Patents by Inventor Douglas S. Clark

Douglas S. Clark has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240033685
    Abstract: An integrated, modular system for direct air capture (DAC) and electro-microbial production (EMP) for bioelectrochemical conversion of CO2 comprises (a) a solid absorbent configured to directly capture CO2 from air; (b) a first bioreactor configured to receive enriched and purified CO2 from the absorbent and convert the CO2 to an upgradeable organic carbon intermediate by an autotrophic microorganism, wherein the autotrophic organism derives energy from oxidation of electrochemically-generated reducing equivalents; and (c) a second bioreactor configured to receive the organic carbon intermediate from the first bioreactor for use as a feedstock by a metabolically engineered microorganism to generate a value added product.
    Type: Application
    Filed: October 7, 2023
    Publication date: February 1, 2024
    Applicant: The Regents of the University of California
    Inventors: Douglas S. Clark, Omar M. Yaghi, Peidong Yang, Anthony Abel, Jeremy Adams, Stefano Cestellos-Blanco, Hao Lyu, Ayan Zhumekenov
  • Patent number: 11518768
    Abstract: The present invention is drawn to artificial metalloenzymes for use in cyclopropanation reactions, amination and C—H insertion.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: December 6, 2022
    Assignee: The Regents of the University of California
    Inventors: John F. Hartwig, Hanna M. Key, Pawel Dydio, Douglas S. Clark
  • Publication number: 20210284972
    Abstract: The present invention provides for a genetically modified host cell capable of producing an unnatural compound, such as terpenoid, comprising a P450 enzyme comprising an artificial cofactor, and the host cell is capable of uptaking the artificial cofactor by comprising a heterologous heme transport transmembrane protein, or homologue thereof.
    Type: Application
    Filed: March 12, 2021
    Publication date: September 16, 2021
    Inventors: Jing Huang, Zhennan Liu, Douglas S. Clark, Jay D. Keasling, Aindrila Mukhopadhyay, John F. Hartwig
  • Publication number: 20180305368
    Abstract: The present invention is drawn to artificial metalloenzymes for use in cyclopropanation reactions, amination and C—H insertion.
    Type: Application
    Filed: April 13, 2018
    Publication date: October 25, 2018
    Inventors: John F. Hartwig, Hanna M. Key, Pawel Dydio, Douglas S. Clark
  • Publication number: 20180168202
    Abstract: The present invention provides improved apparatus and methods for the monitoring and control of apparatus designed to remove moisture from an initially wet product, such as a continuous dryer (14). The net rate of water removal from the wet product (16) is determined during drying thereof, preferably on a real-time basis. A control assembly (20) is operatively coupled with the dryer (14) and includes sensors (24, 26, 28, 34), which are operatively coupled with a digital controller (38). The controller (38) has a PID controller operable to continuously determine the average net rate of water removal from the product (16).
    Type: Application
    Filed: October 25, 2017
    Publication date: June 21, 2018
    Applicant: Wenger Manufacturing, Inc.
    Inventors: Adrian L. Strahm, Keith A. Erdley, Scott E. VanDalsem, Adam S. Hinton, Douglas S. Clark
  • Patent number: 9856427
    Abstract: The present disclosure provides methods to produce ketones suitable for use as fuels and lubricants by catalytic conversion of an acetone-butanol-ethanol (ABE) fermentation product mixture that can be derived from biomass.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: January 2, 2018
    Assignees: The Regents of the University of California, BP Corporation North America Inc.
    Inventors: F. Dean Toste, Pazhamalai Anbarasan, Joseph B. Binder, Paul A. Willems, Douglas S. Clark, Zach Baer, Sanil Sreekumar, Harvey W. Blanch
  • Patent number: 9848628
    Abstract: The present invention provides improved apparatus and methods for the monitoring and control of apparatus designed to remove moisture from an initially wet product, such as a continuous dryer (14). The net rate of water removal from the wet product (16) is determined during drying thereof, preferably on a real-time basis. A control assembly (20) is operatively coupled with the dryer (14) and includes sensors (24, 26, 28, 34), which are operatively coupled with a digital controller (38). The controller (38) has a PID controller operable to continuously determine the average net rate of water removal from the product (16).
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: December 26, 2017
    Assignee: Wenger Manufacturing, Inc.
