Patents by Inventor Douglas B. Johnson

Douglas B. Johnson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190284640
    Abstract: The presently-disclosed subject matter relates to methods and systems for examining tumor samples, methods and systems for identifying subjects who are likely responders to treatment, and methods for treating cancer. In some embodiments, the presently-disclosed subject matter relates to determining expression of a major histocompatibility complex-II (MHC-II) molecule on a cell from a tumor sample, and further involving determining presence of tumor-infiltrating T cells in the tumor sample, determining the presence of tumor-infiltrating lymphocytes in the tumor sample, detecting chemokine expression in the tumor sample, and/or detecting TP53 mutations in the tumor sample. In some embodiments, the method involves treatment with an immunotherapeutic agent either alone or in combination with an MDM2 antagonist or an MEK inhibitor.
    Type: Application
    Filed: March 15, 2019
    Publication date: September 19, 2019
    Inventors: Justin M. Balko, Douglas B. Johnson, Violeta Sanchez de Delgado, Melinda Sanders
  • Publication number: 20190031420
    Abstract: Dual sealing caps enclose, for example, a series of liquids to be combined to achieve desiderata of users. By providing, for example co-branded liquids such as an ethyl alcohol (Grey Goose® brand of vodka) and an energy drink (for example RGCKSTAR® brand or RED BULL® brand of energy drink), a fully loaded and pre-packaged bomb shot is offered for consideration according to the instant teachings. Likewise, modular and coaxial chamber sets that house substances to be at least temporarily separated are disclosed, taught (and available through Xtremco of Southern California) for housing of a multiplicity of substances, moieties and materials.
    Type: Application
    Filed: February 13, 2017
    Publication date: January 31, 2019
    Inventor: Douglas B Johnson
  • Publication number: 20180238904
    Abstract: The present disclosure relates generally to the analysis of immune checkpoint proteins involved in cancer. In particular, the present disclosure provides material and methods for determining abundance ratios of various immune checkpoint proteins (e.g., PD-1, PD-L1, and PD-L2) present in a biospecimen sample based on quantification of peak area using mass spectrometry analysis. The methods disclosed herein provide an alternative platform for diagnosing and treating cancer, especially in cases limited by ineffective antibody recognition.
    Type: Application
    Filed: February 20, 2018
    Publication date: August 23, 2018
    Inventors: Daniel C. Liebler, Lisa J. Zimmerman, Hyoungjoo Lee, Carlos A. Morales Betanzos, Douglas B. Johnson
  • Publication number: 20170168054
    Abstract: A method of detecting cell membrane expression of an MHC molecule in a subject, a method of treating cancer in a subject with an immunotherapeutic agent, and an MHC complex are provided. The method of detecting cell membrane expression of an MHC molecule includes obtaining a tumor cell sample from a subject, and detecting cell membrane expression of the MHC molecule by contacting the tumor cell sample with an antibody targeting the MHC molecule and detecting binding between the MHC molecule and the antibody. The method of treating cancer in a subject with an immunotherapeutic agent includes detecting cell membrane expression of an MHC molecule in the subject and administering a therapeutically effective amount of the immunotherapeutic agent if the level of cell membrane expression of the MHC molecule exceeds a predetermined standard. The complex includes a tumor cell in complex with an antibody or an antigen-binding portion thereof.
    Type: Application
    Filed: December 12, 2016
    Publication date: June 15, 2017
    Inventors: Justin M. Balko, Douglas B. Johnson, Violeta Sanchez de Delgado, Melinda Sanders
  • Patent number: 8474635
    Abstract: An ultrasonic liquefaction endodontic system having a graspable hand piece includes a contra-angle tip assembly that has an insert and an internal fluid flow passageway. A portion of the fluid flow passageway passes through a C-shaped receiver located at the end of the receiver so that an ultrasonic frequency may pass directly to the fluid flowing through the passageway. The fluid flow passageway may be an injection tube and the tubular body portion of the tip assembly may be injection molded around the injection tube and the insert. A supply tube, which is held in position by tube guides connected to the hand piece, provides a source of flushing fluid with and without pulsed pressure. The fluid pressure pulses may have an ultrasonic energy superimposed thereon as the fluid is forced into a root canal.
