Patents by Inventor Domenica TORINO

Domenica TORINO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic CX3CR1 receptor agonists
    Patent number: 11958839
    Abstract: Disclosed herein are novel cycloalka[b]heteroaryl compounds having CX3CR1/fractalkine receptor (CX3CR1) agonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with CX3CR1 receptor activity in animals, in particular humans.
    Type: Grant
    Filed: September 22, 2021
    Date of Patent: April 16, 2024
    Assignees: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, GOLGI NEUROSCIENCES, S.R.L.
    Inventors: Paolo Pevarello, William J. Ray, Mary Hamby, Yaima Luzardo Lightfoot, Philip Jones, Russell Thomas, Chiara Liberati, Domenica Torino, Valentina Cusano, Francesco Piscitelli, Ali Munaim Yousif, Silvia Bovolenta
  • Heterocyclic Derivatives as P2X7 Receptor Antagonists
    Publication number: 20240034737
    Abstract: The present invention relates to novel 1,4-substituted piperidine compounds of formula (I) having P2X7 receptor (P2X7) antagonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans.
    Type: Application
    Filed: December 16, 2021
    Publication date: February 1, 2024
    Applicant: BREYE THERAPEUTICS APS
    Inventors: Paolo PEVARELLO, Mariangela SODANO, Valentina CUSANO, Francesco PISCITELLI, Domenica TORINO, Rocco VITALONE, Ali Munaim YOUSIF, Oleksii ARTAMONOV
  • Substituted pyrazoles FFA4/GPR120 receptor agonists
    Patent number: 11597702
    Abstract: Disclosed are compounds of formula (I) or a pharmaceutically acceptable salt thereof: These compounds have FFA4/GPR120 receptor (FFA4) agonistic properties. Also disclosed are pharmaceutical compositions including these compounds, chemical processes for preparing them and their use in the treatment or prophylaxis of diseases associated with FFA4 receptor activity in animals, in particular humans.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: March 7, 2023
    Assignee: GOLGI NEUROSCIENCES S.R.L.
    Inventors: Domenica Torino, Francesco Piscitelli, Valentina Cusano, Rocco Vitalone, Andrew Griffin, Russell Thomas, Paolo Pevarello, Ali Munaim Yousif
  • HETEROCYCLIC TRPML1 AGONISTS
    Publication number: 20230010299
    Abstract: Disclosed is a compound of formula (I) or a stereoisomer thereof, or a salt of any of the foregoing and to processes for its preparation. The compounds of formula (I) are useful in the treatment TRPML1-mediated disorders or diseases.
    Type: Application
    Filed: November 12, 2020
    Publication date: January 12, 2023
    Inventors: Paolo PEVARELLO, Valentina CUSANO, Mariangela SODANO, Domenica TORINO, Rocco VITALONE, Chiara LIBERATI, Francesco PISCITELLI
  • BICYCLIC CX3CR1 RECEPTOR AGONISTS
    Publication number: 20220259191
    Abstract: Disclosed herein are novel cycloalka[b]heteroaryl compounds having CX3CR1/fractalkine receptor (CX3CR1) agonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with CX3CR1 receptor activity in animals, in particular humans.
    Type: Application
    Filed: September 22, 2021
    Publication date: August 18, 2022
    Inventors: Paolo PEVARELLO, William J. RAY, Mary HAMBY, Yaima Luzardo LIGHTFOOT, Philip JONES, Russell THOMAS, Chiara LIBERATI, Domenica TORINO, Valentina CUSANO, Francesco PISCITELLI, Ali Munaim YOUSIF, Silvia BOVOLENTA
  • Bicyclic CX3CR1 receptor agonists
    Patent number: 11155538
    Abstract: Disclosed herein are novel cycloalka[b]heteroaryl compounds having CX3CR1/fractalkine receptor (CX3CR1) agonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with CX3CR1 receptor activity in animals, in particular humans.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: October 26, 2021
    Assignees: Board of Regents, The University of Texas System, Axxam S.p.A.
    Inventors: Paolo Pevarello, William J. Ray, Mary Hamby, Yaima Luzardo Lightfoot, Philip Jones, Russell Thomas, Chiara Liberati, Domenica Torino, Valentina Cusano, Francesco Piscitelli, Ali Munaim Yousif, Silvia Bovolenta
  • SUBSTITUTED PYRAZOLES FFA4/GPR120 RECEPTOR AGONISTS
    Publication number: 20210087148
    Abstract: Disclosed are compounds of formula (I) or a pharmaceutically acceptable salt thereof: These compounds have FFA4/GPR120 receptor (FFA4) agonistic properties. Also disclosed are pharmaceutical compositions including these compounds, chemical processes for preparing them and their use in the treatment or prophylaxis of diseases associated with FFA4 receptor activity in animals, in particular humans.
    Type: Application
    Filed: March 12, 2019
    Publication date: March 25, 2021
    Inventors: Domenica TORINO, Francesco PISCITELLI, Valentina CUSANO, Rocco VITALONE, Andrew GRIFFIN, Russell THOMAS, Paolo PEVARELLO, Ali Munaim YOUSIF
  • BICYCLIC CX3CR1 RECEPTOR AGONISTS
    Publication number: 20210024510
    Abstract: Disclosed herein are novel cycloalka[b]heteroaryl compounds having CX3CR1/fractalkine receptor (CX3CR1) agonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with CX3CR1 receptor activity in animals, in particular humans.
    Type: Application
    Filed: July 23, 2020
    Publication date: January 28, 2021
    Inventors: Paolo PEVARELLO, William J. RAY, Mary HAMBY, Yaima Luzardo LIGHTFOOT, Philip JONES, Russell THOMAS, Chiara LIBERATI, Domenica TORINO, Valentina CUSANO, Francesco PISCITELLI, Ali Munaim YOUSIF, Silvia BOVOLENTA