    Inventors: Adrian L. Strahm, Keith A. Erdley, Scott E. VanDalsem, Adam S. Hinton, Douglas S. Clark
  • Patent number: 9848629
    Abstract: The present invention provides improved apparatus and methods for the monitoring and control of apparatus designed to remove moisture from an initially wet product, such as a continuous dryer (14). The net rate of water removal from the wet product (16) is determined during drying thereof, preferably on a real-time basis. A control assembly (20) is operatively coupled with the dryer (14) and includes sensors (24, 26, 28, 34), which are operatively coupled with a digital controller (38). The controller (38) has a PID controller operable to continuously determine the average net rate of water removal from the product (16).
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: December 26, 2017
    Assignee: Wenger Manufacturing, Inc.
    Inventors: Adrian L. Strahm, Keith A. Erdley, Scott E. VanDalsem, Adam S. Hinton, Douglas S. Clark
  • Patent number: 9790444
    Abstract: The present disclosure generally relates to the catalytic conversion of alcohols into hydrocarbon ketones suitable for use as fuels. More specifically, the present disclosure relates to the catalytic conversion of a mixture of isopropanol-butanol-ethanol (IBE) or acetone-butanol-ethanol (ABE), into ketones suitable for use as fuels. The ABE or IBE mixtures may be obtained from the fermentation of biomass or sugars.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: October 17, 2017
    Assignees: The Regents of the University of California, BP Corporation North America Inc.
    Inventors: Zachary C. Baer, Harvey W. Blanch, Douglas S. Clark, Sanil Sreekumar, F. Dean Toste, Gorkem Gunbas, Konstantinos A. Goulas, Amit A. Gokhale, Joseph B. Binder
  • Patent number: 9410135
    Abstract: The present disclosure relates to mutant thermostable glycosyl hydrolases family 7 enzymes, including mutant Trichoderma reesei endoglucanase I. In particular, the present disclosure relates to mutant thermostable enzymes, compositions containing the enzymes, and methods of use thereof.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: August 9, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Harshal Akshay Chokhawala, Tae-Wan Kim, Harvey W. Blanch, Douglas S. Clark
  • Publication number: 20160152907
    Abstract: The present disclosure generally relates to the catalytic conversion of alcohols into hydrocarbon ketones suitable for use as fuels. More specifically, the present disclosure relates to the catalytic conversion of a mixture of isopropanol-butanol-ethanol (IBE) or acetone-butanol-ethanol (ABE), into ketones suitable for use as fuels. The ABE or IBE mixtures may be obtained from the fermentation of biomass or sugars.
    Type: Application
    Filed: April 25, 2014
    Publication date: June 2, 2016
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, BP CORPORATION NORTH AMERICA INC.
    Inventors: Zachary C. BAER, Harvey W. BLANCH, Douglas S. CLARK, Sanil SREEKUMAR, F. Dean TOSTE, Gorkem GUNBAS, Konstantinos A. GOULAS, Amit A. GOKHALE, Joseph B. BINDER
  • Patent number: 9334515
    Abstract: Hydrolysis and degradation of cellulose-containing biomass by use of a polypeptide having cellulase activity is provided. Also provided are polypeptides having cellulase activity, such as archaeal cellulases, polynucleotides encoding the polypeptides, and compositions containing the polypeptides, and methods of use thereof.
    Type: Grant
    Filed: July 14, 2011
    Date of Patent: May 10, 2016
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Joel Edward Graham, Melinda E. Clark, Frank Thomson Robb, Douglas S. Clark, Harvey W. Blanch
  • Publication number: 20150211037
    Abstract: Hydrolysis and degradation of cellulose-containing biomass by use of a polypeptide having cellulase activity is provided. Also provided are polypeptides having cellulase activity, such as archaeal cellulases, polynucleotides encoding the polypeptides, and compositions containing the polypeptides, and methods of use thereof.
    Type: Application
    Filed: July 14, 2011
    Publication date: July 30, 2015
    Applicants: University of Maryland, Baltimore, The Regents of the University of California
    Inventors: Joel Edward Graham, Melinda E. Clark, Frank Thomson Robb, Douglas S. Clark, Harvey W. Blanch
  • Publication number: 20150037845
    Abstract: The present disclosure relates to mutant thermostable glycosyl hydrolases family 7 enzymes, including mutant Trichoderma reesei endoglucanase I. In particular, the present disclosure relates to mutant thermostable enzymes, compositions containing the enzymes, and methods of use thereof.
