Patents by Inventor Douglas B. Dority
Douglas B. Dority has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11927600Abstract: A fluidic bridge device for transport of a fluid sample between a first sample processing device and a second sample processing device. The fluidic bridge may include one or more fluid channels extending between fluid-tight couplings attachable to transfer ports of the first and second sample processing device. In one aspect the first device is a sample preparation device and the second device is an assay device. The fluidic bridge can include at least two fluid conduits, at least one for transport of the prepared sample, and at least one other to facilitate displacement of air to allow flow of the prepared sample through the other fluid conduit. The fluid channels can include one or more of an amplification chamber, a processing chamber, a gas-permeable vent, a bubble trap, a filter, and an external port. Methods of preparing and transporting a fluid sample between devices are provided herein.Type: GrantFiled: September 28, 2017Date of Patent: March 12, 2024Assignee: CepheidInventor: Douglas B. Dority
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Publication number: 20240027487Abstract: Systems for processing a fluid sample to facilitate analysis with a semiconductor detection chip are provided herein. Such systems can include a sample processing cartridge coupleable with a chip carrier device configured for transport of the processed fluid sample from the sample cartridge. The chip carrier device can include one or more fluid channels extending between fluid-tight couplings attachable to transfer ports of the sample processing cartridge. The chip carrier device can include multiple portions or adapters, including a fluid sample portion, a flowcell portion and a chip carrier. Also provided are methods of preparing and transporting a fluid sample from a sample cartridge into a chip carrier device for analysis with a semiconductor detection chip carried within the chip carrier device.Type: ApplicationFiled: July 25, 2023Publication date: January 25, 2024Inventors: Douglas B. Dority, Jonathan Siegrist, Ronald Chang
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Publication number: 20230330666Abstract: Diagnostic detection chip device designs that reduce cost of fabrication and assembly are described herein. Such chip device designs include features that facilitate use of the chip within a chip carrier device with integrated fluid flow control features and compatibility with conventional sample cartridges and sample processing systems. Associated methods of manufacture and assembly of the chip devices are also provided herein.Type: ApplicationFiled: March 17, 2023Publication date: October 19, 2023Inventor: Douglas B. Dority
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Publication number: 20230330665Abstract: Improved sample cartridges, valve assemblies and methods of manufacture and assembly are provided herein. Such systems can include a sample processing cartridge having a unitary cartridge body with integral syringe tube and valve interface. Such systems can further includes valve assemblies with an overmolded gasket and gaskets with a protruding conical valve sealing surface. Various additional features can include thin film sealing for cartridge as well as valve assemblies for chemical lysis. Thin film sealing for cartridge lids can include various multi-layered designs to facilitate injection and sealing of reagents within the cartridge. Magnetic separation features are also included. Such features can be included in various design iterations as needed for compatibility with existing technologies and to accommodate needs for manufacturing workflows.Type: ApplicationFiled: March 15, 2023Publication date: October 19, 2023Inventors: Douglas B. Dority, Alan E. Tucker
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Patent number: 11740256Abstract: Systems for processing a fluid sample to facilitate analysis with a semiconductor detection chip are provided herein. Such systems can include a sample processing cartridge coupleable with a chip carrier device configured for transport of the processed fluid sample from the sample cartridge. The chip carrier device can include one or more fluid channels extending between fluid-tight couplings attachable to transfer ports of the sample processing cartridge. The chip carrier device can include multiple portions or adapters, including a fluid sample portion, a flowcell portion and a chip carrier. Also provided are methods of preparing and transporting a fluid sample from a sample cartridge into a chip carrier device for analysis with a semiconductor detection chip carried within the chip carrier device.Type: GrantFiled: September 20, 2019Date of Patent: August 29, 2023Assignee: CepheidInventors: Douglas B Dority, Jonathan Siegrist, Ronald Chang
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Publication number: 20230166263Abstract: Improved sub-assemblies and methods of control for use in a diagnostic assay system adapted to receive an assay cartridge are provided herein. Such sub-assemblies include: a brushless DC motor, a door opening/closing mechanism and cartridge loading mechanism, a syringe and valve drive mechanism assembly, a sonication horn, a thermal control device and optical detection/excitation device. Such systems can further include a communications unit configured to wirelessly communicate with a mobile device of a user so as to receive a user input relating to functionality of the system with respect to an assay cartridge received therein and relaying a diagnostic result relating to the assay cartridge to the mobile device.Type: ApplicationFiled: November 11, 2022Publication date: June 1, 2023Inventors: Douglas B. Dority, Tien Phan, David Fromm, Richard J. Casler, JR., Dustin Dickens, Stuart Morita, Matthew Piccini
