Patents by Inventor Douglas J. Koebler

Douglas J. Koebler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10983056
    Abstract: Embodiments of a cell culture monitoring system are disclosed that may include a device having collimating and filtering components to elicit and detect fluorescence from a substrate located within a reaction vessel. The device may be used to detect changes in pH and dissolved oxygen levels in a liquid contained in the reaction vessel due to growth of living cells. Excitation light beams can be generated and collimated by a beam combiner and directed into the reaction vessel so as to be incident upon the substrate to cause the substrate to fluoresce. Some embodiments include use of expected wavelength offsets and shifted filters/mirrors to improve functionality and reduce space of device components.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: April 20, 2021
    Assignee: Scientific Industries, Inc.
    Inventors: Michael Tolosa, William Chandler, Douglas J. Koebler, Joseph G. Cremonese, Brookman P. March
  • Publication number: 20190250103
    Abstract: Embodiments of a cell culture monitoring system are disclosed that may include a device having collimating and filtering components to elicit and detect fluorescence from a substrate located within a reaction vessel. The device may be used to detect changes in pH and dissolved oxygen levels in a liquid contained in the reaction vessel due to growth of living cells. Excitation light beams can be generated and collimated by a beam combiner and directed into the reaction vessel so as to be incident upon the substrate to cause the substrate to fluoresce. Some embodiments include use of expected wavelength offsets and shifted filters/mirrors to improve functionality and reduce space of device components.
    Type: Application
    Filed: April 26, 2019
    Publication date: August 15, 2019
    Inventors: Michael Tolosa, William Chandler, Douglas J. Koebler, Joseph G. Cremonese, Brookman P. March
  • Patent number: 10379047
    Abstract: Embodiments of a cell culture monitoring system are disclosed that may include a device having collimating and filtering components to elicit and detect fluorescence from a substrate located within a reaction vessel. The device may be used to detect changes in pH and dissolved oxygen levels in a liquid contained in the reaction vessel due to growth of living cells. Excitation light beams can be generated and collimated by a beam combiner and directed into the reaction vessel so as to be incident upon the substrate to cause the substrate to fluoresce. Some embodiments include use of expected wavelength offsets and shifted filters/mirrors to improve functionality and reduce space of device components.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: August 13, 2019
    Assignee: Scientific Industries, Inc.
    Inventors: Michael Tolosa, William Chandler, Douglas J. Koebler, Joseph G. Cremonese, Brookman P. March
  • Publication number: 20180149593
    Abstract: Embodiments of a cell culture monitoring system are disclosed that may include a device having collimating and filtering components to elicit and detect fluorescence from a substrate located within a reaction vessel. The device may be used to detect changes in pH and dissolved oxygen levels in a liquid contained in the reaction vessel due to growth of living cells. Excitation light beams can be generated and collimated by a beam combiner and directed into the reaction vessel so as to be incident upon the substrate to cause the substrate to fluoresce. Some embodiments include use of expected wavelength offsets and shifted filters/mirrors to improve functionality and reduce space of device components.
    Type: Application
    Filed: November 30, 2016
    Publication date: May 31, 2018
    Inventors: Yordan Kostov, Michael Tolosa, William Chandler, Douglas J. Koebler, Joseph G. Cremonese, Brookman P. March
  • Patent number: 9387284
    Abstract: A system for assisting blood flow in a patient includes an implantable pump system for assisting in blood flow from the heart and an implantable control system for communicative connection with the implantable pump system. The control system includes a pacemaker system that is operative to control heart rate and the pump system interdependently to achieve a determined level of blood flow assist. The control system is adapted to increase the heart rate of the patient to above a normal heart rate for the patient under the present conditions of the patient via the pacemaker while controlling the pump system to achieve the determined level of blood flow assist based upon the increased heart rate and a level of assist provided by the pump system.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: July 12, 2016
    Assignee: VASCOR, INC
    Inventors: Marlin Stephen Heilman, Douglas J. Koebler, Charles Robert Kohler, Jon David Wagner, David M. Reilly
  • Patent number: 9069175
    Abstract: An optical microscope is provided with an adjustable optical phase ring. The adjustable ring provides a way to compensate for distortion in the visible phase ring before the light reaches the sample. In an inverted microscope, when observing transparent cells under a liquid, the visible light phase ring is distorted. By the use of a Liquid Crystal Display (LCD) in place of a fixed ring, the projected ring is adjusted to realign the light and produce phase. In a typical micro plate, the meniscus formed produces a lens effect that is realigned by providing changes in the position and pattern, to allow phase imaging over a wider portion of the well. The realignment of the ring can be manual or automated and can be dynamically adjusted based upon an observed image of the sample.