    Type: Application
    Filed: August 11, 2011
    Publication date: February 5, 2015
    Applicant: The Regents of the University of California
    Inventors: Harshal Akshay Chokhawala, Tae-Wan Kim, Harvey W. Blanch, Douglas S. Clark
  • Publication number: 20140137465
    Abstract: The present disclosure provides methods to produce ketones suitable for use as fuels and lubricants by catalytic conversion of an acetone-butanol-ethanol (ABE) fermentation product mixture that can be derived from biomass.
    Type: Application
    Filed: April 26, 2012
    Publication date: May 22, 2014
    Applicants: BP Corporation North America Inc., The Regents of the Universtiy of California
    Inventors: F. Dean Toste, Pazhamalai Anbarasan, Joseph B. Binder, Paul A. Willems, Douglas S. Clark, Zach Baer, Sanil Sreekumar, Harvey W. Blanch
  • Patent number: 8685729
    Abstract: The invention provides methods and compositions for increasing tolerance of microorganisms to toxic agents, such as solvents; and for increasing production of solvents from solvent-generating microorganisms. The methods comprise engineering a microorganism of interest to express a heterologous heat-shock protein/chaperone, e.g., Group II chaperonin or a prefoldin such as ?-prefoldin, where the heterologous protein is from an extremophile, such as an archaean.
    Type: Grant
    Filed: February 26, 2008
    Date of Patent: April 1, 2014
    Assignees: The Regents of the University of California, University of Maryland, Baltimore
    Inventors: Douglas S. Clark, Timothy Whitehead, Frank T. Robb, Pongpan Laksanalamai, Anchalee Jiemjit
  • Publication number: 20110190162
    Abstract: The invention is directed to a three-dimensional cell culture array comprising spatially-separated matrices attached to a solid support, wherein a plurality of said matrices encapsulate cells transfected with nucleic acids, method for the preparation of the array and methods reducing the expression of a target gene.
    Type: Application
    Filed: November 12, 2010
    Publication date: August 4, 2011
    Inventors: Moo-Yeal Lee, Seok Joon Kwon, Jonathan S. Dordick, Douglas S. Clark, Jessica R. McKinley
  • Publication number: 20110045554
    Abstract: The invention provides methods and compositions for increasing tolerance of microorganisms to toxic agents, such as solvents; and for increasing production of solvents from solvent-generating microorganisms. The methods comprise engineering a microorganism of interest to express a heterologous heat-shock protein/chaperone, e.g., Group II chaperonin or a prefoldin such as ?-prefoldin, where the heterologous protein is from an extremophile, such as an archaean.
    Type: Application
    Filed: February 26, 2008
    Publication date: February 24, 2011
    Applicants: The Regents of the University of California, University of Maryland, Baltimore
    Inventors: Douglas S. Clark, Timothy Whitehead, Frank T. Robb, Pongpan Laksanalamai, Anchalee Jiemjit
  • Publication number: 20110015088
    Abstract: A system and method for conducting high-throughput interactions between test compositions and analytes, comprising one or more test compositions, and a plurality of independent micromatrices, wherein each said micromatrix encapsulates at least one said test composition; and said micromatrices are made of a material that is permeable to an analyte.
    Type: Application
    Filed: June 21, 2010
    Publication date: January 20, 2011
    Applicants: Rensselaer Polytechnic Institute, The Regents of the University of California
    Inventors: Jonathan S. Dordick, Douglas S. Clark
  • Patent number: 7846747
    Abstract: A system and method for conducting high-throughput interactions between test compositions and analytes, comprising one or more test compositions, and a plurality of independent micromatrices, wherein each said micromatrix encapsulates at least one said test composition; and said micromatrices are made of a material that is permeable to an analyte.
    Type: Grant
    Filed: November 13, 2006
    Date of Patent: December 7, 2010
    Assignees: Rensselaer Polytechnic Institute, The Regents of the University of California
    Inventors: Jonathan S. Dordick, Douglas S. Clark