Patents by Inventor Donald E. Awrey

Donald E. Awrey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indazole compounds as kinase inhibitors and method of treating cancer with same
    Patent number: 9580390
    Abstract: The present teaching provide indazole compounds represented by Structural Formulae (I) or (I?) or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof as protein kinase inhibitors, such as TTK protein kinase, polo-like kinase 4 (PLK4) and Aurora kinases having anticancer activity against breast cancer cells, colon cancer cells, and ovarian cancer cells.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: February 28, 2017
    Assignee: University Health Network
    Inventors: Heinz W. Pauls, Radoslaw Laufer, Yong Liu, Sze-Wan Li, Bryan T. Forrest, Yunhui Lang, Narendra Kumar B. Patel, Louise G. Edwards, Grace Ng, Peter Brent Sampson, Miklos Feher, Donald E. Awrey
  • INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME
    Publication number: 20140371202
    Abstract: The present teaching provide indazole compounds represented by Structural Formulae (I) or (I?) or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof as protein kinase inhibitors, such as TTK protein kinase, polo-like kinase 4 (PLK4) and Aurora kinases having anticancer activity against breast cancer cells, colon cancer cells, and ovarian cancer cells.
    Type: Application
    Filed: October 12, 2012
    Publication date: December 18, 2014
    Applicant: University Health Network
    Inventors: Heinz W. Pauls, Radoslaw Laufer, Yong Liu, Sze-Wan Li, Bryan T. Forrest, Yunhui Lang, Narendra Kumar B. Patel, Louise G. Edwards, Grace Ng, Peter Brent Sampson, Miklos Feher, Donald E. Awrey
  • KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME
    Publication number: 20140051679
    Abstract: The present teachings provide a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.
    Type: Application
    Filed: October 12, 2012
    Publication date: February 20, 2014
    Applicant: UNIVERISTY HEALTH NETWORKS
    Inventors: Heinz W. Pauls, Radoslaw Laufer, Yong Liu, Sze-Wan Li, Bryan T. Forrest, Yunhui Lang, Narendra Kumar B. Patel, Louise G. Edwards, Grace Ng, Peter B. Sampson, Miklos Feher, Donald E. Awrey
  • Purified polypeptides from
    Patent number: 7799547
    Abstract: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 4. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
    Type: Grant
    Filed: January 11, 2006
    Date of Patent: September 21, 2010
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Donald E. Awrey, Teresa Clarke McGrath, Vladimir Romanov
  • Purified FabI polypeptides from
    Patent number: 7601526
    Abstract: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein derived from Fransicella tularensis comprising the amino acid sequence set forth in SEQ ID NO: 2. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: October 13, 2009
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Judd M. Berman, Molly B. Schmid, Donald E. Awrey, Teresa Clarke, Bryan Beattie, Mandy Dorsey
  • Novel purified FabI polypeptides from fransicella tularensis
    Publication number: 20080108793
    Abstract: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 2. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.
    Type: Application
    Filed: December 28, 2006
    Publication date: May 8, 2008
    Inventors: Judd M. Berman, Molly B. Schmid, Donald E. Awrey, Teresa Clarke McGrath, Bryan Beattie, Mandy Dorsey
  • Methods for systematic identification of protein—protein interactions
    Patent number: 6797523
    Abstract: The present invention relates to a method for identifying protein—protein interactions. The interacting proteins are isolated by affinity chromatography and identified by mass spectrometry. The affinity chromatography method allows for the purification of unknown interacting proteins which are identified using mass spectrometric techniques. The invention provides a method for the high throughput analysis of protein—protein interactions that lends itself to automation.
    Type: Grant
    Filed: November 30, 2000
    Date of Patent: September 28, 2004
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Donald E. Awrey, Jack Greenblatt
  • High throughput purification, characterization and identification of recombinant proteins
    Publication number: 20040033530
    Abstract: The invention provides high throughput assays for rapidly and simultaneously purifying, quantifying, determining the solubility profile, determining the purity and identifying a plurality of recombinant proteins. The method comprises affinity protein purification; proteolytic digestion and analysis of the protein fragments by mass spectrometry in multi-well plates.
    Type: Application
    Filed: April 8, 2003
    Publication date: February 19, 2004
    Inventors: Donald E. Awrey, Daniel Mamelak, Aled Edwards, Akil I. Dharamsi
  • Methods for systematic identification of protein - protein interactions
    Publication number: 20020102741
    Abstract: The present invention relates to a method for identifying protein-protein interactions. The interacting proteins are isolated by affinity chromatography and identified by mass spectrometry. The affinity chromatography method allows for the purification of unknown interacting proteins which are identified using mass spectrometric techniques. The invention provides a method for the high throughput analysis of protein-protein interactions that lends itself to automation.
    Type: Application
    Filed: November 30, 2000
    Publication date: August 1, 2002
    Inventors: Donald E. Awrey, Jack Greenblatt