Patents by Inventor Dinesh J. Dagli

Dinesh J. Dagli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HYPOXIA-TARGETED POLYMERIC MICELLES FOR CANCER THERAPY AND IMAGING
    Publication number: 20190125670
    Abstract: The present invention provides a composition and method for targeting hypoxic tumor areas for detection or treatment or a treatment adjuvant for cancer. Specifically, a hypoxia targeting moiety is conjugated to a polymeric micelle containing imaging agents, therapeutic agents, or therapeutic adjuvants.
    Type: Application
    Filed: May 3, 2018
    Publication date: May 2, 2019
    Inventors: Brij P. Giri, Kristina Gregg, Pritam Singh, Dinesh J. Dagli, Anshu Giri
  • HYPOXIA-TARGETED POLYMERIC MICELLES FOR CANCER THERAPY AND IMAGING
    Publication number: 20180344639
    Abstract: The present invention provides a composition and method for targeting hypoxic tumor areas for detection or treatment or a treatment adjuvant for cancer. Specifically, a hypoxia targeting moiety is conjugated to a polymeric micelle containing imaging agents, therapeutic agents, or therapeutic adjuvants.
    Type: Application
    Filed: February 20, 2018
    Publication date: December 6, 2018
    Inventors: Brij P. Giri, Kristina Gregg, Pritam Singh, Dinesh J. Dagli, Anshu Giri
  • Ultra-sensitive chemiluminescent substrates for enzymes and their conjugates
    Patent number: 9533974
    Abstract: New chemiluminescent compounds, stable in aqueous buffers, for use in biological assaying include acridane-based compounds and 1,2-dioxetanes. Among the new acridane-based compounds are water-soluble acridanes, enhancer coupled acridanes, bis and tris-acridanes as well as acridane-1,2-dioxetanes. Among the new 1,2-dioxetanes are electron deficient group-containing dioxetanes and tethered bis-1,2-dioxetanes. The 1,2-dioxetanes are useful as substrates for various enzymes. The acridanes can be admixed with an oxidizing agent, an aqueous buffer and, optionally, a stabilizer to form a substrate or reagent formulation useful for assaying, inter alia, HRP.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: January 3, 2017
    Assignee: Michigan Diagnostics, LLC
    Inventors: Brij Pal Giri, Dinesh J. Dagli, Pritam Singh
  • ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES
    Publication number: 20150031889
    Abstract: New chemiluminescent compounds, stable in aqueous buffers, for use in biological assaying include acridane-based compounds and 1,2-dioxetanes. Among the new acridane-based compounds are water-soluble acridanes, enhancer coupled acridanes, bis and tris-acridanes as well as acridane-1,2-dioxetanes. Among the new 1,2-dioxetanes are electron deficient group-containing dioxetanes and tethered bis-1,2-dioxetanes. The 1,2-dioxetanes are useful as substrates for various enzymes. The acridanes can be admixed with an oxidizing agent, an aqueous buffer and, optionally, a stabilizer to form a substrate or reagent formulation useful for assaying, inter alia, HRP.
    Type: Application
    Filed: August 14, 2014
    Publication date: January 29, 2015
    Inventors: Brij Pal Giri, Dinesh J. Dagli, Pritam Singh
  • Hypoxia-Targeted Polymeric Micelles For Cancer Therapy And Imaging
    Publication number: 20140010760
    Abstract: The present invention provides a composition and method for targeting hypoxic tumor areas for detection or treatment or a treatment adjuvant for cancer. Specifically, a hypoxia targeting moiety is conjugated to a polymeric micelle containing imaging agents, therapeutic agents, or therapeutic adjuvants.
    Type: Application
    Filed: March 14, 2013
    Publication date: January 9, 2014
    Inventors: Brij P. Giri, Kristina Gregg, Pritam Singh, Dinesh J. Dagli, Anshu Giri