Patents by Inventor Douglas S. McNair

Douglas S. McNair has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10468137
    Abstract: Systems and methods are provided for managing treatment of children with a congenital cyanotic heart condition such as Tetralogy of Fallot (ToF) including determining predicted survival probabilities within a timeframe wherein patients await medical treatment such as surgical correction, based on amounts of a biomarker, such as BNP (brain natriuretic peptide) in serial samples of blood plasma from the subject and determining a Tetralogy of Fallot Index (TOFI®) score from the biomarker values. Some embodiments use TOFI score to determine severity and include scheduling and prioritizing medical treatment for patients based on the severity. In some embodiments, the TOFI score is calculated from a plurality of biomarker measurements, which are log-transformed and z-score transformed, by a mathematical survival predictive model, such as a Cox Proportional Hazards model.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: November 5, 2019
    Assignee: Cerner Innovation, Inc.
    Inventors: Douglas S. McNair, Sasanka Are, Kanakasabha Kailasam
  • Patent number: 10468138
    Abstract: A system, methods, and computer-readable media are provided for the automatic identification of patients having an elevated near-term risk of pulmonary function deterioration or respiratory distress. Embodiments of the invention are directed to event prediction, risk stratification, and optimization of the assessment, communication, and decision-making to prevent respiratory events in humans, and in one embodiment take the form of a platform for wearable, mobile, untethered monitoring devices with embedded decision support. Respiratory information is obtained over one or a plurality of previous time intervals, to classify a likelihood of events leading to an acute respiratory decompensation event within a future time interval. In an embodiment, the risk prediction is based a plurality of nonlinearity measures of capnometry information over the previous time interval(s), and the risk for an acute respiratory decompensation event determined using an ensemble model predictor on the nonlinearity measures.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: November 5, 2019
    Assignee: Cerner Innovation, Inc.
    Inventor: Douglas S. McNair
  • Patent number: 10460035
    Abstract: Technologies are provided for determining deficiencies in narrative textual data that may impact decision-making in a decisional context. A candidate text document and a reference corpus of text may be utilized to generate one or more topic models and document-term matrices, and then to determine a corresponding statistical perplexity and probabilistic coherence. The reference corpus may be known or normatively deemed to be epistemically persuasive and adequate with respect to a particular context. Statistical determinations of a degree to which the candidate deviates from the reference normative corpus are determined, in terms of the statistical perplexity and probabilistic coherence of the candidate as compared to the reference.
    Type: Grant
    Filed: December 26, 2017
    Date of Patent: October 29, 2019
    Assignee: Cerner Innovation, Inc.
    Inventor: Douglas S. McNair
  • Patent number: 10446273
    Abstract: Systems, methods and computer-readable media are provided for facilitating clinical decision support and managing patient population health by health-related entities including caregivers, health care administrators, insurance providers, and patients.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: October 15, 2019
    Assignee: Cerner Innovation, Inc.
    Inventors: Douglas S. McNair, John Christopher Murrish, Kanakasabha Kailasam
  • Patent number: 10431336
    Abstract: A system, method, and computer-readable media are provided for facilitating clinical decision making, and in particular, facilitating treatment of a person having congestive heart failure. The method includes the step of receiving patient information for a patient. The method also includes the steps of determining whether the patient information suggests a trigger event, and upon determining a trigger event, determining at least one goal associated with the trigger event. The method also includes the steps of selecting a first plan, from a library of plans, corresponding to the goal and executing the plan, which further includes determining a solver to determine patient conditions or recommended treatments, receiving parameters for the determined solver, and preparing patient information for the determined solver.
    Type: Grant
    Filed: September 30, 2011
    Date of Patent: October 1, 2019
    Assignee: CERNER INNOVATION, INC.
