Patents by Inventor Dvin Adalian

Dvin Adalian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of producing thin enzyme-based sensing layers on planar sensors
    Patent number: 11690544
    Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.
    Type: Grant
    Filed: May 7, 2021
    Date of Patent: July 4, 2023
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Samson Chen, Axel Scherer, Dvin Adalian, Peter Petillo, Muhammad Musab Jilani, Xiomara L. Madero, Deepan Kishore Kumar
  • METHODS AND SYSTEMS FOR FABRICATING BIOSENSORS
    Publication number: 20230121718
    Abstract: Methods and systems are described for fabricating thin hydrogel layers on biosensors by a drop-spin method, which includes placing a drop of the hydrogel on the electrode, spinning the wafer at high speed in a vacuum, and heating the wafer to cure. One and multilayer sensors can be fabricated in this way, by adding layers of hydrogel or metal.
    Type: Application
    Filed: October 14, 2022
    Publication date: April 20, 2023
    Inventors: Oliver PLETTENBURG, Christin AHLBRECHT, Dvin ADALIAN, Axel SCHERER, Xiomara Linnette MADERO, Samson CHEN, Muhammad Musab JILANI
  • METAL-ENZYME SANDWICH LAYERS
    Publication number: 20220071529
    Abstract: Measurement of target analytes is carried out with an enzyme-based sensor. The enzyme hydrogel is protected by a porous layer of a metallic material. The size of the pores is small enough to prevent degradation of the enzyme layer caused by the immune system of an organism, but large enough to allow transfer of molecules that participate in the electrochemical reaction allowing the enzyme to detect the target analytes.
    Type: Application
    Filed: August 18, 2021
    Publication date: March 10, 2022
    Inventors: Dvin ADALIAN, Samson CHEN, Muhammad M. JILANI, Axel SCHERER, Xiomara Linnette MADERO, Richard SMITH
  • METHOD OF PRODUCING THIN ENZYME-BASED SENSING LAYERS ON PLANAR SENSORS
    Publication number: 20210321918
    Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.
    Type: Application
    Filed: May 7, 2021
    Publication date: October 21, 2021
    Inventors: Samson CHEN, Axel SCHERER, Dvin ADALIAN, Peter PETILLO, Muhammad Musab JILANI, Xiomara L. MADERO, Deepan KISHORE KUMAR
  • Metal-enzyme sandwich layers
    Patent number: 11109784
    Abstract: Measurement of target analytes is carried out with an enzyme-based sensor. The enzyme hydrogel is protected by a porous layer of a metallic material. The size of the pores is small enough to prevent degradation of the enzyme layer caused by the immune system of an organism, but large enough to allow transfer of molecules that participate in the electrochemical reaction allowing the enzyme to detect the target analytes.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: September 7, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Dvin Adalian, Samson Chen, Muhammad M. Jilani, Axel Scherer, Xiomara Linnette Madero, Richard Smith
  • Method of producing thin enzyme-based sensing layers on planar sensors
    Patent number: 11026610
    Abstract: A sensor implanted in tissues and including a sensing layer is fabricated by mixing the signal transduction enzyme with non-reactive components including buffer salts and fillers, and spin coating the enzyme onto a substrate. The signal transduction enzyme is crosslinked by introducing the coated substrate in a vacuum chamber. In the chamber, a crosslinker evaporates and is deposited onto the enzyme, therefore crosslinking the enzyme.
    Type: Grant
    Filed: September 27, 2018
    Date of Patent: June 8, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Samson Chen, Axel Scherer, Dvin Adalian, Peter Petillo, Muhammad Musab Jilani, Xiomara L. Madero, Deepan Kishore Kumar
  • METAL-ENZYME SANDWICH LAYERS
    Publication number: 20190307378
    Abstract: Measurement of target analytes is carried out with an enzyme-based sensor. The enzyme hydrogel is protected by a porous layer of a metallic material. The size of the pores is small enough to prevent degradation of the enzyme layer caused by the immune system of an organism, but large enough to allow transfer of molecules that participate in the electrochemical reaction allowing the enzyme to detect the target analytes.
    Type: Application
    Filed: November 14, 2018
    Publication date: October 10, 2019
    Inventors: Dvin ADALIAN, Samson CHEN, Muhammad M. JILANI, Axel SCHERER, Xiomara Linnette MADERO, Richard SMITH
  • Electrically actuated valves made from shape memory alloy wires embedded in elastomer
    Patent number: 8002235
    Abstract: Microfluidic valves constructed from elastomeric materials as the valve body components and employing shape memory alloy in wire form as the valve actuator. Various configurations of individual valves having both normally open and normally closed states are described. Apparatus using such valves and providing logic functionality with fluidic logic outputs are discussed. Apparatus that can be used for materials processing at the nano- or micro-scale are presented. Various forms of logical control of valve arrays are explained.
    Type: Grant
    Filed: September 11, 2007
    Date of Patent: August 23, 2011
    Assignee: California Institute of Technology
    Inventors: Saurabh Vyawahare, Suresh Situala, Dvin Adalian, Axel Scherer
  • ELECTRICALLY ACTUATED VALVES MADE FROM SHAPE MEMORY ALLOY WIRES EMBEDDED IN ELASTOMER
    Publication number: 20080173833
    Abstract: Microfluidic valves constructed from elastomeric materials as the valve body components and employing shape memory alloy in wire form as the valve actuator. Various configurations of individual valves having both normally open and normally closed states are described. Apparatus using such valves and providing logic functionality with fluidic logic outputs are discussed. Apparatus that can be used for materials processing at the nano- or micro-scale are presented. Various forms of logical control of valve arrays are explained.
    Type: Application
    Filed: September 11, 2007
    Publication date: July 24, 2008
    Applicant: California Institute of Technology
    Inventors: Saurabh Vyawahare, Suresh Sitaula, Dvin Adalian, Axel Scherer