Patents by Inventor Dimitar Filipov

Dimitar Filipov has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for preparing a pan-JAK inhibitor and related intermediate compounds
    Patent number: 11739103
    Abstract: The present disclosure provides processes for preparing a crystalline form of 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile and related intermediate compounds.
    Type: Grant
    Filed: October 7, 2021
    Date of Patent: August 29, 2023
    Assignee: Theravance Biopharma R&D LP, LLC
    Inventors: Norbert Kraut, Matteo Conza, Anja Huste, Vit Lellek, Bjorn Gielen, Christian Pater, Dimitar Filipov, Xiaojun Huang, Stephen Roseblade
  • PROCESSES FOR PREPARING A PAN-JAK INHIBITOR AND RELATED INTERMEDIATE COMPOUNDS
    Publication number: 20220112219
    Abstract: The present disclosure provides processes for preparing a crystalline form of 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile and related intermediate compounds.
    Type: Application
    Filed: October 7, 2021
    Publication date: April 14, 2022
    Inventors: Norbert Kraut, Matteo Conza, Anja Huste, Vit Lellek, Bjorn Gielen, Christian Pater, Dimitar Filipov, Xiaojun Huang, Stephen Roseblade
  • Process for preparing 2-(1-(tert-butoxycarbonyl)piperidine-4-yl)benzoic acid
    Patent number: 10640467
    Abstract: The invention relates to processes for preparing 2-(1-(tert-butoxycarbonyl)-piperidine-4-yl)benzoic acid having formula I: Among its various uses, this compound is useful as an intermediate for preparing ampreloxetine and salts thereof.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: May 5, 2020
    Assignee: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventors: Miroslav Rapta, Dimitar Filipov
  • PROCESS FOR PREPARING 2-(1-(tert-BUTOXYCARBONYL)PIPERIDINE-4-YL)BENZOIC ACID
    Publication number: 20190367455
    Abstract: The invention relates to processes for preparing 2-(1-(tert-butoxycarbonyl)-piperidine-4-yl)benzoic acid having formula I: Among its various uses, this compound is useful as an intermediate for preparing ampreloxetine and salts thereof.
    Type: Application
    Filed: May 29, 2019
    Publication date: December 5, 2019
    Applicant: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventors: Miroslav Rapta, Dimitar Filipov
  • Hydrochloride salts of a glycopeptide-cephalosporin antbiotic compond
    Patent number: 9161990
    Abstract: The present invention relates to a compound of formula I: wherein x is in the range of from about 1 to about 2. The invention also relates to pharmaceutical compositions containing such compounds; processes for preparing such compounds; and methods of using such compounds to, for example, treat a bacterial infection.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: October 20, 2015
    Assignee: Theravance Biopharma Antibiotics IP, LLC
    Inventors: Weijiang Zhang, Ronnie Cheung, Dimitar Filipov, Jack Green, Junning Lee
  • HYDROCHLORIDE SALTS OF AN ANTIBIOTIC COMPOUND
    Publication number: 20140274877
    Abstract: The present invention relates to a compound of formula I: wherein x is in the range of from about 1 to about 2. The invention also relates to pharmaceutical compositions containing such compounds; processes for preparing such compounds; and methods of using such compounds to, for example, treat a bacterial infection.
    Type: Application
    Filed: March 6, 2014
    Publication date: September 18, 2014
    Applicant: THERAVANCE, INC.
    Inventors: Weijiang Zhang, Ronnie Cheung, Dimitar Filipov, Jack Green, Junning Lee
  • XINAFOATE SALT OF A SUBSTITUTED 5-OXAZOL-2-YL-QUINOLINE COMPOUND
    Publication number: 20080027101
    Abstract: The present invention relates to the compound of the formula To methods of treating upper and lower obstructive airway diseases using said compound, to formulations comprising it, and to polymorphs and processes of synthesis of the polymorphic forms.
    Type: Application
    Filed: July 10, 2007
    Publication date: January 31, 2008
    Inventors: Pauline Ting, Joe Lee, Kung-I Feng, Michael Reeder, Scott Trzaska, Man Zhu, Chen Mao, Dimitar Filipov, Dimitrios Zarkadas