    Inventors: John Christopher Murrish, Douglas S. McNair, Kanakasabha Kailasam
  • Patent number: 10420486
    Abstract: Methods, computer systems, and computer readable media are provided for promoting positive activity patterns for users and facilitate long-term adherence to the activity patterns, such as by providing alerts or electronic reminders to ambulate in a fashion that is responsive to an individual's actual activity patterns and behaviors and compatible with routine activities in the workplace and home. In particular, embodiments of the present invention are directed to (1) measuring physical activity patterns during the waking hours of a human, and in some embodiments continuously measuring these activity patterns; (2) automatically ascertaining whether the patterns exhibit sufficient frequency and variability of activity such as confers certain health benefits; and (3) if the patterns do not manifest such features, to adaptively provide sensible reminders at irregular within-day intervals such as are likely to establish healthy patterns of ambulation and other light activity.
    Type: Grant
    Filed: January 28, 2013
    Date of Patent: September 24, 2019
    Assignee: Cerner Innovation, Inc.
    Inventor: Douglas S. McNair
  • Patent number: 10410750
    Abstract: A system, methods, and computer-readable media are provided for the automatic identification of patients having an elevated near-term risk of pulmonary function deterioration or respiratory distress. Embodiments of the invention are directed to event prediction, risk stratification, and optimization of the assessment, communication, and decision-making to prevent respiratory events in humans, and in one embodiment take the form of a platform for wearable, mobile, untethered monitoring devices with embedded decision support. Respiratory information is obtained over one or a plurality of previous time intervals, to classify a likelihood of events leading to an acute respiratory decompensation event within a future time interval. In an embodiment, the risk prediction is based a plurality of nonlinearity measures of capnometry information over the previous time interval(s), and the risk for an acute respiratory decompensation event determined using an ensemble model predictor on the nonlinearity measures.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: September 10, 2019
    Assignee: Cerner Innovation, Inc.
    Inventor: Douglas S. McNair
  • Patent number: 10405810
    Abstract: A tool for predicting that a person is likely to be abnormally hydrated over a future time interval, and in some cases to alert the person or a medical professional to intervene. From a series of physiological measurements, a tissue electrical impedance spectrum curve, which comprises a phase spectrum curve in an embodiment, is determined and changes in the shape of the curve are ascertained. The measurements may be received using one or more sensors worn by the person. In some embodiments, current and historic spectrum curvature are applied to an evolutionary algorithm, such as particle-swarm optimization (PSO) or differential evolution (DE), to determine an inference regarding the persons future hydration status. In one embodiment, a statistical forecast for the next epoch immediately beyond the present one, is determined.
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: September 10, 2019
    Assignee: Cerner Innovation, Inc.
    Inventor: Douglas S. McNair
  • Patent number: 10390765
    Abstract: A catastrophe-theoretic approach is provided for predicting an occurrence of an ischemic myocardial event (e.g., acute myocardial infarction) for a human patient based on a time series of monitored vital signs values measured from a patient, and in some instances, for providing advanced notice to clinicians or caregivers when such an ischemic event is forecasted or modifying treatment for the patient, according to the predicted likelihood. In particular, an ischemic heart disease management system is provided for determining a likelihood of near-term future significant myocardial ischemia in persons with coronary artery disease. Embodiments of the disclosure described herein may provide a forecasted risk for future significant myocardial ischemia within a time horizon comprising a future time interval. In one embodiment, the future time interval is from 30 min to approximately 4 hours into the future, and may be dependent on the frequency of vital signs measurements.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: August 27, 2019
    Assignee: Cerner Innovation, Inc.
    Inventor: Douglas S. McNair
  • Patent number: 10387621
    Abstract: An optimization methodology is employed to match vibratory inhaler devices having certain characteristics to the particular anatomical and acoustic properties of a patient's vocal tract, in order to achieve the most effective dispersion of a dry powder medicament using inspiratory effort of a user of the inhaler. In embodiments, optimization involves employing one or more measurements of acoustic frequency spectrum properties as well as one or more anatomical/geometric measurements of the structures comprising the particular patient's mouth, pharynx, and upper respiratory tract and matching a vibratory inhalation device that corresponds thereto.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: August 20, 2019
    Assignee: CERNER INNOVATION, INC.
