Patents by Inventor Donald M. Engelman

Donald M. Engelman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FLUORESCENT COMPOUND COMPRISING A FLUOROPHORE CONJUGATED TO A pH-TRIGGERED POLYPEPTIDE
    Publication number: 20240075170
    Abstract: The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided.
    Type: Application
    Filed: July 10, 2023
    Publication date: March 7, 2024
    Inventors: Yana K. RESHETNYAK, Oleg A. ANDREEV, Donald M. ENGELMAN
  • pHLIP® peptide mediated epitope tethering at cell surfaces
    Publication number: 20240066096
    Abstract: The invention features methods and compositions for eliciting an anti-tumor response in a subject comprising administering to the subject a pHLIP? construct comprising an antibody recruiting molecule linked to one or more pHLIP? peptides by a non-cleavable linker compound. The construct increases the amount of the antibody recruiting molecule on the surface of a diseased cell.
    Type: Application
    Filed: May 30, 2023
    Publication date: February 29, 2024
    Inventors: Yana K. RESHETNYAK, Oleg A. ANDREEV, Anna MOSHNIKOVA, Donald M. Engelman
  • LINKED AND OTHER pH-TRIGGERED COMPOUNDS
    Publication number: 20240042063
    Abstract: Provided herein are, inter alia, pH-triggered compounds and compositions comprising one or more peptides that are capable of inserting into a lipid bilayer below a certain pH. Treatment, imaging, diagnostic, and other uses of such compounds and compositions are also provided.
    Type: Application
    Filed: June 8, 2023
    Publication date: February 8, 2024
    Inventors: Yana K. RESHETNYAK, Oleg A. ANDREEV, Donald M. ENGELMAN
  • Liposome compositions and methods of use thereof
    Patent number: 11857509
    Abstract: The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the pHLIP polypeptide.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: January 2, 2024
    Assignees: University of Rhode Island Board of Trustees, Yale University
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman
  • Fluorescent compound comprising a fluorophore conjugated to a pH-triggered polypeptide
    Patent number: 11779662
    Abstract: The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: October 10, 2023
    Assignees: University of Rhode Island Board of Trustees, Yale University
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman
  • Method of detecting diseased or damaged tissue with a pH-triggered polypeptide fluorophore composition
    Patent number: 11738096
    Abstract: The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: August 29, 2023
    Assignees: Yale University, University of Rhode Island Board of Trustees
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman
  • PHLIP®-MEDIATED INTRACELLULAR DELIVERY OF IMMUNO-STIMULATORY COMPOUNDS
    Publication number: 20220088208
    Abstract: The invention features a composition comprising an immuno-stimulatory compound and a pHLIP® peptide, e.g., an immunostimulatory compound that comprises a cyclic purine dinucleotide, which binds to a stimulator of interferon genes (STING) such as a cGAMP cyclic compound inside a cell.
    Type: Application
    Filed: January 28, 2020
    Publication date: March 24, 2022
    Applicants: University of Rhode Island Board of Trustees, Yale University
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman, Anna Moshnikova, John Deacon
  • Carbohydrate tethering at cell surfaces to induce immune response
    Patent number: 11267853
    Abstract: The invention features a compositions and methods for inducing an immune response to targeted cells. The compositions induce targeting of a cell by positioning carbohydrate epitopes on the surface of the cell by conjugation of the epitope to a pH-triggered membrane peptide (pHLIP®).
    Type: Grant
    Filed: January 28, 2020
    Date of Patent: March 8, 2022
    Assignees: University of Rhode Island Board of Trustees, Yale University
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Anna Moshnikova, Donald M. Engelman
  • Environmentally sensitive compositions comprising a pH-triggered membrane protein and methods of use thereof in the treatment and diagnosis of tumors
    Patent number: 11229710
    Abstract: An environmentally sensitive membrane binding polypeptide, pH (low)-sensitive membrane peptide (pHLIP) has improved insertion kinetics balanced with solubility to selectively target acidic tissues.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: January 25, 2022
    Assignees: University of Rhode Island Board of Trustees, Yale University
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman
  • RADIOLABELED LIGANDS FOR TARGETED PET/SPECT IMAGING AND METHODS OF THEIR USE
    Publication number: 20210283281
    Abstract: The present disclosure provides compounds, complexes, compositions, and methods for the detection of cancer. Specifically, the compounds, complexes, compositions of the present technology include pH (low) insertion peptides. Also disclosed herein are methods of using the complexes and compositions of the present technology in diagnostic imaging to detect cancer in a subject.
    Type: Application
    Filed: July 29, 2017
    Publication date: September 16, 2021
    Applicants: MEMORIAL SLOAN KETTERING CANCER CENTER, RHODE ISLAND COUNCIL ON POSTSECONDARY EDUCATION, PHLIP, INC.
