Patents by Inventor Doris P. Schumacher

Doris P. Schumacher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of 2-Hydroxy-N,N-dimethyl-3-[[2-[[1(R)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide
    Patent number: 7910775
    Abstract: Disclosed is a process for making the compound of formula I: using the compounds of formulas II, Q, and XI or XII: wherein A is selected from the group consisting of Br, Cl and I (with Br being preferred); and R represents (C1-C10)alkyl. Also disclosed are intermediate compounds that are made in the disclosed process.
    Type: Grant
    Filed: October 17, 2008
    Date of Patent: March 22, 2011
    Assignee: Schering Corporation
    Inventors: Jianguo Yin, Xiaoyong Fu, Shuyi Zhang, Timothy L. McAllister, Agnes S. Kim-Meade, Jason L. Winters, Anantha Sudhakar, Doris P. Schumacher
  • SYNTHESIS OF 2-HYDROXY-N,N-DIMETHYL-3-[[2-[[1(R)-(5-METHYL-2-FURANYL)PROPYL]AMINO]-3,4-DIOXO-1-CYCLOBUTEN-1-YL]AMINO]BENZAMIDE
    Publication number: 20090048458
    Abstract: Disclosed is a process for making the compound of formula I: using the compounds of formulas II, Q, and XI or XII: wherein A is selected from the group consisting of Br, Cl and I (with Br being preferred); and R represents (C1-C10)alkyl. Also disclosed are intermediate compounds that are made in the disclosed process.
    Type: Application
    Filed: October 17, 2008
    Publication date: February 19, 2009
    Inventors: Jianguo Yin, Xiaoyong FU, Shuyi Zhang, Timothy L. McAllister, Agnes S. Kim-Meade, Jason L. Winters, Anantha Sudhakar, Doris P. Schumacher
  • Synthesis of 2-hydroxy-n,n-dimethyl-3-[[2-[[1(r)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide
    Patent number: 7462740
    Abstract: Disclosed is a process for making the compound of formula I: using the compounds of formulas II, Q, and XI or XII: wherein A is selected from the group consisting of Br, Cl and I (with Br being preferred); and R represents (C1-C10)alkyl. Also disclosed are intermediate compounds that are made in the disclosed process.
    Type: Grant
    Filed: May 9, 2006
    Date of Patent: December 9, 2008
    Assignee: Schering Corporation
    Inventors: Jianguo Yin, Xiaoyong Fu, Shuyi Zhang, Timothy L. McAllister, Agnes S. Kim-Meade, Jason L. Winters, Anantha Sudhakar, Doris P. Schumacher
  • Synthesis of 2-hydroxy-N,N-dimethyl-3-[ [2-[1 (R)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]aminobenzamide
    Patent number: 7071342
    Abstract: Disclosed is a process for making the compound of formula I: using the compounds of formulas II, Q, and XI or XII: wherein A is selected from the group consisting of Br, Cl and I (with Br being preferred); and R represents (C1–C10)alkyl. Also disclosed are intermediate compounds that are made in the disclosed process.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: July 4, 2006
    Assignee: Schering Corporation
    Inventors: Jianguo Yin, Xiaoyong Fu, Shuyi Zhang, Timothy L. McAllister, Agnes S. Kim-Meade, Jason L. Winters, Anantha Sudhakar, Doris P. Schumacher
  • Process for synthesis of D1 receptor antagonists
    Patent number: 6875866
    Abstract: In one embodiment, the present invention describes the synthesis of a compound of formula and intermediates therefor.