    Inventor: Douglas S. McNair
  • Patent number: 10354751
    Abstract: A system, method, and computer-readable media are provided for facilitating clinical decision making, and in particular, decision making based on a third party's clinical situation by determining and providing useful, up-to-date information, such as patient-related information to a decision maker. In one embodiment, a user first identifies an information item concerning a patient. Based on that item, a set of related information items is determined and prioritized, and a reference pointer, which identifies the set of related information, is generated. The reference pointer is communicated to the user's mobile device. Subsequently, the user's mobile device requests information from the set of information items associated with the reference pointer, and provides information authorization information. Following authentication of the user's credentials, updates of information from the set of information items is communicated to the user's mobile device as they become available.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: July 16, 2019
    Assignee: CERNER INNOVATION, INC.
    Inventor: Douglas S. McNair
  • Patent number: 10348637
    Abstract: Systems, methods, and computer-readable media are provided for facilitating system optimization through the use of user-resource allocations to servers based on determined access patterns. In one embodiment, recurrent patterns of access are identified based on combinations of computer system users and system-hosted resources. In some embodiments, groupings of user-resource combinations can be determined. The groupings are valuable for optimizing the allocation of users and/or resources to a plurality of servers, particularly under conditions of heavy simultaneous resource demand. Patterns may be determined from user-resource pair access time series, and groupings may be determined based on derived strength of association of these. Based on the groupings, users and resources may be allocated to servers efficiently. Allocation optimization can be an effective means for mitigating or preventing Service Level Agreement non-compliance.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: July 9, 2019
    Assignee: Cerner Innovation, Inc.
    Inventor: Douglas S. McNair
  • Patent number: 10339618
    Abstract: A computer-implemented trading platform, system, and method are provided for facilitating the trading and accounting for health quality offsets. So-called “health quality credits” related to emissions of ‘potentially avoidable complications’ (PACs) or ‘potentially avoidable mortality’ (PAMs). Emissions trading or “cap-and-trade” is an administrative approach used to control emissions that degrade public-goods assets by providing economic incentives for achieving and sustaining economically significant reductions in the emissions of pollutants that impair public goods such as clean air or health.
    Type: Grant
    Filed: October 3, 2012
    Date of Patent: July 2, 2019
    Assignee: Cerner Innovation, Inc.
    Inventors: Douglas S. McNair, Kiran Kambhampati
  • Publication number: 20190129901
    Abstract: Methods, systems, and computer-readable media are provided for facilitating mapping of semantically similar terms between and among two or more information systems. In particular, to facilitate automatic discovery, establishment, and/or statistical validation of linkages between a plurality of different nomenclatures employed by a plurality of information systems, such as multiple electronic health record systems. In embodiments, the imputation of latent synonymy in corpora comprised of samples of historical records from each system enables automated terminology mapping between disparate systems' records, thereby establishing reliable linkages that may subsequently be utilized for realtime decision support, data mining-based research, or other valuable purposes.
    Type: Application
    Filed: December 19, 2018
    Publication date: May 2, 2019
    Inventors: Douglas S. McNair, Kanakasabha K. Kailasam, John Christopher Murrish
  • Patent number: 10268687
    Abstract: Systems, methods and computer-readable media are provided for facilitating patient health care by providing discovery, validation, and quality assurance of nomenclatural linkages between pairs of terms or combinations of terms in databases extant on multiple different health information systems that do not share a set of unified codesets, nomenclatures, or ontologies, or that may in part rely upon unstructured free-text narrative content instead of codes or standardized tags. Embodiments discover semantic structures existing naturally in documents and records, including relationships of synonymy and polysemy between terms arising from disparate processes, and maintained by different information systems. In some embodiments, this process is facilitated by applying Latent Semantic Analysis in concert with decision-tree induction and similarity metrics.
    Type: Grant
    Filed: December 28, 2016
    Date of Patent: April 23, 2019
    Assignee: CERNER INNOVATION, INC.
    Inventors: Douglas S. McNair, John Christopher Murrish, Kanakasabha Kailasam
  • Patent number: 10249385
    Abstract: Methods, systems, and computer-readable media are provided for facilitating record matching and entity resolution and for enabling improvements in record linkage. A power-spectrum-based temporal pattern-specific weight may be incorporated into record linkage methods to enhance the record linkage accuracy and statistical performance. For example, in embodiments, a value-specific weight may be calculated from a population-based frequency of field-specific values and provides an opportunity to capture and measure the relative importance of specific values found in a field. A timeseries-derived Bayesian power spectrum weight may be calculated from the population-based frequency of temporal pattern-specific values in terms of intensities at various frequencies of the power spectrum computed from the timeseries, and further provides an opportunity to capture and measure the relative importance of specific sequences of care episodes.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: April 2, 2019
    Assignee: Cerner Innovation, Inc.