    Type: Grant
    Filed: October 24, 2011
    Date of Patent: July 2, 2013
    Inventor: Douglas B. Johnson
  • Publication number: 20120040306
    Abstract: An ultrasonic liquefaction endodontic system having a graspable hand piece includes a contra-angle tip assembly that has an insert and an internal fluid flow passageway. A portion of the fluid flow passageway passes through a C-shaped receiver located at the end of the receiver so that an ultrasonic frequency may pass directly to the fluid flowing through the passageway. The fluid flow passageway may be an injection tube and the tubular body portion of the tip assembly may be injection molded around the injection tube and the insert. A supply tube, which is held in position by tube guides connected to the hand piece, provides a source of flushing fluid with and without pulsed pressure. The fluid pressure pulses may have an ultrasonic energy superimposed thereon as the fluid is forced into a root canal.
    Type: Application
    Filed: October 24, 2011
    Publication date: February 16, 2012
    Inventor: Douglas B. Johnson
  • Patent number: 8043088
    Abstract: An ultrasonic liquefaction endodontic system having a graspable hand piece includes a contra-angle tip assembly that has an insert and an internal fluid flow passageway. A portion of the fluid flow passageway passes through a C-shaped receiver located at the end of the receiver so that an ultrasonic frequency may pass directly to the fluid flowing through the passageway. The fluid flow passageway may be an injection tube and the tubular body portion of the tip assembly may be injection molded around the injection tube and the insert. A supply tube, which is held in position by tube guides connected to the hand piece, provides a source of flushing fluid with and without pulsed pressure. The fluid pressure pulses may have an ultrasonic energy superimposed thereon as the fluid is forced into a root canal.
    Type: Grant
    Filed: October 21, 2008
    Date of Patent: October 25, 2011
    Inventor: Douglas B. Johnson
  • Publication number: 20090042163
    Abstract: An ultrasonic liquefaction endodontic system having a graspable hand piece includes a contra-angle tip assembly that has an insert and an internal fluid flow passageway. A portion of the fluid flow passageway passes through a C-shaped receiver located at the end of the receiver so that an ultrasonic frequency may pass directly to the fluid flowing through the passageway. The fluid flow passageway may be an injection tube and the tubular body portion of the tip assembly may be injection molded around the injection tube and the insert. A supply tube, which is held in position by tube guides connected to the hand piece, provides a source of flushing fluid with and without pulsed pressure. The fluid pressure pulses may have an ultrasonic energy superimposed thereon as the fluid is forced into a root canal.
    Type: Application
    Filed: October 21, 2008
    Publication date: February 12, 2009
    Inventor: Douglas B. Johnson
  • Patent number: 5622895
    Abstract: Multilayer circuit devices include a plurality of metallized patterns thereon, said patterns being separated by a polymeric dielectric film. The various metallized patterns are interconnected by means of microvias through the polymeric film or films. Each of the metallizations is a composite including in succession from the substrate or from the polymeric film, a layer of titanium (Ti), a layer of titanium and palladium alloy (Ti/Pd), a layer of copper (Cu), and a layer of titanium and palladium alloy (Ti/Pd). The Ti-Ti/Pd-Cu-Ti/Pd composite is hereinafter referred to as TCT. The adhesion between the polymeric film and the top Ti/Pd layer is better than that between the polymer and gold (Au) and comparable to that between the polymer and an adhesion promoted Au layer. Use of the TCT metallization also results in additional cost reduction due to the elimination of Ni and Au layers on top of the Cu layer.
    Type: Grant
    Filed: August 4, 1995
    Date of Patent: April 22, 1997
    Assignee: Lucent Technologies Inc.
    Inventors: Aaron L. Frank, Ajibola O. Ibidunni, Douglas B. Johnson, Dennis L. Krause, Trac Nguyen
  • Patent number: 5466972
    Abstract: Multilayer circuit devices include a plurality of metallized patterns thereon, said patterns being separated by a polymeric dielectric film. The various metallized patterns are interconnected by means of microvias through the polymeric film or films. Each of the metallizations is a composite including in succession from the substrate or from the polymeric film, a layer of titanium (Ti), a layer of titanium and palladium alloy (Ti/Pd), a layer of copper (Cu), and a layer of titanium and palladium alloy (Ti/Pd). The Ti--Ti/Pd--Cu--Ti/Pd composite is hereinafter referred to as TCT. The adhesion between the polymeric film and the top Ti/Pd layer is better than that between the polymer and gold (Au) and comparable to that between the polymer and an adhesion promoted Au layer. Use of the TCT metallization also results in additional cost reduction due to the elimination of Ni and Au layers on top of the Cu layer.
    Type: Grant
    Filed: May 9, 1994
    Date of Patent: November 14, 1995
    Assignee: AT&T Corp.
    Inventors: Aaron L. Frank, Ajibola O. Ibidunni, Douglas B. Johnson, Dennis L. Krause, Trac Nguyen