    Type: Grant
    Filed: April 9, 2012
    Date of Patent: June 30, 2015
    Assignee: Kairos Instruments, LLC
    Inventors: Douglas J. Koebler, Alfred Blalock Bahnson
  • Publication number: 20150038772
    Abstract: A system for assisting blood flow in a patient includes an implantable pump system for assisting in blood flow from the heart and an implantable control system for communicative connection with the implantable pump system. The control system includes a pacemaker system that is operative to control heart rate and the pump system interdependently to achieve a determined level of blood flow assist. The control system is adapted to increase the heart rate of the patient to above a normal heart rate for the patient under the present conditions of the patient via the pacemaker while controlling the pump system to achieve the determined level of blood flow assist based upon the increased heart rate and a level of assist provided by the pump system.
    Type: Application
    Filed: October 21, 2014
    Publication date: February 5, 2015
    Inventors: MARLIN STEPHEN HEILMAN, DOUGLAS J. KOEBLER, CHARLES ROBERT KOHLER, JON DAVID WAGNER, DAVID M. REILLY
  • Patent number: 8876686
    Abstract: In one aspect, an implantable pump system for assisting blood flow in a patient includes a blood flow path comprising a flexible conduit, at least one valve in fluid connection with the flexible conduit, a drive system in operative connection with the valve to move the valve in a reciprocating manner, an implantable control system and at least one sensor in communicative connection with the control system. The sensor is adapted to measure at least one property of blood. The control system is adapted to control movement of the valve on the basis of data regarding position of the valve with respect to time or a derivative thereof (that is, position, velocity, acceleration or a derivative thereof) in combination with data of the measured at least one property of blood from the sensor.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: November 4, 2014
    Assignee: Vascor, Inc
    Inventors: Marlin Stephen Heilman, Douglas J. Koebler, Charles Robert Kohler, Jon David Wagner, David M. Reilly
  • Publication number: 20130041203
    Abstract: An implantable pump system for assisting blood flow includes a flexible conduit, at least one movable valve in fluid connection with the flexible conduit, a drive system comprising a rotary motor and a speed reducer operatively connected to the rotary motor; and a converter operatively connected to the drive system and operatively connected to the valve to drive the valve in a reciprocating linear manner. In a number of embodiments, the speed reducer includes a spur gear driving a ring gear, wherein the converter is operatively connected to the speed reducer.
    Type: Application
    Filed: February 9, 2012
    Publication date: February 14, 2013
    Inventors: MARLIN STEPHEN HEILMAN, DOUGLAS J. KOEBLER, CHARLES ROBERT KOHLER, JON DAVID WAGNER, DAVID M. REILLY
  • Publication number: 20130041204
    Abstract: In one aspect, an implantable pump system for assisting blood flow in a patient includes a blood flow path comprising a flexible conduit, at least one valve in fluid connection with the flexible conduit, a drive system in operative connection with the valve to move the valve in a reciprocating manner, an implantable control system and at least one sensor in communicative connection with the control system. The sensor is adapted to measure at least one property of blood. The control system is adapted to control movement of the valve on the basis of data regarding position of the valve with respect to time or a derivative thereof (that is, position, velocity, acceleration or a derivative thereof) in combination with data of the measured at least one property of blood from the sensor.
    Type: Application
    Filed: February 9, 2012
    Publication date: February 14, 2013
    Inventors: MARLIN STEPHEN HEILMAN, DOUGLAS J. KOEBLER, CHARLES ROBERT KOHLER, JON DAVID WAGNER, DAVID M. REILLY
  • Publication number: 20130041460
    Abstract: An implantable pump system for assisting blood flow includes a conduit adapted to be placed in fluid connection with a blood vessel and at least one movable valve in fluid connection with the conduit. The valve includes at least one closure member in operative connection with an opening therein. The pump system further includes and an activating system adapted to actively move the closure member toward at least one of a closed position or an open position and a drive system to move the valve. The closure member can, for example, be biased toward an open position.
