Patents by Inventor Dmitry Koltun

Dmitry Koltun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-HYDROQUINAZOLIN-4-ONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS
    Publication number: 20090105283
    Abstract: The present invention discloses 3-hydroquinazolin-4-one derivatives for use as inhibitors of stearoyl-CoA desaturase. The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cancer, cardiovascular disease, diabetes, obesity, metabolic syndrome and the like.
    Type: Application
    Filed: October 15, 2008
    Publication date: April 23, 2009
    Inventors: Dmitry Koltun, Eric Parkhill, Melanie Boze, Jeff Zablocki, Natalya Vasilevich, Elena Mayboroda, Andrei Glushkov, Andrew G. Cole, Jeffrey Chisholm
  • ABCA1 ELEVATING COMPOUNDS
    Publication number: 20080293757
    Abstract: The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.
    Type: Application
    Filed: August 6, 2008
    Publication date: November 27, 2008
    Inventors: Matthew Abelman, Robert Jiang, Jeff Zablocki, Dmitry Koltun
  • 3-HYDROQUINAZOLIN-4-ONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS
    Publication number: 20080255161
    Abstract: The present invention discloses 3-hydroquinazolin-4-one derivatives for use as inhibitors of stearoyl-CoA desaturase. The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cancer, cardiovascular disease, diabetes, obesity, metabolic syndrome and the like.
    Type: Application
    Filed: April 9, 2008
    Publication date: October 16, 2008
    Inventors: Dmitry Koltun, Eric Parkhill, Melanie Boze, Jeff Zablocki, Natalya Vasilevich, Elena Mayboroda, Andrei Glushkov, Andrew Cole, Jeffrey Chisholm
  • Bicyclic Nitrogen-containing Heterocyclic compounds for use as Stearoyl CoA Desaturase inhibitors
    Publication number: 20080255130
    Abstract: The present invention discloses bicyclic nitrogen-containing heterocyclic compounds for use as inhibitors of stearoyl-CoA desaturase. The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cardiovascular disease, diabetes, obesity, oily skin conditions, metabolic syndrome, and the like.
    Type: Application
    Filed: April 9, 2008
    Publication date: October 16, 2008
    Inventors: Dmitry Koltun, Jeff Zablocki, Eric Parkhill, Andrei Glushkov, Natalya Vasilevich, Timur Zilbershtein, Alexey Ivanov, Jeffrey Chisholm
  • PTERIDINONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS
    Publication number: 20080249100
    Abstract: The present invention discloses pteridinone derivatives for use as inhibitors of stearoyl-CoA desaturase having the structure of Formula I: The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cardiovascular disease, diabetes, obesity, metabolic syndrome and the like.
    Type: Application
    Filed: October 5, 2007
    Publication date: October 9, 2008
    Inventors: Jeffrey Chisholm, Dmitry Koltun, Jeff Zablocki, Eric Parkhill, Andrey Glushkov, Natalya Vasilevich, Timur Zilbershtein, Andrew Cole, Tsung Lin, Ian Henderson
  • ABCA1 elevating compounds
    Patent number: 7432276
    Abstract: The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.
    Type: Grant
    Filed: December 27, 2006
    Date of Patent: October 7, 2008
    Assignee: CV Therapeutics, Inc.
    Inventors: Matthew Abelman, Robert Jiang, Jeff Zablocki, Dmitry Koltun, Melanie Boze
  • ABCA1 elevating compounds
    Patent number: 7423045
    Abstract: The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.
    Type: Grant
    Filed: June 28, 2006
    Date of Patent: September 9, 2008
    Assignee: CV Therapeutics, Inc.
    Inventors: Matthew Abelman, Robert Jiang, Jeff Zablocki, Dmitry Koltun
  • Substituted heterocyclic compounds
    Patent number: 7407960
    Abstract: Disclosed are novel heterocyclic compounds having the structure which are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.
    Type: Grant
    Filed: September 7, 2006
    Date of Patent: August 5, 2008
    Assignee: CV Therapeutics, Inc.
    Inventors: Elfatih Elzein, Dmitry Koltun, Jeff Zablocki
  • BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS FOR USE AS STEAROYL CoA DESATURASE INHIBITORS
    Publication number: 20080139570
    Abstract: The present invention discloses bicyclic nitrogen-containing heterocyclic compounds for use as inhibitors of stearoyl-CoA desaturase. The compounds are useful in treating and/or preventing various human diseases, mediated by stearoyl-CoA desaturase (SCD) enzymes, especially diseases related to abnormal lipid levels, cardiovascular disease, diabetes, obesity, oily skin conditions, metabolic syndrome, and the like.
