Patents by Inventor Doug Marchuk

Doug Marchuk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for treating vascular malformation and related conditions
    Patent number: 11452737
    Abstract: In one aspect, the present invention features a method of inhibiting proliferation and/or reducing survival of a cell comprising a GNAQ polynucleotide or polypeptide having a R183Q or Q209L mutation, comprising contacting the cell with puromycin or a puromycin analog, thereby inhibiting proliferation and/or reducing survival of the cell. In another aspect, a method of treating a vascular malformation or related condition in a subject, comprising administering to the subject an effective amount of puromycin or a puromycin analog is featured.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: September 27, 2022
    Assignees: The Johns Hopkins University, Duke University, Kennedy Krieger Institute, Inc.
    Inventors: Anne Comi, Jonathan Pevsner, Zhenhua Huang, Doug Marchuk
  • COMPOSITIONS AND METHODS FOR TREATING VASCULAR MALFORMATION AND RELATED CONDITIONS
    Publication number: 20180235994
    Abstract: In one aspect, the present invention features a method of inhibiting proliferation and/or reducing survival of a cell comprising a GNAQ polynucleotide or polypeptide having a R183Q or Q209L mutation, comprising contacting the cell with puromycin or a puromycin analog, thereby inhibiting proliferation and/or reducing survival of the cell. In another aspect, a method of treating a vascular malformation or related condition in a subject, comprising administering to the subject an effective amount of puromycin or a puromycin analog is featured.
    Type: Application
    Filed: July 28, 2016
    Publication date: August 23, 2018
    Inventors: Anne Comi, Jonathan Pevsner, Zhenhua Huang, Doug Marchuk