    Type: Application
    Filed: February 9, 2012
    Publication date: February 14, 2013
    Inventors: MARLIN STEPHEN HEILMAN, DOUGLAS J. KOEBLER, CHARLES ROBERT KOHLER, JON DAVID WAGNER, DAVID M. REILLY
  • Publication number: 20120257040
    Abstract: An optical microscope is provided with an adjustable optical phase ring. The adjustable ring provides a way to compensate for distortion in the visible phase ring before the light reaches the sample. In an inverted microscope, when observing transparent cells under a liquid, the visible light phase ring is distorted. By the use of a Liquid Crystal Display (LCD) in place of a fixed ring, the projected ring is adjusted to realign the light and produce phase. In a typical micro plate, the meniscus formed produces a lens effect that is realigned by providing changes in the position and pattern, to allow phase imaging over a wider portion of the well. The realignment of the ring can be manual or automated and can be dynamically adjusted based upon an observed image of the sample.
    Type: Application
    Filed: April 9, 2012
    Publication date: October 11, 2012
    Applicant: KAIROS INSTRUMENTS, LLC
    Inventors: Douglas J. Koebler, Alfred Blalock Bahnson
  • Patent number: 7588530
    Abstract: A pump includes a flexible conduit, at least one valve attached to the flexible conduit about the perimeter of the valve; and a drive mechanism to move the valve to pump blood within the conduit. The drive mechanism can, for example, be adapted to complete a single stroke during each heart ventricle contraction and/or to complete multiple strokes (that is, oscillate) during a single contraction. The moveable valve includes a plurality of openings. Each of the plurality of openings has a closure mechanism in operative connection therewith which is operable to at least partially close the opening to which it is operatively connected when the moveable valve is moved forward and to open the opening to which it is operatively connected when the valve is moved rearward. In one embodiment, each closure mechanism includes a flap of resilient material.
    Type: Grant
    Filed: July 19, 2005
    Date of Patent: September 15, 2009
    Inventors: Marlin Stephen Heilman, Douglas J. Koebler, Daniel R. Moore, Edward K. Prem
  • Patent number: 6830931
    Abstract: An apparatus for monitoring proteins and cells. The apparatus includes a plate having wells in which cells are disposed. The apparatus includes means for analyzing the effect or proteins and other biological and chemical moieties on the cells. A method for monitoring of proteins and cells. A method for analyzing a cells. An apparatus for aligning light in a well of a plate for holding cells. A method for lighting a well. A method for determining a condition of a cell. An apparatus for indicating a condition of a cell. A method for establishing a focus profile of a plate having wells for holding cells. A method for manipulating cells. An apparatus for manipulating cells.
    Type: Grant
    Filed: October 26, 2001
    Date of Patent: December 14, 2004
    Assignee: Automated Cell, Inc.
    Inventors: Alfred Blalock Bahnson, Douglas J. Koebler, Charalambos N. Arthanassiou, Raymond K. Houck, Kris Sachsenmeier, Lei Qian
  • Publication number: 20040128077
    Abstract: An apparatus for following cells includes an automated biochamber having a plate with at least one well in which cells are disposed in a controlled environment automatically maintained at desired conditions. The apparatus includes means for tracking individual cells in the well over time. A method for following cells includes the steps of instructing a camera by a computer to take a first image of a first well of a plate. There is the step of taking automatically with the camera the first image of the well at the instruction of the computer at a first-time. There is the step of identifying a first cell in the well with the computer. There is the step of instructing the camera by the computer to take a second image of the well. There is the step of taking automatically with the camera the second image of the well at the instruction of the computer at a second time. There is the step of linking the first cell in the first image to the first cell in the second image.
    Type: Application
    Filed: December 27, 2002
    Publication date: July 1, 2004
    Applicant: Automated Cell, Inc.
    Inventors: Douglas J. Koebler, Charalambos N. Athanassiou, Lei Qian, Aleksandr I. Lisovich
  • Publication number: 20030082818
    Abstract: An apparatus for monitoring proteins and cells. The apparatus includes a plate having wells in which cells are disposed. The apparatus includes means for analyzing the effect or proteins and other biological and chemical moieties on the cells. A method for monitoring of proteins and cells. A method for analyzing a cells. An apparatus for aligning light in a well of a plate for holding cells. A method for lighting a well. A method for determining a condition of a cell. An apparatus for indicating a condition of a cell. A method for establishing a focus profile of a plate having wells for holding cells. A method for manipulating cells. An apparatus for manipulating cells.
