Patents by Inventor Donald E. Ingber

Donald E. Ingber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10293023
    Abstract: Provided here are methods of modulating vascular permeability by changing the mechanical properties of extracellular matrices (ECM) and methods of treatment of diseases, conditions and symptoms related to vascular permeability such as pulmonary edema and acute respiratory distress syndrome (ARDS). The modulation can be increasing or decreasing vascular permeability. Vascular leakage can be normalized by increasing or decreasing ECM stiffness depending on the baseline mechanical properties of the tissue or organ. Vascular permeability is altered by changing the mechanical properties of ECM by administering a lysyl oxidase modulating (LOX) agent.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 21, 2019
    Assignee: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Donald E. Ingber, Akiko Mammoto
  • Publication number: 20190144567
    Abstract: This disclosure provides, e.g., methods for coupling an entity to a solid substrate. The method can comprise treating the substrate with a plasma, e.g., a CO2 plasma, to increase its reactivity. The entity can be, e.g., a biological polymer that binds a microbe. Substrates produced by these methods can be used in a variety of applications, including hemodialysis and diagnostic assays.
    Type: Application
    Filed: May 16, 2017
    Publication date: May 16, 2019
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Daniel Christopher LESLIE, Thomas DOYLE, Anna WATERHOUSE, Melissa RODAS, Alexander L. WATTERS, Michael SUPER, Donald E. INGBER
  • Publication number: 20190106665
    Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.
    Type: Application
    Filed: September 18, 2018
    Publication date: April 11, 2019
    Inventors: Donald E. Ingber, Anthony Bahinski, Robert Cunningham, Josue A. Goss, Geraldine A. Hamilton, Christopher David Hinojosa, Daniel Levner, Kevin Kit Parker
  • Publication number: 20190077850
    Abstract: Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. The microbe-targeting or microbe-binding molecules can comprise a microbe surface-binding domain linked to a portion of an Fc region. Further, the microbe-targeting molecules can be conjugated to substrate (e.g., a magnetic particle) to form a microbe-targeting substrate. Such microbe-targeting molecules and/or substrates and the kits comprising the same can be used in various applications, such as diagnosis and/or treatment of an infection caused by microbes. Moreover, the microbe-targeting molecules and/or substrates can be easily regenerated after use.
    Type: Application
    Filed: August 9, 2018
    Publication date: March 14, 2019
    Inventors: Donald E. Ingber, Michael Super, Alexander Watters
  • Patent number: 10202569
    Abstract: A microfluidic device for simulating a function or response of a tissue is disclosed. The device includes an inlet for receiving a fluid in the device, and an outlet for removing the fluid from the device. The device further includes a fluid channel in fluid communication with the inlet and the outlet for flowing the fluid through the device. The fluid channel defines a chamber well that receives cells associated with the tissue. The device also includes an interface structure between the fluid channel and the chamber well for permitting migration of at least one of cells, particulates, chemicals, molecules, liquids, or gases between the fluid within the fluid channel and the chamber well.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: February 12, 2019
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Richard Novak, David Conegliano, Liliana Teixeira, Donald E. Ingber
  • Publication number: 20190032021
    Abstract: Disclosed herein are organ chips that can be individually used or integrated together to form different microphysiological systems, e.g., for use in cell culturing, drug screening, toxicity assays, personalized therapeutic treatment, scaffolding in tissue repair and/or replacement, and/or pharmacokinetic or pharmacodynamics studies.
    Type: Application
    Filed: September 7, 2018
    Publication date: January 31, 2019
    Inventors: Donald E. Ingber, Kevin Kit Parker, Geraldine A. Hamilton, Anthony Bahinski
  • Publication number: 20190025240
    Abstract: A method of fabricating electrodes includes forming a first metallic film layer on an upper surface of a first material substrate, and attaching a first polymeric layer to the upper surface of the first material substrate to form a first opened microchannel. The method further includes forming a second metallic film layer on a portion of a lower surface of a second material substrate, and attaching a second polymeric layer to the lower surface of the second material substrate to form a second opened microchannel. The method also includes attaching the first opened microchannel to a bottom side of the membrane and the second opened microchannel to the top side of the membrane. The first metallic film layer and the second metallic film layer each constitute transparent electrodes and are positioned with the membrane therebetween.
    Type: Application
    Filed: December 16, 2016
    Publication date: January 24, 2019
    Inventors: Olivier Henry, Andries van der Meer, Donald E. Ingber
  • Publication number: 20190009274
    Abstract: Described herein are microfluidic devices and systems for high density cell culture and/or high throughput cell assays. Methods of using the same are also provided herein. In some embodiments, the microfluidic devices and systems described herein provide rapid and automated trapping of single embryos in ordered arrays.