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Patent number: 11628435Abstract: Diagnostic detection chip device designs that reduce cost of fabrication and assembly are described herein. Such chip device designs include features that facilitate use of the chip within a chip carrier device with integrated fluid flow control features and compatibility with conventional sample cartridges and sample processing systems. Associated methods of manufacture and assembly of the chip devices are also provided herein.Type: GrantFiled: December 13, 2019Date of Patent: April 18, 2023Assignee: CepheidInventor: Douglas B. Dority
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Patent number: 11524301Abstract: Improved sub-assemblies and methods of control for use in a diagnostic assay system adapted to receive an assay cartridge are provided herein. Such sub-assemblies include: a brushless DC motor, a door opening/closing mechanism and cartridge loading mechanism, a syringe and valve drive mechanism assembly, a sonication horn, a thermal control device and optical detection/excitation device. Such systems can further include a communications unit configured to wirelessly communicate with a mobile device of a user so as to receive a user input relating to functionality of the system with respect to an assay cartridge received therein and relaying a diagnostic result relating to the assay cartridge to the mobile device.Type: GrantFiled: January 9, 2020Date of Patent: December 13, 2022Assignee: CepheidInventors: Douglas B Dority, Tien Phan, David Fromm, Richard J. Casler, Jr., Dustin Dickens, Stuart Morita, Matthew Piccini
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Publication number: 20210187505Abstract: A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least one external port. The fluid displacement region is fluidicly coupled with at least one external port of the body. The body is adjustable with respect to the plurality of chambers to place the at least one external port selectively in fluidic communication with the plurality of chambers.Type: ApplicationFiled: December 23, 2020Publication date: June 24, 2021Inventors: Douglas B. Dority, Ronald Chang
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Patent number: 10906039Abstract: A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least one external port. The fluid displacement region is fluidicly coupled with at least one external port of the body. The body is adjustable with respect to the plurality of chambers to place the at least one external port selectively in fluidic communication with the plurality of chambers.Type: GrantFiled: December 5, 2019Date of Patent: February 2, 2021Assignee: CepheidInventors: Douglas B. Dority, Ronald Chang
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Patent number: 10767226Abstract: A honeycomb tube with a planar frame defining a fluidic path between a first planar surface and a second planar surface. A fluidic interface is located at one end of the planar frame. The fluidic interface has a fluidic inlet and fluidic outlet. The fluidic path further includes a well chamber having an well-substrate with a plurality of wells. The well chamber is arranged in the planar frame between the first or second surface and the well-substrate.Type: GrantFiled: December 21, 2018Date of Patent: September 8, 2020Assignee: CepheidInventors: Yuh-Min Chiang, Douglas B Dority, Dustin Dickens, Jennifer Glass, Reuel Van Atta
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Publication number: 20200254451Abstract: Diagnostic detection chip device designs that reduce cost of fabrication and assembly are described herein. Such chip device designs include features that facilitate use of the chip within a chip carrier device with integrated fluid flow control features and compatibility with conventional sample cartridges and sample processing systems. Associated methods of manufacture and assembly of the chip devices are also provided herein.Type: ApplicationFiled: December 13, 2019Publication date: August 13, 2020Inventor: Douglas B. Dority
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Publication number: 20200188922Abstract: Improved sub-assemblies and methods of control for use in a diagnostic assay system adapted to receive an assay cartridge are provided herein. Such sub-assemblies include: a brushless DC motor, a door opening/closing mechanism and cartridge loading mechanism, a syringe and valve drive mechanism assembly, a sonication horn, a thermal control device and optical detection/excitation device. Such systems can further include a communications unit configured to wirelessly communicate with a mobile device of a user so as to receive a user input relating to functionality of the system with respect to an assay cartridge received therein and relaying a diagnostic result relating to the assay cartridge to the mobile device.Type: ApplicationFiled: January 9, 2020Publication date: June 18, 2020Inventors: Douglas B. Dority, Tien Phan, David Fromm, Rick Casler, Dustin Dickens, Stuart Morita, Matthew Piccini
