Patents by Inventor Durgesh V. Nadkarni

Durgesh V. Nadkarni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purification of antibody drug conjugates using a sodium phosphate gradient
    Patent number: 11661438
    Abstract: Methods of removing high molecular weight species, in particular aggregates, from antibody drug conjugate preparations, by contacting preparations of the antibody drug conjugate reaction mixture with a hydroxyapatite resin and selectively eluting the ADC from the resin using a gradient comprising sodium phosphate.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: May 30, 2023
    Assignee: Pfizer, Inc.
    Inventors: Durgesh V. Nadkarni, Jeffry R. Borgmeyer, He Meng, Qingping Jiang
  • PURIFICATION OF ANTIBODY DRUG CONJUGATES USING A SODIUM PHOSPHATE GRADIENT
    Publication number: 20190367556
    Abstract: Methods of removing high molecular weight species, in particular aggregates, from antibody drug conjugate preparations, by contacting preparations of the antibody drug conjugate reaction mixture with a hydroxyapatite resin and selectively eluting the ADC from the resin using a gradient comprising sodium phosphate.
    Type: Application
    Filed: December 7, 2016
    Publication date: December 5, 2019
    Applicant: PFIZER INC.
    Inventors: Durgesh V. Nadkarni, Jeffry R. Borgmeyer, He Meng, Qingping Jiang
  • Method of depositing a metal film on a silyl hydride containing surface of a solid and products produced thereby
    Patent number: 5281440
    Abstract: A method of depositing a metal film on a silyl hydride surface of a solid such as silica gel, the solid normally having hydroxyl groups, the metal with a valence of zero being deposited on the surface by reaction of a metal ion in a solution with the hydrogens of the silyl hydrides. The above method is used to easily remove metal ions from a solution and also the method is a basis for determining the number of silyl hydride groups on the surface of the solid.
    Type: Grant
    Filed: April 1, 1992
    Date of Patent: January 25, 1994
    Assignee: The University of Toledo
    Inventors: James L. Fry, Durgesh V. Nadkarni