    Type: Application
    Filed: October 5, 2007
    Publication date: June 12, 2008
    Inventors: Jeffrey Chisholm, Dmitry Koltun, Jeff Zablocki, Eric Parkhill, Andrey Glushkov, Natalya Vasilevich, Timur Zilbershtein, Alexey Ivanov
  • Substituted Heterocyclic Compounds
    Publication number: 20080070927
    Abstract: Disclosed are novel piperazine and piperazine derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, diabetes, intermitten claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction.
    Type: Application
    Filed: September 17, 2007
    Publication date: March 20, 2008
    Inventors: Jeff Zablocki, Dmitry Koltun
  • Substituted heterocyclic compounds
    Patent number: 7271169
    Abstract: Disclosed are novel heterocyclic compounds having the structure which are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.
    Type: Grant
    Filed: September 7, 2005
    Date of Patent: September 18, 2007
    Assignee: CV Therapeutics, Inc.
    Inventors: Jeff Zablocki, Dmitry Koltun
  • ABCA1 elevating compounds
    Publication number: 20070203245
    Abstract: The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.
    Type: Application
    Filed: December 7, 2006
    Publication date: August 30, 2007
    Inventors: Dmitry Koltun, Melanie Boze, Jeff Zablocki
  • ABCA1 elevating compounds
    Publication number: 20070191379
    Abstract: The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.
    Type: Application
    Filed: December 27, 2006
    Publication date: August 16, 2007
    Inventors: Matthew Abelman, Robert Jiang, Jeff Zablocki, Dmitry Koltun, Melanie Boze
  • ABCA1 elevating compounds
    Publication number: 20070010544
    Abstract: The present invention provides compounds useful for increasing cellular ATP binding cassette transporter ABCA1 production in mammals, and to methods of using such compounds in the treatment of coronary artery diseases, dyslipidiemias and metabolic syndrome. The invention also relates to methods for the preparation of such compounds, and to pharmaceutical compositions containing them.
    Type: Application
    Filed: June 28, 2006
    Publication date: January 11, 2007
    Inventors: Matthew Abelman, Robert Jiang, Jeff Zablocki, Dmitry Koltun
  • Substituted heterocyclic compounds
    Publication number: 20070004751
    Abstract: Disclosed are novel heterocyclic compounds having the structure which are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.
    Type: Application
    Filed: September 7, 2006
    Publication date: January 4, 2007
    Inventors: Elfatih Elzein, Dmitry Koltun, Jeff Zablocki
  • Prodrugs of A2B adenosine receptor antagonists
    Publication number: 20060293283
    Abstract: Disclosed are prodrugs of A2B adenosine receptor antagonists, and their use in treating mammals for various disease states.
    Type: Application
    Filed: June 14, 2006
    Publication date: December 28, 2006
    Inventors: Rao Kalla, Dmitry Koltun, Jeff Zablocki, Elfatih Elzein
  • Substituted heterocyclic compounds
    Patent number: 7125876
    Abstract: Disclosed are novel heterocyclic compounds having the structure which are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useflul in the treatment of diabetes.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: October 24, 2006
    Assignee: CV Therapeutics, Inc.
    Inventors: Elfatih Elzein, Dmitry Koltun, Jeff Zablocki
  • Substituted heterocyclic compounds
    Publication number: 20060052605
    Abstract: Disclosed are novel piperazine derivatives, useful for the treatment of various disease states, in particular diseases such as atrial and ventricular arrhythmias, diabetes, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction.
    Type: Application
    Filed: September 7, 2005
    Publication date: March 9, 2006
    Inventors: Jeff Zablocki, Dmitry Koltun
  • ABCA-1 elevating compounds
    Patent number: 6900219
    Abstract: The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery disease.
    Type: Grant
    Filed: April 4, 2003
    Date of Patent: May 31, 2005
    Assignee: CV Therapeutics, Inc.
    Inventors: Prabha Ibrahim, Michael Campbell, Robert Jiang, Christopher Morrison, Kevin Shenk, William Shirley, Jeff Zablocki, Dmitry Koltun, Reina Natero
  • Substituted heterocyclic compounds
    Publication number: 20040152890
    Abstract: Disclosed are novel heterocyclic derivatives, useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes.
    Type: Application
    Filed: December 5, 2003
    Publication date: August 5, 2004
    Inventors: Elfatih Elzein, Dmitry Koltun, Jeff Zablocki