Patents by Inventor Douglas J. Sheffler

Douglas J. Sheffler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METABOTROPIC GLUTAMATE RECEPTOR NEGATIVE ALLOSTERIC MODULATORS (NAMS) AND USES THEREOF
    Publication number: 20230113588
    Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.
    Type: Application
    Filed: August 8, 2022
    Publication date: April 13, 2023
    Inventors: Nicholas David Peter COSFORD, Dhanya RAVEENDRA-PANICKAR, Douglas J. SHEFFLER, John Howard HUTCHINSON, Reto Andreas GADIENT
  • Metabotropic glutamate receptor negative allosteric modulators (NAMs) and uses thereof
    Patent number: 11447453
    Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.
    Type: Grant
    Filed: March 12, 2020
    Date of Patent: September 20, 2022
    Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    Inventors: Nicholas David Peter Cosford, Dhanya Raveendra-Panickar, Douglas J. Sheffler, John Howard Hutchinson, Reto Andreas Gadient
  • METABOTROPIC GLUTAMATE RECEPTOR NEGATIVE ALLOSTERIC MODULATORS (NAMS) AND USES THEREOF
    Publication number: 20200347021
    Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.
    Type: Application
    Filed: March 12, 2020
    Publication date: November 5, 2020
    Inventors: Nicholas David Peter COSFORD, Dhanya RAVEENDRA-PANICKAR, Douglas J. SHEFFLER, John Howard HUTCHINSON, Reto Andreas GADIENT
  • Metabotropic glutamate receptor negative allosteric modulators (NAMs) and uses thereof
    Patent number: 10597367
    Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.
    Type: Grant
    Filed: April 11, 2018
    Date of Patent: March 24, 2020
    Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    Inventors: Nicholas David Peter Cosford, Dhanya Raveendra-Panickar, Douglas J. Sheffler, John Howard Hutchinson, Reto Andreas Gadient
  • Metabotropic glutamate receptor positive allosteric modulators (PAMS) and uses thereof
    Patent number: 10377695
    Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor positive allosteric modulators (PAMS), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: August 13, 2019
    Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    Inventors: Raveendra Panickar Dhanya, Douglas J. Sheffler, Nicholas D. P. Cosford
  • METABOTROPIC GLUTAMATE RECEPTOR NEGATIVE ALLOSTERIC MODULATORS (NAMS) AND USES THEREOF
    Publication number: 20190016715
    Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.
    Type: Application
    Filed: April 11, 2018
    Publication date: January 17, 2019
    Inventors: Nicholas David Peter COSFORD, Dhanya RAVEENDRA-PANICKAR, Douglas J. SHEFFLER
  • Metabotropic glutamate receptor positive allosteric modulators (PAMS) and uses thereof
    Patent number: 10099993
    Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor positive allosteric modulators (PAMS), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: October 16, 2018
    Assignee: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventors: Raveendra Panickar Dhanya, Douglas J. Sheffler, Nicholas D. P. Cosford, Russell Dahl
  • Metabotropic Glutamate Receptor Positive Allosteric Modulators (PAMS) and Uses Thereof
    Publication number: 20180194710
    Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor positive allosteric modulators (PAMS), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
    Type: Application
    Filed: November 21, 2017
    Publication date: July 12, 2018
    Inventors: Raveendra Panickar Dhanya, Douglas J. Sheffler, Nicholas D. P. Cosford
  • Metabotropic glutamate receptor negative allosteric modulators (NAMS) and uses thereof
    Patent number: 9969726
    Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: May 15, 2018
    Assignee: SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE
    Inventors: Nicholas David Peter Cosford, Dhanya Raveendra-Panickar, Douglas J. Sheffler
  • Metabotropic Glutamate Receptor Negative Allosteric Modulators (NAMS) and Uses Thereof
    Publication number: 20170217951
    Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.
