Patents by Inventor Douglas A. Julin

Douglas A. Julin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Translationally-coupled reporter gene
    Patent number: 6391641
    Abstract: A method of selecting for missense mutants that express a protein is disclosed. The method comprises constructing an operon comprising an upstream gene and a downstream reporter gene, wherein the upstream gene and the reporter gene are translationally coupled, wherein the reporter protein is expressed after the translation of the upstream gene. The method further comprises expressing the downstream reporter gene after introducing at least one mutation into the upstream gene. Finally, the mutants are screened for the ability to express the reporter protein, which is indicative of a missense mutant.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: May 21, 2002
    Assignee: University of Maryland, College Park
    Inventors: Douglas A. Julin, Jingdi Wang, Ruiwu Wang