Patents by Inventor Dominique Soldati

Dominique Soldati has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tet transactivator system
    Publication number: 20030185851
    Abstract: A transcriptional activator of T. gondii is provided which comprises the tetracycline repressor (TetR) operatively linked to a transacting factor of T. gondii. Strains of T. gondii transformed with a vector containing such a transactivator may be used to prepare vaccine compositions or to identify essential genes in the parasite. The system provided may be useful in other Apicomplexan species such as Plasmodium falciparum, Plasmodium vivax, Plasmodium berghei, Plasmodium yoelii, Plasmodium knowlesi, Trypanosoma brucei, Entamoeba histolytica, and Giardia lambia.
    Type: Application
    Filed: March 20, 2002
    Publication date: October 2, 2003
    Inventors: Dominique Soldati, Markus Meissner
  • Transfection and genetic manipulations in obligate intracellular parasites
    Patent number: 5976553
    Abstract: A method of transient transfection of obligate intracellular parasites is described. This method is exploited to develop a system for stable transformation utilizing selectable genes. For example, introduction of the chloramphenicol acetyl transferase (CAT) gene fused to Toxoplasma flanking sequences followed by chloramphenicol selection results in parasites stably expressing CAT. DNA hybridization analysis indicated that the CAT gene had inserted via homologous recombination.
    Type: Grant
    Filed: May 31, 1996
    Date of Patent: November 2, 1999
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Kami Kim, Dominique Soldati, John C. Boothroyd
  • Transfection and genetic manipulations in obligate intracellular parasites
    Patent number: 5643718
    Abstract: A method of transient transfection of obligate intracellular parasites is described. This method is exploited to develop a system for stable transformation utilizing selectable genes. For example, introduction of the chloramphenicol acetyl transferase (CAT) gene fused to Toxoplasma flanking sequences followed by chloramphenicol selection results in parasites stably expressing CAT. DNA hybridization analysis indicated that the CAT gene had inserted via homologous recombination.
    Type: Grant
    Filed: November 4, 1993
    Date of Patent: July 1, 1997
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Kami Kim, Dominique Soldati, John C. Boothroyd