surface side and a bottom surface side opposed to the top surface side, comprises a housing and a removal gate (13) for removing a microplate of the plurality of microplates out of the housing. The stacker (1) is arranged to accommodate the plurality of microplates inside the housing such that the top surface side of one microplate of the plurality of microplates abuts on the bottom surface side of an adjacent microplate of the plurality of microplates and such that the housing adjoins to the plurality of microplates. Using such a stacker 1, the plurality of microplates can be arranged and stored in a compact manner wherein the single microplates of the plurality of microplates can still selectively and efficiently be accessed.
    Type: Grant
    Filed: March 27, 2008
    Date of Patent: December 28, 2010
    Assignee: F. Hoffmann-LaRoche AG
    Inventors: Christoph Fattinger, Thomas Zumstein, Remo Anton Hochstrasser, Dieter Voegelin
  • Patent number: 7794668
    Abstract: A reaction vessel for use in an apparatus for parallel synthetic chemistry with a reaction chamber space for containing contents of a chemical reaction and a discharge channel for selectively removing liquid contents of the reaction chamber. The invention includes an apparatus for receiving a plurality of the reaction vessels, a method for using the apparatus and a method for forming the vessels.
    Type: Grant
    Filed: July 21, 2006
    Date of Patent: September 14, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Roman Bar, Claus Mueller, Dieter Voegelin
  • Publication number: 20100086440
    Abstract: In some embodiments of the present disclosure, a robotic storage system for storing microplates carrying a plurality of sample tubes is provided and may comprise a freezer room having a plurality of freezing units and a first robot being capable of removing a microplate from and moving a microplate into a freezing unit. The first robot may be further capable of transferring the microplate to a processing station, where the microplates are stored in the freezing units such that a plurality of microplates are arranged one above the other in a microplate recipient. The robotic storage system may also include at least one processing room and means for thermally separating the processing room from the freezer room. Each processing room may include a processing station having at least one tube transfer module as well as a second robot for moving the microplates between the microplate recipients and the at least one tube transfer module.
    Type: Application
    Filed: September 30, 2009
    Publication date: April 8, 2010
    Applicant: F. Hoffmann-La Roche AG
    Inventors: Christof Fattinger, Remo Anton Hochstrasser, Dieter Voegelin, Thomas Zumstein
  • Publication number: 20100068100
    Abstract: Some embodiments of the present disclosure include a sample carrier for biologically active samples, in particular for toxic samples and especially for highly toxic samples. Such embodiments include a bottom part, a first membrane, a spacer, a second membrane and a lid. The bottom part and the lid may be connectable such that the first membrane, the spacer and the second membrane are enclosed between the bottom part and the lid. The bottom part and the lid may include means for a non-detachable form-locking connection between the bottom part and the lid.
    Type: Application
    Filed: August 20, 2009
    Publication date: March 18, 2010
    Applicant: F. Hoffmann-La Roche AG
    Inventors: Dieter Voegelin, Olaf Grassmann
  • Publication number: 20100031685
    Abstract: Embodiments of the present invention include a convection barrier for a freezer which may comprise a plurality of individual flaps arranged one above the other in a manner such as to be capable of forming a closed curtain of individual flaps, with each individual flap extending over a predetermined width corresponding at least to the width of the interior of the freezer and being pivotable between a closed position and an open position so as to allow access to the interior of the freezer when the flap is in the open position. Embodiments may also include actuation means attached to the individual flaps for allowing an actuator to engage the actuation means of an individual flap so as to pivot the said flap between the closed position and the open position.
    Type: Application
    Filed: July 31, 2009
    Publication date: February 11, 2010
    Applicant: F. Hoffmann-La Roche AG
    Inventors: Thomas Zumstein, Christof Fattinger, Dieter Voegelin
  • Publication number: 20080260511
    Abstract: A stacker (1) for storing a plurality of microplates each having a top surface side and a bottom surface side opposed to the top surface side, comprises a housing and a removal gate (13) for removing a microplate of the plurality of microplates out of the housing. The stacker (1) is arranged to accommodate the plurality of microplates inside the housing such that the top surface side of one microplate of the plurality of microplates abuts on the bottom surface side of an adjacent microplate of the plurality of microplates and such that the housing adjoins to the plurality of microplates. Using such a stacker 1, the plurality of microplates can be arranged and stored in a compact manner wherein the single microplates of the plurality of microplates can still selectively and efficiently be accessed.
    Type: Application
    Filed: March 27, 2008
    Publication date: October 23, 2008
    Applicant: F. Hoffmann-La Roche AG
    Inventors: Christoph Fattinger, Thomas Zumstein, Remo Anton Hochstrasser, Dieter Voegelin
  • Patent number: 7438861
    Abstract: A heatable pipette, with a needle has an inner channel defined by an inner wall, arranged to conduct electric current through the inner wall for resistively heating the inner wall. The needle has an outer wall, which is defined between the outer wall and the inner wall and connectable for providing pressure air into the outer channel. By conducting current directly through the inner wall, the inner wall itself operates as resistor. Particularly, if the inner wall is made of an appropriate material, for example of stainless steel, the ohmic resistance of the inner wall is not negligible even if the inner wall is very thin. Therefore, the inner wall can directly be used as resistor for resistance heating of the inner wall even if the needle is manufactured in small dimensions.