    Type: Application
    Filed: August 12, 2016
    Publication date: January 10, 2019
    Applicants: President and Fellows of Harvard College, Tufts University
    Inventors: Richard Novak, Donald E. Ingber, Michael Levin, Rachelle Prantil-Baun
  • Publication number: 20190002527
    Abstract: TRPV4 activation increases vascular permeability and can be triggered by both chemical and mechanical cues. This activation of TRPV4 can contribute to a number of pathological conditions, e.g., edema, inflammation, hypertension, and/or hyperalgesia. Described herein are methods and compositions relating to inhibition of mechanically-induced TRPV4 activation, e.g., for the treatment of pulmonary edema, edema, inflammation, hypertension, and/or hyperalgesia.
    Type: Application
    Filed: July 13, 2018
    Publication date: January 3, 2019
    Applicant: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Donald E. INGBER, Mariko KOBAYASHI
  • Publication number: 20180371058
    Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can not only bind or capture of a microbe or microbial matter thereof, but they also have improved capability (e.g., enhanced sensitivity or signal intensity) of detecting a microbe or microbial matter. Thus, the microbe-targeting molecules, microbe-targeting articles, and/or the kit described herein can be used in various applications, e.g., but not limited to assays for detection of a microbe or microbial matter, diagnostic and/or therapeutic agents for diagnosis and/or treatment of an infection caused by microbes in a subject or any environmental surface, and/or devices for removal of a microbe or microbial matter from a fluid.
    Type: Application
    Filed: August 4, 2016
    Publication date: December 27, 2018
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Alexander WATTERS, Brendon Dusel, Michael SUPER, Mark CARTWRIGHT, Donald E. INGBER
  • Publication number: 20180361062
    Abstract: A physiologic sensor module includes at least one wearable sensor that is configured for wearing on a human body part and for measuring at least one biological signal. The module further includes at least one controller communicatively coupled to the wearable sensor and configured to receive the biological signal from the wearable sensor. The controller is further configured to process the biological signal in real-time, extract one or more clinical features from the biological signal, and based on the clinical features, determine detection of anaphylaxis.
    Type: Application
    Filed: August 22, 2018
    Publication date: December 20, 2018
    Inventors: Andy H. Levine, Christoph Matthias Kanzler, Aymeric Guy, Daniel Leo Miranda, Joseph Mooney, Adam Zapotok, Samuel Berry, Huy Lam, Jonathan Sabaté del Río, John Osborne, Mustafa Karabas, Alan Dunne, James Niemi, Benjamin Matthews, Donald E. Ingber, Olivier Henry, Premananda Pai Indic
  • Publication number: 20180346859
    Abstract: A device for simulating a function of a tissue includes a first structure, a second structure, and a membrane. The first structure defines a first chamber. The first chamber includes a matrix disposed therein and an opened region. The second structure defines a second chamber. The membrane is located at an interface region between the first chamber and the second chamber. The membrane includes a first side facing toward the first chamber and a second side facing toward the second chamber. The membrane separates the first chamber from the second chamber.
    Type: Application
    Filed: December 2, 2016
    Publication date: December 6, 2018
    Inventors: Antonio Varone, Norman Wen, Daniel Levner, Richard Novak, Lori McPartlin, Donald E. Ingber, Youngjae Choe, Lian Leng, Justin K. Nguyen
  • Publication number: 20180346867
    Abstract: A low-oxygen system is directed to culturing a diverse microbiome and includes an anaerobic chamber and at least one microfluidic device removably inserted in the anaerobic chamber. The microfluidic device includes a first microchannel in which a first level of oxygen is maintained, and a second microchannel in which a second level of oxygen is maintained, the second level of oxygen having a greater oxygen concentration than the first level of oxygen. The microfluidic device further includes a membrane located at an interface region between the first microchannel and the second microchannel, the membrane further having a plurality of pores via which oxygen flows from the second microchannel to the first microchannel to form an oxygen gradient in the first microchannel. The system further includes a culture system provided in the first microchannel and including oxygen-sensitive anaerobic bacteria.
    Type: Application
    Filed: November 14, 2016
    Publication date: December 6, 2018
    Inventors: John W. K. OLIVER, Richard NOVAK, Michael J. CRONCE, Donald E. INGBER, Jeffrey C. WAY
  • Publication number: 20180333533
    Abstract: An injector module includes a housing, a reservoir, a superelastic needle, and an actuator. The reservoir is positioned in the housing and stores epinephrine therein. The superelastic needle is positioned within the housing in a retracted position and is fluidly coupled with the reservoir. The superelastic needle has a gauge between eighteen and twenty-five. The actuator is configured to apply an actuator force on the superelastic needle such that the superelastic needle is moved from the retracted position to an injecting position where a tip of the superelastic needle protrudes from the housing between about fifteen millimeters and about thirty-five millimeters.
