Patents by Inventor Dirk Hubert SIEPE

Dirk Hubert SIEPE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RECEPTOR ELIMINATION BY UBIQUITIN LIGASE RECRUITMENT
    Publication number: 20240239891
    Abstract: Provided herein are Receptor Elimination by E3 Ubiquitin Ligase Recruitment (REULR) constructs and related compositions, kits, methods of use and methods of production. REULR constructs comprise a variable domain heavy chain antibody (VHH) specific for a E3 Ubiquitin Ligase, and a VHH specific for a target protein, where in the E3 Ubiquitin Ligase and the target protein are different. REULR constructs described here target proteins associated with many maladies, but especially cancer.
    Type: Application
    Filed: May 19, 2022
    Publication date: July 18, 2024
    Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Kenan Christopher GARCIA, Dirk Hubert SIEPE