    Type: Grant
    Filed: May 16, 2007
    Date of Patent: October 21, 2008
    Assignee: F. Hoffmann-La Roche AG
    Inventors: Remo Anton Hochstrasser, Dieter Voegelin, Frédéric Ran
  • Publication number: 20070297950
    Abstract: An equilibration device for equilibrating a comparably economic equilibration of a fluid. A first sealing layer is adjacent to the surface side between the plate and the cover. A second sealing layer is arrangeable adjacent to the cover between the plate and the cover and a tube with an open end, which is inside the well such that the open end of the tube projects above the opening of the well. The use of two sealing layers in the equilibration device allows combining the advantages of a material of the first sealing layer, e.g. high flexibility to seal uneven areas and to compensate the step formed by the tube projecting above the opening of the well, as well as the advantages of the second sealing layer, e.g. inexpensiveness, can come to combined effect when the two sealing layers are arranged appropriately.
    Type: Application
    Filed: June 14, 2007
    Publication date: December 27, 2007
    Applicant: F. Hoffmann-La Roche AG
    Inventors: Remo Anton Hochstrasser, Dieter Voegelin, Urs Schwitter, Pirmin Hidber
  • Publication number: 20070274870
    Abstract: A heatable pipette, with a needle has an inner channel defined by an inner wall, arranged to conduct electric current through the inner wall for resistively heating the inner wall. The needle has an outer wall, which is defined between the outer wall and the inner wall and connectable for providing pressure air into the outer channel. By conducting current directly through the inner wall, the inner wall itself operates as resistor. Particularly, if the inner wall is made of an appropriate material, for example of stainless steel, the ohmic resistance of the inner wall is not negligible even if the inner wall is very thin. Therefore, the inner wall can directly be used as resistor for resistance heating of the inner wall even if the needle is manufactured in small dimensions.
    Type: Application
    Filed: May 16, 2007
    Publication date: November 29, 2007
    Applicant: F. Hoffmann-La Roche AG
    Inventors: Remo Anton Hochstrasser, Dieter Voegelin, Frederic Ran
  • Publication number: 20070264164
    Abstract: A Multi-well plate for mixing a fluid, comprises a plurality of wells. Each of the wells has an opening arranged at a top side of the multi-well plate. At least one of the wells has a cross-section parallel to the top side having an elongated shape. The multi-well plate comprises 384 wells arranged in 16 rows and 24 columns or 96 wells arranged in 8 rows and 12 columns. By means of such a multi-well plate a faster and therefore more efficient mixing is possible using standard mixing devices such as shakers.
    Type: Application
    Filed: May 9, 2007
    Publication date: November 15, 2007
    Applicant: F. Hoffmann-La Roche AG
    Inventors: Remo Anton Hochstrasser, Dieter Voegelin
  • Publication number: 20070264163
    Abstract: A multi-well filtration device for filtering a suspension comprises a filtration plate with a filtration chamber and a collecting plate with a collecting well. The filtration chamber is connected to the collecting well and a filter element is arranged between the filtration chamber and the collecting well. A separation layer is arranged between the filtration plate and the collecting plate adjacent to the filter element. The use such of a separation layer allows an easy detachment of the filtration plate from the collecting plate. The detached filtration plate can comfortably be transferred into an analysis device, in which the solid phase of the filtration chamber can separately be analyzed through the separation layer, without any replacement of the solid phase.
    Type: Application
    Filed: May 9, 2007
    Publication date: November 15, 2007
    Applicant: F. Hoffmann-La Roche AG
    Inventors: Remo Anton Hochstrasser, Dieter Voegelin, Urs Schwitter, Pirmin Hidber
  • Publication number: 20060263273
    Abstract: A reaction vessel for use in an apparatus for parallel synthetic chemistry with a reaction chamber space for containing contents of a chemical reaction and a discharge channel for selectively removing liquid contents of the reaction chamber. The invention includes an apparatus for receiving a plurality of the reaction vessels, a method for using the apparatus and a method for forming the vessels.
    Type: Application
    Filed: July 21, 2006
    Publication date: November 23, 2006
    Inventors: Dieter Voegelin, Roman Bar, Claus Muller
  • Publication number: 20050136546
    Abstract: A microtiter plate for processing samples, having a liquid component or a liquid and a solid component or a liquid and a gel component, comprising: a single piece body which has an array of cavities, each cavity having an open upper end, a closed bottom end, and a bottom inner surface and comprises a first chamber for receiving a predetermined volume of a sample to be processed, a second chamber and a passage which fluidically connects the first and second chambers with each other, and a region in the lower part of passage adjacent to the bottom end of the cavity, the region so configured and dimensioned that it allows passage of liquid from one of said chambers to the other only when a centrifugal force is applied to the microtiter plate, but does not allow passage of any solid or gel component the size of which is larger than the width of the region.
    Type: Application
    Filed: December 13, 2004
    Publication date: June 23, 2005
    Inventors: Peter Berndt, Gregor Dernick, Christof Fattinger, Remo Hochstrasser, Dieter Voegelin