Patents by Inventor Duzhang Zhu
Duzhang Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7658931Abstract: Mutant cholera holotoxins having single or double amino acid substitutions or insertions have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in antigenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.Type: GrantFiled: December 19, 2007Date of Patent: February 9, 2010Assignees: Wyeth Holdings Corporation, The United States of America, as represented by the Uniformed Services University of Health SciencesInventors: Bruce A. Green, Randall K. Holmes, Michael G. Jobling, Duzhang Zhu
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Publication number: 20080311144Abstract: Mutant cholera holotoxins having single or double amino acid substitutions or insertions have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in antigenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.Type: ApplicationFiled: December 19, 2007Publication date: December 18, 2008Applicants: Wyeth Holdings Corporation, The Gov. of the USA, as represented by the Uniformed Services University of Health SciencesInventors: Bruce A. Green, Randall K. Holmes, Michael G. Jobling, Duzhang Zhu
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Publication number: 20080213303Abstract: Mutant cholera holotoxins comprising a cholera toxin subunit A having single amino acid substitutions in the amino acid positions 16 or 72 or a double amino acid substitution in the amino acid positions 16 and 68 or 68 and 72 have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in immunogenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.Type: ApplicationFiled: October 22, 2007Publication date: September 4, 2008Applicants: Wyeth Holdings Corporation, The Regents of the University of Colorado, A Body Corporate Health Science CenterInventors: Bruce A. Green, Randall K. Holmes, Michael G. Jobling, Duzhang Zhu
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Patent number: 7361355Abstract: Mutant cholera holotoxins comprising a cholera toxin subunit A having single amino acid substitutions in the amino acid positions 16 or 72 or a double amino acid substitution in the amino acid positions 16 and 68 or 68 and 72 have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in immunogenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.Type: GrantFiled: December 15, 2006Date of Patent: April 22, 2008Assignees: Wyeth Holdings Corporation, The Regents of the University of Colorado, A Body CorporateInventors: Bruce A. Green, Randall K. Holmes, Michael G. Jobling, Duzhang Zhu
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Patent number: 7332174Abstract: Mutant cholera holotoxins having single or double amino acid substitutions or insertions have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in antigenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.Type: GrantFiled: June 5, 2002Date of Patent: February 19, 2008Assignees: Wyeth Holdings Corporation, The United States of America as represented by the Uniformed Services University of Health SciencesInventors: Bruce A. Green, Randall K. Holmes, Michael G. Jobling, Duzhang Zhu
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Patent number: 7285281Abstract: Mutant cholera holotoxins comprising a cholera toxin subunit A having single amino acid substitutions in the amino acid positions 16 or 72 or a double amino acid substitution in the amino acid positions 16 and 68 or 68 and 72 have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in immunogenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.Type: GrantFiled: June 5, 2002Date of Patent: October 23, 2007Assignees: Wyeth Holdings Corporation, The Regents of the University of Colorado, A Body CorporateInventors: Bruce A. Green, Randall K. Holmes, Michael G. Jobling, Duzhang Zhu
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Publication number: 20070122428Abstract: Mutant cholera holotoxins having single or double amino acid substitutions or insertions have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in antigenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.Type: ApplicationFiled: December 22, 2006Publication date: May 31, 2007Applicants: Wyeth Holdings Corporation, University of Health SciencesInventors: Bruce Green, Randall Holmes, Michael Jobling, Duzhang Zhu
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Publication number: 20070116715Abstract: Mutant cholera holotoxins comprising a cholera toxin subunit A having single amino acid substitutions in the amino acid positions 16 or 72 or a double amino acid substitution in the amino acid positions 16 and 68 or 68 and 72 have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in immunogenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.Type: ApplicationFiled: December 15, 2006Publication date: May 24, 2007Applicants: Wyeth, University of ColoradoInventors: Bruce Green, Randall Holmes, Michael Jobling, Duzhang Zhu
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Publication number: 20040181036Abstract: Mutant cholera holotoxins comprising a cholera toxin subunit A having single amino acid substitutions in the amino acid positions 16 or 72 or a double amino acid substitution in the amino acid positions 16 and 68 or 68 and 72 have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in immunogenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.Type: ApplicationFiled: December 4, 2003Publication date: September 16, 2004Inventors: Bruce A Green, Randall K. Holmes, Michael G. Jobling, Duzhang Zhu
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Publication number: 20040176571Abstract: Mutant cholera holotoxins having single or double amino acid substitutions or insertions have reduced toxicity compared to the wild-type cholera holotoxin. The mutant cholera holotoxins are useful as adjuvants in antigenic compositions to enhance the immune response in a vertebrate host to a selected antigen from a pathogenic bacterium, virus, fungus, or parasite, a cancer cell, a tumor cell, an allergen, or a self-molecule.Type: ApplicationFiled: December 4, 2003Publication date: September 9, 2004Applicant: Wyeth Holdings CorporationInventors: Bruce A. Green, Randall K. Holmes, Michael G. Jobling, Duzhang Zhu