Patents by Inventor Donald W. Hansen

Donald W. Hansen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterobicyclic and tricyclic nitric oxide synthase inhibitors
    Publication number: 20010044539
    Abstract: The current invention discloses useful bicyclic and tricyclic amidino derivative compounds, pharmaceutical compositions containing these novel compounds, and to their use as nitric oxide synthase inhibitors.
    Type: Application
    Filed: March 26, 2001
    Publication date: November 22, 2001
    Inventors: Donald W. Hansen, R. Keith Webber, E. Ann Hallinan, Mihaly V. Toth, Barnett S. Pitzele, Alok K. Awasthi, Alan E. Moormann, Suzanne Metz, Jeffery S. Snyder, William M. Moore, Jeffrey A. Scholten
  • Process for the enzymatic resolution of lactams
    Patent number: 6277626
    Abstract: A method of separating enantiomeric lactam esters. The lactam esters are contacted with a biocatalyst, such as an enzyme or a microorganism, in a solution wherein only one enantiomer is selectively hydrolyzed to give the optically active isomer of the corresponding acid. The hydrolysis product is then separated from the unreacted lactam esters. The enzyme is then recycled for reuse in the next enzymatic resolution. The undesired isomer is also racemized and reused in the next enzymatic resolution.
    Type: Grant
    Filed: February 16, 1999
    Date of Patent: August 21, 2001
    Assignee: G.D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., Mahima Trivedi, Rolando E. Gapud, John S. Ng, Alok K. Awasthi, Ping T. Wang
  • Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors
    Patent number: 6207708
    Abstract: The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: March 11, 1998
    Date of Patent: March 27, 2001
    Assignee: G. D. Searle & Company
    Inventors: Rolando E. Gapud, Timothy J. Hagen, E. Ann Hallinan, Donald W. Hansen, Jr., Barnett S. Pitzele, Suzanne S. Metz, R. Keith Webber, Foe S. Tjoeng, Robert E. Manning, Mihaly V. Toth
  • Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
    Patent number: 6169089
    Abstract: The current invention discloses aminotetrazole derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: March 12, 1999
    Date of Patent: January 2, 2001
    Assignee: G. D. Searle & Company
    Inventors: E. Ann Hallinan, Donald W. Hansen, Jr., Sofya Tsymbalov
  • Oxathiadiazole derivatives usful as iNOS inhibitors
    Patent number: 6136829
    Abstract: 1,3-diazolino and 1,3-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: July 19, 1999
    Date of Patent: October 24, 2000
    Assignee: G.D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., Ariia A. Bergmanis, Timothy J. Hagen, E. Ann Hallinan, Steven W. Kramer, Suzanne Metz, Karen B. Peterson, Barnett S. Pitzele, Foe S. Tjoeng, Mihaly V. Toth, Mahima Trivedi, R. Keith Webber, Sofya Tsymbalov, Rolando E. Gapud
  • Imidino piperidine derivatives useful as nitric oxide synthase inhibitors
    Patent number: 6071906
    Abstract: The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: July 28, 1998
    Date of Patent: June 6, 2000
    Assignee: G. D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., Mark G. Currie, E. Ann Hallinan, Kam F. Fok, Timothy J. Hagen, Arija A. Bergmanis, Steven W. Kramer, Len F. Lee, Suzanne Metz, William M. Moore, Karen B. Peterson, Barnett S. Pitzele, Dale P. Spangler, R. Keith Webber, Mihaly V. Toth, Mahima Trivedi, Foe S. Tjoeng
  • Amidino derivatives useful as nitric oxide synthase inhibitors