    Type: Grant
    Filed: February 19, 2003
    Date of Patent: April 5, 2005
    Assignee: Schering Corporation
    Inventors: Vilas H. Dahanukar, Jeffrey M. Eckert, Dinesh Gala, Brian Lucas, Doris P. Schumacher, Ilia Zavialov
  • Synthesis of 2-hydroxy-N,N-dimethyl-3-[[2-[1(R)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-l]aminobenzamide
    Publication number: 20040209946
    Abstract: Disclosed is a process for making the compound of formula I: 1
    Type: Application
    Filed: April 16, 2004
    Publication date: October 21, 2004
    Applicant: Schering Corporation
    Inventors: Jianguo Yin, Xiaoyong Fu, Shuyi Zhang, Timothy L. McAllister, Agnes S. Kim-Meade, Jason L. Winters, Anantha Sudhakar, Doris P. Schumacher
  • Process for synthesis of D1 receptor antagonists
    Publication number: 20030199690
    Abstract: In one embodiment, the present invention describes the synthesis of a compound of formula 1
    Type: Application
    Filed: February 19, 2003
    Publication date: October 23, 2003
    Applicant: Schering Corporation
    Inventors: Vilas H. Dahanukar, Jeffrey M. Eckert, Dinesh Gala, Brian Lucas, Doris P. Schumacher, Ilia Zavialov
  • 8-chloro-6,11-dihydro-11-(4-piperidylidine)-5H-benzo[5,6]cyclohepta[1-2-b] pyridine
    Patent number: 6506767
    Abstract: Crystalline polymorphs of 8-chloro-6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cycloheptic[1,2-b]pyridine represented by the formula pharmaceutical compositions containing such polymorphs, and methods of using such polymorphs to treat allergic reactions in mammals such as man are disclosed.
    Type: Grant
    Filed: July 1, 1998
    Date of Patent: January 14, 2003
    Assignee: Schering Corporation
    Inventors: Doris P. Schumacher, Junning Lee, Lawrence R. Rogers, Charles G. Eckhart, Naneshwar S. Sawant, Michael B. Mitchell
  • 3-hydroxy gamma-lactone based enantioselective synthesis of azetidinones
    Patent number: 6096883
    Abstract: The invention relates to intermediates of the formulae ##STR1## said intermediates being useful in a process for producing a compound of the formula ##STR2## wherein Bn is benzyl and R.sub.1, .sub.2 and R.sub.
    Type: Grant
    Filed: December 14, 1998
    Date of Patent: August 1, 2000
    Assignee: Schering Corporation
    Inventors: George G. Wu, Xing Chen, Yee-Shing Wong, Doris P. Schumacher, Martin Steinman
  • 3-hydroxy gamma-lactone based enantioselective synthesis of azetidinones
    Patent number: 5886171
    Abstract: The invention relates to a process for producing a compound of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.
    Type: Grant
    Filed: May 28, 1997
    Date of Patent: March 23, 1999
    Assignee: Schering Corporation
    Inventors: Guang-Zhong Wu, Xing Chen, Yee-Shing Wong, Doris P. Schumacher, Martin Steinman
  • 3-hydroxy .gamma.-lactone based enantionselective synthesis of azetidinones
    Patent number: 5739321
    Abstract: The invention relates to a process for producing the compound of the formula ##STR1## which comprises reacting lactone of formula II ##STR2## with an imine of formula III': ##STR3## and converting the resulting chiral diol of formula VI: ##STR4## through several steps to obtain a compound of formula I'.
    Type: Grant
    Filed: May 31, 1996
    Date of Patent: April 14, 1998
    Assignee: Schering Corporation
    Inventors: Guang-Zhong Wu, Xing Chen, Yee-Shing Wong, Doris P. Schumacher, Martin Steinman
  • Process for preparing florfenicol, its analogs and oxazoline intermediates thereto
    Patent number: 5382673
    Abstract: A process for preparing a compound of formula (IV): ##STR1## comprising a) contacting an oxazoline compound of formula (I): ##STR2## wherein Z is as defined hereinbefore, with a reagent capable of causing an equilibrium between oxazoline compound (I) and an oxazoline compound of formula (II) described herein, and the reagent drives the equilibrium toward oxazoline compound (II) by preferential precipitation of oxazoline compound (II);b) contacting compound (II) with a fluorinating agent to give a fluorinated oxazoline compound of formula (III) described herein; andc) hydrolyzing the compound of formula (III) to formula (IV). In an alternative embodiment, the process is directed toward a process for preparing oxazoline (II) in a single step.
