Patents by Inventor Dorte Buchardt

Dorte Buchardt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of nucleic acid analogues in the inhibition of nucleic acid amplification
    Patent number: 5972610
    Abstract: The present invention relates to the use of nucleic acid analogues in blocking nucleic acid amplification procedures and to diagnostic and analytical techniques based thereon. Also included are kits for use in the conduct of nucleic acid amplification reactions.
    Type: Grant
    Filed: October 8, 1997
    Date of Patent: October 26, 1999
    Inventors: Ole Buchardt, deceased, by Dorte Buchardt, legal representative, Michael Egholm, Peter Eigil Nielsen, Rolf Henrik Berg, Christopher John Stanley
  • Peptide nucleic acids having amino acid side chains
    Patent number: 5786461
    Abstract: A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than the corresponding DNA or RNA strands, and exhibit increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone, and contain alkylamine side chains.
    Type: Grant
    Filed: May 1, 1997
    Date of Patent: July 28, 1998
    Inventors: Ole Buchardt, deceased, Michael Egholm, Peter Eigil Nielsen, Rolf Henrik Berg, Dorte Buchardt
  • Peptide nucleic acids having enhanced binding affinity and sequence specificity
    Patent number: 5766855
    Abstract: A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and binding affinity. Methods of increasing binding affinity and sequence specificity of peptide nucleic acids are provided wherein some peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone, while other peptide nucleic acids contain at least one 2,6-diaminopurine nucleobase and at least one C.sub.1 -C.sub.8 alkylamine side chain.
    Type: Grant
    Filed: July 24, 1996
    Date of Patent: June 16, 1998
    Inventors: Ole Buchardt, deceased, Michael Egholm, Peter Eigil Nielsen, Rolf Henrik Berg, by Dorte Buchardt, executor
  • Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
    Patent number: 5736336
    Abstract: A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone, and contain C.sub.1 -C.sub.8 alkylamine side chains. Methods of enhancing the solubility, binding affinity and sequence specificity of PNAs are provided.
    Type: Grant
    Filed: May 1, 1997
    Date of Patent: April 7, 1998
    Inventors: Ole Buchardt, deceased, by Dorte Buchardt, representative, Michael Egholm, Peter Eigil Nielsen, Rolf Henrik Berg
  • Peptide nucleic acids having amino acid side chains
    Patent number: 5719262
    Abstract: A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than the corresponding DNA or RNA strands, and exhibit increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone, and contain alkylamine side chains.
    Type: Grant
    Filed: July 24, 1996
    Date of Patent: February 17, 1998
    Inventors: Ole Buchardt, deceased, by Dorte Buchardt, legal representative, Michael Egholm, Peter Eigil Nielsen, Rolf Henrik Berg
  • Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
    Patent number: 5714331
    Abstract: A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than a corresponding DNA strand, and exhibit increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone, and contain C.sub.1 -C.sub.8 alkylamine side chains. Methods of enhancing the solubility, binding affinity and sequence specificity of PNAs are provided.
    Type: Grant
    Filed: July 24, 1996
    Date of Patent: February 3, 1998
    Inventors: Ole Buchardt, deceased, by Dorte Buchardt, representative, Michael Egholm, Peter Eigil Nielsen, Rolf Henrik Berg