    Patent number: 6046211
    Abstract: The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: May 6, 1998
    Date of Patent: April 4, 2000
    Assignee: G.D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., Mark G. Currie, E. Ann Hallinan, Kam F. Fok, Timothy J. Hagen, Arija A. Bergmanis, Steven W. Kramer, Len F. Lee, Suzanne Metz, William M. Moore, Karen B. Peterson, Barnett S. Pitzele, Dale P. Spangler, R. Keith Webber, Mihaly V. Toth, Mahima Trivedi, Foe S. Tjoeng
  • Pyrrolodino imidines useful as nitric oxide synthase inhibitors
    Patent number: 6043261
    Abstract: The current invention discloses useful pyrrolodino imidine derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: November 25, 1998
    Date of Patent: March 28, 2000
    Assignee: G. D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., E. Ann Hallinan, Timothy J. Hagen, Steven W. Kramer, Suzanne Metz, Karen B. Peterson, Dale P. Spangler, Mihaly V. Toth, Kam F. Fok, Arija A. Bergmanis, R. Keith Webber, Mahima Trivedi, Foe S. Tjoeng, Barnett S. Pitzele
  • Cyclic amidino agents useful as nitric oxide synthase inhibitors
    Patent number: 6011028
    Abstract: The current invention discloses useful amidino derivative useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: March 27, 1998
    Date of Patent: January 4, 2000
    Assignee: G.D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., E. Ann. Hallinan, Timothy J. Hagen, Steven W. Kramer, Suzanne Metz, Karen B. Peterson, Dale P. Spangler, Mihaly V. Toth, Kam F. Fok, Arija A. Bergmanis, R. Keith Webber, Mahima Trivedi, Foe S. Tjoeng, Barnett S. Pitzele
  • Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors
    Patent number: 5981511
    Abstract: The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: March 5, 1997
    Date of Patent: November 9, 1999
    Assignee: G.D. Searle & Co.
    Inventors: Rolando E. Gapud, Timothy J. Hagen, Ann E. Hallinan, Donald W. Hansen, Jr., Robert E. Manning, Suzanne Metz, Barnett S. Pitzele, Foe S. Tjoeng, Mihaly V. Toth, R. Keith Webber
  • 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors
    Patent number: 5981556
    Abstract: 1,3-diazolino and 1,3-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: July 22, 1997
    Date of Patent: November 9, 1999
    Assignee: G.D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., Arija A. Bergmanis, Timothy J. Hagen, E. Ann Hallinan, Steven W. Kramer, Suzanne Metz, Karen B. Peterson, Barnett S. Pitzele, Foe S. Tjoeng, Mihaly V. Toth, Mahima Trivedi, R. Keith Webber, Sofya Tsymbalov, Rolando E. Gapud
  • 1,2,4-oxa diazolino and 1,24-oxa diazolidion heterocycles as useful nitric oxide synthase inhibitors
    Patent number: 5958958
    Abstract: 1,2,4-oxa-diazolino and 1,2,4-oxa-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: January 14, 1999
    Date of Patent: September 28, 1999
    Assignee: G.D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., Arija A. Bergmanis, Timothy J. Hagen, E. Ann Hallinan, Steven W. Kramer, Suzanne Metz, Karen B. Peterson, Barnett S. Pitzele, Foe S. Tjoeng, Mihaly V. Toth, Mahima Trivedi, R. Keith Webber, Sofya Tsymbalov, Rolando E. Gapud
  • Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
    Patent number: 5919787
    Abstract: The current invention discloses aminotetrazole derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: October 5, 1998
    Date of Patent: July 6, 1999
    Assignee: G. D. Searle & Co.