    Type: Grant
    Filed: April 22, 1993
    Date of Patent: January 17, 1995
    Assignee: Schering Corporation
    Inventors: Jon E. Clark, Doris P. Schumacher, Guang-Zhong Wu
  • Process for preparing oxazoline compounds
    Patent number: 5227494
    Abstract: A novel process for regioselectively preparing oxazoline compounds is disclosed. The process utilizes an amino alcohol, a cyano compound, a base and a dihydric alcohol solvent, a polyhydric alcohol solvent or mixtures thereof.
    Type: Grant
    Filed: June 29, 1992
    Date of Patent: July 13, 1993
    Assignee: Schering Corporation
    Inventors: Doris P. Schumacher, Jon E. Clark, Bruce L. Murphy
  • Pressurized fluorination of hydroxy alkyl groups
    Patent number: 4876352
    Abstract: There is disclosed a high yielding process for converting a hydroxy alkyl oxazolidine compound to the corresponding fluoro derivative by reacting the hydroxy compound with .alpha., .alpha.-difluoroalkylamine under pressure.
    Type: Grant
    Filed: September 14, 1988
    Date of Patent: October 24, 1989
    Assignee: Schering Corporation
    Inventors: Doris P. Schumacher, Jon E. Clark, Bruce L. Murphy
  • 3-phenethyl-2-benzene-amides or aza-derivatives thereof
    Patent number: 4873335
    Abstract: Compounds of the formula: ##STR1## are produced, with the variables as indicated within.
    Type: Grant
    Filed: December 2, 1987
    Date of Patent: October 10, 1989
    Assignee: Schering Corporation
    Inventors: Doris P. Schumacher, Bruce L. Murphy, Jon E. Clark
  • Antihistaminic fluoro substituted benzocycloheptapyridines
    Patent number: 4863931
    Abstract: Certain benzocycloheptapyridine compounds with fluorine substitution across the exocyclic double bond are prepared and they are useful as antihistaminic agents.
    Type: Grant
    Filed: September 15, 1988
    Date of Patent: September 5, 1989
    Assignee: Schering Corporation
    Inventors: Doris P. Schumacher, Bruce L. Murphy, Jon E. Clark
  • Conversion of aristeromycin into cyclaradine
    Patent number: 4740598
    Abstract: A process for the conversion of aristeromycin into cyclaradine via. The stereoselective reduction of a 3',5'-di-O-protected-2'-keto derivative of aristeromycin is disclosed.
    Type: Grant
    Filed: May 20, 1986
    Date of Patent: April 26, 1988
    Assignee: Schering Corporation
    Inventors: Tattanahali L. Nagabhushan, Doris P. Schumacher
  • Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof
    Patent number: 4731447
    Abstract: A process for the preparation of piperidylidene-dihydro-dibenzo[a,d]cycloheptene or aza-derivatives thereof and intermediates in such process are disclosed.
    Type: Grant
    Filed: March 12, 1986
    Date of Patent: March 15, 1988
    Assignee: Schering Corporation
    Inventors: Doris P. Schumacher, Bruce L. Murphy, Jon E. Clark
  • Derivatives of antibiotic AR-5 components
    Patent number: 4366309
    Abstract: Novel macrolide antibacterial derivatives of the components of the Antibiotic AR-5-complex are disclosed herein. The invention specifically relates to compounds wherein the macrolide ring and/or the two attached sugars are derivatized. Also disclosed are methods for the preparation of the derivatives and methods for the use thereof.
    Type: Grant
    Filed: April 13, 1981
    Date of Patent: December 28, 1982
    Assignee: Schering Corporation
    Inventors: Ashit K. Ganguly, Yi-Tsung Liu, Olga Sarre, Robert Jaret, Doris P. Schumacher