    Type: Application
    Filed: June 9, 2015
    Publication date: August 3, 2017
    Applicant: Sanford-Burnham Medical Research Institute
    Inventors: Nicholas David Peter COSFORD, DHANYA Raveendra-Panickar, Douglas J. SHEFFLER
  • Metabotropic Glutamate Receptor Positive Allosteric Modulators (PAMS) and Uses Thereof
    Publication number: 20170036987
    Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor positive allosteric modulators (PAMS), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
    Type: Application
    Filed: April 6, 2015
    Publication date: February 9, 2017
    Inventors: Raveendra Panickar DHANYA, Douglas J. SHEFFLER, Nicholas D. P. COSFORD
  • 3.1.0 bicyclic GlyT1 inhibitors and methods of making and using same
    Patent number: 8497289
    Abstract: In one aspect, the invention relates to compounds which are useful as inhibitors of glycine type 1 transporter (GlyT1) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (GlyT1) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: December 29, 2009
    Date of Patent: July 30, 2013
    Assignee: Vanderbilt University
    Inventors: Craig W. Lindsley, P. Jeffrey Conn, Richard Williams, Carrie K. Jones, Douglas J. Sheffler
  • Sulfonyl-piperidin-4-yl methylamine amide analogs as GlyT1 inhibitors, methods for making same, and use of same in treating psychiatric disorders
    Patent number: 8436019
    Abstract: In one aspect, the invention relates to compounds which are useful as inhibitors of glycine type 1 transporter (GlyT1) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (GlyT1) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: May 7, 2013
    Assignee: Vanderbilt University
    Inventors: Craig W. Lindsley, P. Jeffrey Conn, Richard Williams, Carrie K. Jones, Douglas J. Sheffler
  • Alkylsulfonyl-2,3-dihydrospiro[indene-1,4?-piperidine] analogs as GlyT1 inhibitors, methods for making same, and use of same in treating psychiatric disorders
    Patent number: 8431700
    Abstract: In one aspect, the invention relates to compounds which are useful as inhibitors of glycine type 1 transporter (GlyT1) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (GlyT1) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: March 3, 2010
    Date of Patent: April 30, 2013
    Assignee: Vanderbilt University
    Inventors: Craig W. Lindsley, P. Jeffrey Conn, Richard Williams, Carrie K. Jones, Douglas J. Sheffler
  • 3.3.0 bicyclic GlyT1 inhibitors and methods of making and using same
    Patent number: 8211933
    Abstract: In one aspect, the invention relates to compounds which are useful as as inhibitors of glycine type 1 transporter (GlyT1) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (GlyT1) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: July 3, 2012
    Assignee: Vanderbilt University
    Inventors: Craig W. Lindsley, P. Jeffrey Conn, Richard Williams, Douglas J. Sheffler
  • Sulfonyl-azetidin-3-yl-methylamine amide analogs as GlyTl inhibitors, methods for making same, and use of same in treating psychiatric disorders
    Patent number: 8207155
    Abstract: In one aspect, the invention relates to compounds which are useful as inhibitors of glycine type 1 transporter (GlyT1) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (GlyT1) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: March 31, 2010
    Date of Patent: June 26, 2012
    Assignee: Vanderbilt University
    Inventors: Craig W. Lindsley, P. Jeffrey Conn, Richard Williams, Carrie K. Jones, Douglas J. Sheffler
  • 3.3.0 BICYCLIC GlyT1 INHIBITORS AND METHODS OF MAKING AND USING SAME
    Publication number: 20100261773
    Abstract: In one aspect, the invention relates to compounds which are useful as as inhibitors of glycine type 1 transporter (GlyT1) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (GlyT1) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: December 11, 2009
    Publication date: October 14, 2010
    Inventors: Craig W. Lindsley, P. Jeffrey Conn, Richard Williams, Douglas J. Sheffler
  • SULFONYL-AZETIDIN-3-YL-METHYLAMINE AMIDE ANALOGS AS GLYT1 INHIBITORS, METHODS FOR MAKING SAME, AND USE OF SAME IN TREATING PSYCHIATRIC DISORDERS
    Publication number: 20100261696
    Abstract: In one aspect, the invention relates to compounds which are useful as as inhibitors of glycine type 1 transporter (G1yT1) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (G1yT1) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: March 31, 2010
    Publication date: October 14, 2010
    Inventors: Craig W. Lindsley, P. Jeffrey Conn, Richard Williams, Carrie K. Jones, Douglas J. Sheffler
  • 3.1.0 BICYCLIC GLYT1 INHIBITORS AND METHODS OF MAKING AND USING SAME
    Publication number: 20100256192
    Abstract: In one aspect, the invention relates to compounds which are useful as as inhibitors of glycine type 1 transporter (GlyT1) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (GlyT1) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: December 29, 2009
    Publication date: October 7, 2010
    Inventors: Craig W. Lindsley, P. Jeffrey Conn, Richard Williams, Carrie K. Jones, Douglas J. Sheffler
  • SULFONYL-PIPERIDIN-4-YL METHYLAMINE AMIDE ANALOGS AS GLYT1 INHIBITORS, METHODS FOR MAKING SAME, AND USE OF SAME IN TREATING PSYCHIATRIC DISORDERS
    Publication number: 20100256186
    Abstract: In one aspect, the invention relates to compounds which are useful as inhibitors of glycine type 1 transporter (GlyT1) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (GlyT1) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: March 31, 2010
    Publication date: October 7, 2010
    Inventors: Craig W. Lindsley, P. Jeffrey Conn, Richard Williams, Carrie K. Jones, Douglas J. Sheffler