    Inventors: E. Ann Hallinan, Donald W. Hansen, Jr., Sofya Tsymbalov
  • Azepine derivatives useful as nitric oxide synthase inhibitors
    Patent number: 5883251
    Abstract: The current invention discloses azepine derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: March 16, 1999
    Assignee: G. D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., E. Ann Hallinan, Timothy J. Hagen, Steven W. Kramer, Suzanne Metz, Karen B. Peterson, Dale P. Spangler, Mihaly V. Toth, Kam F. Fok, Arija A. Bergmanis, R. Keith Webber, Mahima Trivede, Foe S. Tjoeng, Barnett S. Pitzele
  • Amidino dervatives useful as nitric oxide synthase inhibitors
    Patent number: 5854234
    Abstract: The current invention discloses useful pharmaceutical compositions containing azepine derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 29, 1998
    Assignee: G. D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., Mark G. Currie, E. Ann Hallinan, Kam F. Fok, Timothy J. Hagen, Arija A. Bergmanis, Steven W. Kramer, Len F. Lee, Suzanne Metz, William M. Moore, Karen B. Peterson, Barnett S. Pitzele, Dale P. Spangler, R. Keith Webber, Mihaly V. Toth, Mahima Trivedi, Foe S. Tjoeng
  • Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
    Patent number: 5854251
    Abstract: Aminotetrazole derivatives of the formula (I) wherein the variables are as defined in the disclosure are useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: April 30, 1997
    Date of Patent: December 29, 1998
    Assignee: G. D. Searle & Co.
    Inventors: Ann E. Hallinan, Donald W. Hansen, Jr., Sofya Tsymbalov
  • Imidazo?1,2-a! Pyridinyldiacid compounds for cognitive enhancement and for treatment of cognitive disorders and neurotoxic injury
    Patent number: 5721223
    Abstract: A class of imidazo?1,2-a!pyridinyldiacid compounds is described for cognitive enhancement and for treatment of cognitive disorders and which have activity as a cognitive enhancer. Such compounds are also useful to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of a compound of this class alone or in a composition in an amount effective as an agonist or partial agonist to modulate, or as an antagonist to inhibit, excitotoxic actions at major neuronal excitatory amino acid receptor sites. Compounds of most interest are those of the formula: ##STR1## wherein each R.sup.20 is independently selected from hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl; wherein each of Y.sub.m and Y.sub.
    Type: Grant
    Filed: October 3, 1995
    Date of Patent: February 24, 1998
    Inventors: Donald W. Hansen, Jr., Karen B. Peterson, Joseph B. Monahan
  • Tetrazolyl substituted imidazo?1,2-a!pyridinylalkyl compounds for treatment of neurotoxic injury
    Patent number: 5716964
    Abstract: A class of imidazo?1,2-a!pyridinylalkyl compounds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of a compound of this class alone or in a composition in an amount effective as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites. Compounds of most interest are those of the formula: ##STR1## wherein each of R.sup.22, R.sup.23 and R.sup.24 is independently selected from hydrido, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl; wherein each of Y.sub.m and Y.sub.
    Type: Grant
    Filed: April 18, 1995
    Date of Patent: February 10, 1998
    Assignee: G.D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., Gilbert W. Adelstein, Karen B. Peterson, Sofya Tsymbalov
  • Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
    Patent number: 5684008
    Abstract: The current invention discloses aminotetrazole derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: November 9, 1994
    Date of Patent: November 4, 1997
    Assignee: G. D. Searle & Co.
    Inventors: E. Ann Hallinan, Donald W. Hansen, Jr., Sofya Tsymbalov
  • Imidazo[1,2-a]pyridinylalkyl phosphonic acid compounds for treatment of neurotoxic injury
    Patent number: 5633237
    Abstract: A class of imidazo[1,2-a]pyridinylalkyl phosphonic acid compounds is described for treatment to reduce neurotoxic injury associated with anoxia or ischemia which typically follows stroke, cardiac arrest or perinatal asphyxia. The treatment includes administration of a compound of this class alone or in a composition in an amount effective as an antagonist to inhibit excitotoxic actions at major neuronal excitatory amino acid receptor sites. Compounds of most interest are those of the formula: ##STR1## and the carboxylic and phosphonic alkyl esters and salts thereof; wherein R.sup.9 is selected from hydrido, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl; wherein each of Y.sub.m and Y.sub.
    Type: Grant
    Filed: July 6, 1994
    Date of Patent: May 27, 1997
    Assignee: G.D. Searle & Co.
    Inventors: Donald W. Hansen, Jr., Gilbert W. Adelstein, Karen B. Peterson, Sofya Tsymbalov