    Type: Application
    Filed: October 26, 2001
    Publication date: May 1, 2003
    Applicant: Automated Cell, Inc.
    Inventors: Alfred Blalock Bahnson, Douglas J. Koebler, Charalambos N. Athanassiou, Raymond K. Houck, Kris F. Sachsenmeier, Lei Qian
  • Patent number: 5954954
    Abstract: The present invention pertains to an apparatus for gathering analyte. The apparatus comprises a pumping mechanism for pumping solvent at supercritical pressure. The apparatus also comprises an extraction mechanism which receives a first sample and at least a second sample separate and distinct from the first sample and extract analyte from them essentially simultaneously. The extraction mechanism is connected to the pump mechanism to receive solvent at supercritical pressure for extracting the analyte from the samples. The apparatus additionally comprises a collection mechanism for collecting analyte from the solvent after the analyte has been extracted from the samples. The collection mechanism receives the supercritical solvent having the analyte extracted from the samples from the extraction mechanism. The present invention pertains to a method for extracting analyte. The method comprises the steps of pumping solvent at a supercritical pressure.
    Type: Grant
    Filed: June 20, 1997
    Date of Patent: September 21, 1999
    Assignee: Suprex Corporation
    Inventors: Raymond K. Houck, Douglas J. Koebler, Glen P. Williams, Joseph M. Levy, Victor G. Danielson
  • Patent number: 5866004
    Abstract: A supercritical fluid extraction (SFE) system. The SFE system includes a mechanism for providing supercritical fluid for extracting analyte from a sample. The SFE system also includes an extraction vessel and a mechanism for moving the extraction vessel into fluidic communication with the SFE system so that supercritical fluid can flow through the extraction vessel and extract analyte from the sample. Preferably, the SFE system is additionally comprised of a mechanism for holding a plurality of extraction vessels and an extraction chamber assembly. In this design, the moving mechanism selectively moves an extraction vessel from the holding mechanism into the extraction chamber in fluidic communication with the SFE system. Preferably, the SFE system further includes a computer for controlling the functions of the SFE system. The computer, for instance, could automatically and sequentially control the supercritical fluid extractions of the samples within the holding mechanism.
    Type: Grant
    Filed: September 8, 1995
    Date of Patent: February 2, 1999
    Assignee: Suprex Corporation
    Inventors: Raymond K. Houck, Douglas J. Koebler, Glen P. Williams, Kenneth J. Kato, Robert D. Parks, Paul A. Bauer, Jr.
  • Patent number: 5750029
    Abstract: The present invention pertains to an apparatus for gathering analyte. The apparatus comprises a pumping mechanism for pumping solvent at supercritical pressure. The apparatus also comprises an extraction mechanism which receives a first sample and at least a second sample separate and distinct from the first sample and extract analyte from them essentially simultaneously. The extraction mechanism is connected to the pump mechanism to receive solvent at supercritical pressure for extracting the analyte from the samples. The apparatus additionally comprises a collection mechanism for collecting analyte from the solvent after the analyte has been extracted from the samples. The collection mechanism receives the supercritical solvent having the analyte extracted from the samples from the extraction mechanism. The present invention pertains to a method for extracting analyte. The method comprises the steps of pumping solvent at a supercritical pressure.
    Type: Grant
    Filed: February 13, 1995
    Date of Patent: May 12, 1998
    Assignee: Suprex Corporation
    Inventors: Raymond K. Houck, Douglas J. Koebler, Glen P. Williams, Joseph M. Levy, Victor G. Danielson
  • Patent number: 5316262
    Abstract: The present invention is an apparatus for restricting the flow of fluid. The apparatus defines a tubular member having a channel. The tubular member has a first portion in which the channel has a first cross sectional area. There is also a second portion for restricting the flow of fluid defined by a reproducible deformity in the channel such that the channel has a second cross sectional area which is smaller than the first cross sectional area of the first portion. The tubular member further defines a third portion having a third cross sectional area which is greater than the second cross sectional area of the second portion. All of the cross sectional dimensions of the second and third portions are disposed within a cylindrical envelope having a diameter equal to the diameter of the first portion and extending therefrom. The tubular member is comprised of a material having sufficient rigidity to maintain a preferred reproducible permanent deformity in the channel.
    Type: Grant
    Filed: January 31, 1992
    Date of Patent: May 31, 1994
    Assignee: Suprex Corporation
    Inventor: Douglas J. Koebler