    Inventors: Douglas S. McNair, Kanakasabha Kailasam, John Christopher Murrish
  • Patent number: 10213145
    Abstract: Optimizing psychiatric and physiologic monitoring of a patient having PTSD or anxiety-related mental health condition. According to an embodiment, one or more physiological variables are longitudinally measured; resting heart rate is measured from which a timeseries is constructed; outlier anomalous values are removed from the timeseries, it is de-trended and/or de-meaned; and a serial normal sinus rhythm beats (SDNN) and/or other parameters are determined. Fractal properties of the serial SDNN values are calculated, such as the Hurst exponent alpha via detrended fluctuation analysis (DFA) or spectral regression; and other measures of chaos and nonlinearity are calculated, such as the Shannon entropy of the SDNN or related timeseries. Where such measures indicate a statistically-significant transgression of a context-indexed reference range, a notification is provided to a case management clinician or caregiver so that appropriate additional evaluation and diagnosis and treatment may be undertaken.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: February 26, 2019
    Assignee: Cerner Innovation, Inc.
    Inventor: Douglas S. McNair
  • Patent number: 10198499
    Abstract: Methods, systems, and computer-readable media are provided for facilitating mapping of semantically similar terms between and among two or more information systems. In particular, to facilitate automatic discovery, establishment, and/or statistical validation of linkages between a plurality of different nomenclatures employed by a plurality of information systems, such as multiple electronic health record systems. In embodiments, the imputation of latent synonymy in corpora comprised of samples of historical records from each system enables automated terminology mapping between disparate systems' records, thereby establishing reliable linkages that may subsequently be utilized for realtime decision support, data mining-based research, or other valuable purposes.
    Type: Grant
    Filed: August 8, 2012
    Date of Patent: February 5, 2019
    Assignee: Cerner Innovation, Inc.
    Inventors: Douglas S. McNair, Kanakasabha K. Kailasam, John Christopher Murrish
  • Publication number: 20180333106
    Abstract: Methods and systems for predicting deterioration of a patient's condition within a future time interval based on a time series of values for monitored physiological variables measured from a patient, and in some instances, providing advanced notice to clinicians or caregivers when deterioration is forecasted or modifying treatment for the patient are provided. In particular, deterioration of a patient's condition is based on a Hopf bifurcation model and is predicted using a ratio of deviations for monitored physiological variables. A ratio of deviations relates the standard deviation and root mean square of successive differences for a set of physiological values measured over time. The RoD for one or more variables, such as heart rate, respiratory rate, and blood pressure, may be used to predict the likelihood of the patient's condition deteriorating into an unstable state as what occurs in a Hopf bifurcation.
    Type: Application
    Filed: May 18, 2018
    Publication date: November 22, 2018
    Inventors: ANDREW ROBERTS, SASANKA ARE, DOUGLAS S. McNAIR
  • Patent number: 10098582
    Abstract: Systems and methods are provided for quantitatively and objectively characterizing sleep architecture in normal individuals and persons with various health conditions. Embodiments of the invention facilitate characterizing temporal-pattern information of an individual's sleep, such as measured by electroencephalography (EEG), for identifying persons with abnormalities in the temporal-pattern information, sequences or durations of their stages of sleeping (“sleep architecture”), for facilitating selecting appropriate therapy or treatment, and for monitoring the effectiveness of such therapy or treatment. In one aspect, a set of time series are formed by electronically representing and storing information pertaining to brain activity, such as EEG hypnogram or sleep information, over a multi-night span.
    Type: Grant
    Filed: May 16, 2014
    Date of Patent: October 16, 2018
    Assignee: Cerner Innovations, Inc.
    Inventors: Douglas S. McNair, Kanakasabha Kailasam, William Stadler