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Publication number: 20200156067Abstract: A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least one external port. The fluid displacement region is fluidicly coupled with at least one external port of the body. The body is adjustable with respect to the plurality of chambers to place the at least one external port selectively in fluidic communication with the plurality of chambers.Type: ApplicationFiled: December 5, 2019Publication date: May 21, 2020Inventors: Douglas B. Dority, Ronald Chang
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Publication number: 20200116750Abstract: Systems for processing a fluid sample to facilitate analysis with a semiconductor detection chip are provided herein. Such systems can include a sample processing cartridge coupleable with a chip carrier device configured for transport of the processed fluid sample from the sample cartridge. The chip carrier device can include one or more fluid channels extending between fluid-tight couplings attachable to transfer ports of the sample processing cartridge. The chip carrier device can include multiple portions or adapters, including a fluid sample portion, a flowcell portion and a chip carrier. Also provided are methods of preparing and transporting a fluid sample from a sample cartridge into a chip carrier device for analysis with a semiconductor detection chip carried within the chip carrier device.Type: ApplicationFiled: September 20, 2019Publication date: April 16, 2020Inventors: DOUGLAS B. DORITY, Jonathan Siegrist, Ronald Chang
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Patent number: 10525468Abstract: A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least one external port. The fluid displacement region is fluidicly coupled with at least one external port of the body. The body is adjustable with respect to the plurality of chambers to place the at least one external port selectively in fluidic communication with the plurality of chambers.Type: GrantFiled: May 22, 2017Date of Patent: January 7, 2020Assignee: CepheidInventors: Douglas B. Dority, Ronald Chang
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Publication number: 20190211396Abstract: A honeycomb tube with a planar frame defining a fluidic path between a first planar surface and a second planar surface. A fluidic interface is located at one end of the planar frame. The fluidic interface has a fluidic inlet and fluidic outlet. The fluidic path further includes a well chamber having an well-substrate with a plurality of wells. The well chamber is arranged in the planar frame between the first or second surface and the well-substrate.Type: ApplicationFiled: December 21, 2018Publication date: July 11, 2019Inventors: YUH-MIN CHIANG, Douglas B. Dority, Dustin Dickens, Jennifer Glass, Reuel Van Atta
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Patent number: 10247646Abstract: A self-contained biological sample processing cartridge includes top and bottom portions that close together to form a sealed chamber therein. The chamber is configured to enable one of one or more biological sample staining procedures appropriate for a biological sample. The top portion includes a chamber top section and valve control elements. The bottom portion includes a chamber bottom section and fluidic valves. One of the fluid valves evacuates the contents of the chamber. One of the valve control elements couples to a respective fluidic valve to control fluid flow for the chamber. The cartridge includes a preloaded reagent component to supply the chamber with the reagent component appropriate for a particular biological sample staining procedure. A user desiring to conduct a particular biological sample staining procedure may select a particular cartridge that is preloaded with the preloaded reagent fluidic valves component appropriate for the particular biological sample staining procedure.Type: GrantFiled: March 9, 2015Date of Patent: April 2, 2019Assignee: SYFR, INC.Inventors: Shazi S Iqbal, Steven M Montgomery, Ronald Chang, Gregory E Mote, Douglas B Dority, Jeffrey S Ross
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Publication number: 20180169659Abstract: A thermal cycling apparatus having a sample interfacing wall extending from a mounting wall. The sample interfacing wall can accept and apply thermal cycles to samples. An air source can direct an air stream to cool the sample. Another source can direct heated air away from the sample.Type: ApplicationFiled: February 2, 2018Publication date: June 21, 2018Inventor: Douglas B. Dority
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Publication number: 20180031592Abstract: A fluidic bridge device for transport of a fluid sample between a first sample processing device and a second sample processing device. The fluidic bridge may include one or more fluid channels extending between fluid-tight couplings attachable to transfer ports of the first and second sample processing device. In one aspect the first device is a sample preparation device and the second device is an assay device. The fluidic bridge can include at least two fluid conduits, at least one for transport of the prepared sample, and at least one other to facilitate displacement of air to allow flow of the prepared sample through the other fluid conduit. The fluid channels can include one or more of an amplification chamber, a processing chamber, a gas-permeable vent, a bubble trap, a filter, and an external port. Methods of preparing and transporting a fluid sample between devices are provided herein.Type: ApplicationFiled: September 28, 2017Publication date: February 1, 2018Inventor: Douglas B Dority