Patents by Inventor Dietrich Stuber

Dietrich Stuber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing hydrophobic polypeptides and proteins, and fusion proteins for use in producing same
    Patent number: 5750374
    Abstract: Methods are disclosed for the production and purification of hydrophobic fusion proteins production and purification of said hydrophobic polypeptides, proteins or peptides. Homogeneous monomeric .beta.-amyloid peptide and tests for screening amyloid toxicity-inhibiting drugs using this monomeric .beta.-amyloid peptide relate to these fusion proteins.
    Type: Grant
    Filed: June 29, 1994
    Date of Patent: May 12, 1998
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Heinz Dobeli, Nicholas Draeger, Gerda Huber Trottman, Peter Jakob, Dietrich Stuber
  • Tumor necrosis factor muteins
    Patent number: 5597899
    Abstract: Human TNF muteins having higher binding affinity for human p75-TNF receptor than for human p55-TNF receptor include muteins having at least one different amino acid relative to wild-type human TNF at a position corresponding to position 33, 65, 67, 75, 87, 143, 145 or 147 of the wild-type amino acid sequence.
    Type: Grant
    Filed: March 24, 1994
    Date of Patent: January 28, 1997
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David Banner, Werner Lesslauer, Hansruedi Lotscher, Dietrich Stuber
  • TNF-muteins
    Patent number: 5486463
    Abstract: The present invention is directed to a human Tumor Necrosis Factor mutein or a pharmaceutically acceptable salt thereof having selective binding affinity for the human p55-Tumor-Necrosis-Factor-Receptor characterized in that the amino acid sequence of human Tumor Necrosis Factor is changed at least at position 86 having a threonine instead of a serine residue, a DNA sequence coding for such a mutein, a vector comprising such a DNA sequence, and a host cell transformed by such a vector.
    Type: Grant
    Filed: April 1, 1993
    Date of Patent: January 23, 1996
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Werner Lesslauer, Hansruedi Lotscher, Dietrich Stuber
  • Affinity peptides
    Patent number: 5310663
    Abstract: Fusion proteins and a process for their purification by means of metal chelate affinity chromatography on NTA resins are provided by this invention.
    Type: Grant
    Filed: June 18, 1993
    Date of Patent: May 10, 1994
    Assignee: Hoffman-La Roche Inc.
    Inventors: Heinz Dobeli, Bernhard Eggimann, Reiner Gentz, Erich Hochuli, Dietrich Stuber
  • Affinity peptides
    Patent number: 5284933
    Abstract: Fusion proteins and a process for their purification by means of metal chelate affinity chromatography on NTA resins are provided by this invention.
    Type: Grant
    Filed: February 22, 1988
    Date of Patent: February 8, 1994
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Heinz Dobeli, Bernhard Eggimann, Reiner Gentz, Erich Hochuli, Dietrich Stuber