    Type: Application
    Filed: May 4, 2018
    Publication date: November 22, 2018
    Inventors: Andy H. Levine, Cristoph Matthias Kanzler, Aymeric Guy, Daniel Leo Miranda, Joseph Mooney, Adam Zapotok, Samuel Berry, Huy Lam, Jonathan Sabaté del Río, John Osborne, Mustafa Karabas, Alan Dunne, James Niemi, Benjamin Matthews, Donald E. Ingber, Olivier Henry, Premananda Pai Indic
  • Publication number: 20180320157
    Abstract: Described herein are heme-binding compositions and methods relating to their use, e.g. methods of treatment of, for example, sepsis and rhabdomyolysis.
    Type: Application
    Filed: May 1, 2018
    Publication date: November 8, 2018
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Michael SUPER, Alexander L. WATTERS, Philip T. SNELL, Donald E. INGBER
  • Publication number: 20180298317
    Abstract: Systems and methods for producing and using a body having a first structure defining a first chamber, a second structure defining a second chamber, a membrane located at an interface region between the first chamber and the second chamber to separate the first chamber from the second chamber. The first chamber comprises a first permeable matrix disposed therein and the first permeable matrix comprises at least one or a plurality of lumens each extending therethrough, which is optionally lined with at least one layer of cells. The second chamber can comprise cells cultured therein. The systems and methods described herein can be used for various applications, including, e.g., growth and/or differentiation of primary cells, and/or simulation of a microenvironment in living tissues and/or organs (to model physiology or disease states, and/or to identify therapeutic agents). The systems and methods can also permit co-cultures of two or more different cell types.
    Type: Application
    Filed: April 25, 2016
    Publication date: October 18, 2018
    Inventors: Donald E. INGBER, Andries VAN DER MEER, Anna HERLAND
  • Patent number: 10087422
    Abstract: Disclosed herein are organ chips that can be individually used or integrated together to form different microphysiological systems, e.g., for use in cell culturing, drug screening, toxicity assays, personalized therapeutic treatment, scaffolding in tissue repair and/or replacement, and/or pharmacokinetic or pharmacodynamics studies.
    Type: Grant
    Filed: December 10, 2012
    Date of Patent: October 2, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: Donald E. Ingber, Kevin Kit Parker, Geraldine A. Hamilton, Anthony Bahinski
  • Patent number: 10080841
    Abstract: A physiologic sensor module includes at least one wearable sensor that is configured for wearing on a human body part and for measuring at least one biological signal. The module further includes at least one controller communicatively coupled to the wearable sensor and configured to receive the biological signal from the wearable sensor. The controller is further configured to process the biological signal in real-time, extract one or more clinical features from the biological signal, and based on the clinical features, determine detection of anaphylaxis.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: September 25, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: Andy H. Levine, Christoph Matthias Kanzler, Daniel Leo Miranda, Joseph Mooney, Huy Lam, John Osborne, Mustafa Karabas, Alan Dunne, James Niemi, Benjamin Matthews, Donald E. Ingber, Olivier Henry, Premananda Pai Indic
  • Patent number: 10047140
    Abstract: TRPV4 activation increases vascular permeability and can be triggered by both chemical and mechanical cues. This activation of TRPV4 can contribute to a number of pathological conditions, e.g., edema, inflammation, hypertension, and/or hyperalgesia. Described herein are methods and compositions relating to inhibition of mechanically-induced TRPV4 activation, e.g., for the treatment of pulmonary edema, edema, inflammation, hypertension, and/or hyperalgesia.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: August 14, 2018
    Assignee: CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Donald E. Ingber, Mariko Kobayashi
  • Publication number: 20180216074
    Abstract: The technology described herein is directed to methods and devices that can be used to induce functional organ structures to form within an implantation device by implanting it in vivo within the body of a living animal, and allowing cells and tissues to impregnate the implantation device and establish normal microenvironmental architecture and tissue-tissue interfaces. Then the contained cells and tissues can be surgically removed intact and either transplanted into another animal or maintained ex vivo by perfusing it through one or more of the fluid channels with medium and/or gases necessary for cell survival.
    Type: Application
    Filed: March 26, 2018
    Publication date: August 2, 2018
    Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, CHILDREN'S MEDICAL CENTER CORPORATION
    Inventors: Donald E. Ingber, Yusuke Torisawa, Geraldine Hamilton, Akiko Mammoto, Tadanori Mammoto, Catherine Spina