    Inventors: Jason S. LEWIS, Dustin DEMOIN, Yana K. RESHETNYAK, Oleg A. ANDREEV, Donald M. ENGELMAN, Narissa VIOLA-VILLEGAS
  • PHLIP®-MEDIATED TARGETING OF CORTICOSTEROIDS TO DISEASED TISSUE
    Publication number: 20200323882
    Abstract: The invention features a composition comprising a corticosteroid and a pHLIP® peptide. pHLIP® peptides target corticosteroids to cell surface acidity in inflamed and fibrotic tissues, where they translocate corticosteroids across plasma membranes into the cytoplasms of cells, thereby suppressing inflammation in the targeted tissues while avoiding the side effects resulting from non-targeted administration.
    Type: Application
    Filed: March 13, 2020
    Publication date: October 15, 2020
    Inventors: Yana K. Reshetnyak, David Wolfsohn, Anna Moshnikova, Oleg A. Andreev, Donald M. Engelman
  • pHLIP-Mediated Carbohydrate Tethering at Cell Surfaces to Induce Immune Response
    Publication number: 20200262881
    Abstract: The invention features a compositions and methods for inducing an immune response to targeted cells. The compositions induce targeting of a cell by positioning carbohydrate epitopes on the surface of the cell by conjugation of the epitope to a pH-triggered membrane peptide (pHLIP®).
    Type: Application
    Filed: January 28, 2020
    Publication date: August 20, 2020
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Anna Moshnikova, Donald M. Engelman
  • LIPOSOME COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20200253872
    Abstract: The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the pHLIP polypeptide.
    Type: Application
    Filed: December 17, 2019
    Publication date: August 13, 2020
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman
  • pHLIP® peptide-mediated epitope tethering at cell surfaces
    Publication number: 20200246420
    Abstract: The invention features methods and compositions for eliciting an anti-tumor response in a subject comprising administering to the subject a pHLIP® construct comprising an antibody recruiting molecule linked to one or more pHLIP® peptides by a non-cleavable linker compound. The construct increases the amount of the antibody recruiting molecule on the surface of a diseased cell.
    Type: Application
    Filed: January 28, 2020
    Publication date: August 6, 2020
    Applicants: Rhode Island Council on Postsecondary Education, Yale University, Yale University
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Anna Moshnikova, Donald M. Engelman
  • pHLIP® targeted delivery of potent cytotoxic compounds
    Publication number: 20200237926
    Abstract: The invention features a composition comprising a potent cytotoxic compound and a pHLIP® peptide, where, e.g., the cytotoxic compound cannot be used alone due to a lack of targeting. pHLIP® peptide targets cytotoxic compounds to acidic diseased tissue, translocates cytotoxic compounds across plasma membranes into the cytosols of cells in acidic diseased tissues and induces cell death predominantly in the targeted acidic diseased tissue.
    Type: Application
    Filed: January 28, 2020
    Publication date: July 30, 2020
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Anna Moshnikova, Donald M. Engelman
  • Liposome structures and methods of use thereof
    Patent number: 10512606
    Abstract: The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the pHLIP polypeptide.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: December 24, 2019
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman
  • FLUORESCENT COMPOUND COMPRISING A FLUOROPHORE CONJUGATED TO A PH-TRIGGERED POLYPEPTIDE
    Publication number: 20190231904
    Abstract: The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided.
    Type: Application
    Filed: September 22, 2017
    Publication date: August 1, 2019
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman
  • LINKED AND OTHER pH-TRIGGERED COMPOUNDS
    Publication number: 20180369425
    Abstract: Provided herein are, inter alia, pH-triggered compounds and compositions comprising one or more peptides that are capable of inserting into a lipid bilayer below a certain pH. Treatment, imaging, diagnostic, and other uses of such compounds and compositions are also provided.
    Type: Application
    Filed: June 11, 2018
    Publication date: December 27, 2018
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman
  • Environmentally Sensitive Compositions and Methods of Use Thereof
    Publication number: 20180221500
    Abstract: An environmentally sensitive membrane binding polypeptide, pH (low)-sensitive membrane peptide (pHLIP) has improved insertion kinetics balanced with solubility to selectively target acidic tissues.
    Type: Application
    Filed: November 13, 2017
    Publication date: August 9, 2018
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman
  • FLUORESCENT COMPOUND COMPRISING A FLUOROPHORE CONJUGATED TO A pH-TRIGGERED POLYPEPTIDE
    Publication number: 20180117183
    Abstract: The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided.
    Type: Application
    Filed: September 22, 2017
    Publication date: May 3, 2018
    Inventors: Yana K. Reshetnyak, Oleg A. Andreev, Donald M. Engelman