Patents by Inventor Dvir Dahary

Dvir Dahary has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200354731
    Abstract: Isolated polynucleotides comprising a transcriptional unit are disclosed, the transcriptional unit comprising: (i) a nucleic acid sequence that encodes a secreted protein of interest; (ii) an endoplasmic reticulum (ER) targeting sequence as set forth in SEQ ID NO: 2, said ER targeting sequence being heterologous to said secreted protein of interest; (iii) a promoter; and (iv) a transcription termination site.
    Type: Application
    Filed: July 28, 2020
    Publication date: November 12, 2020
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Jeffrey E. GERST, Lisha Qiu Jin LIM, Yitzhak PILPEL, Tsviya OLENDER, Dvir DAHARY, Osnat COHEN-ZONTAG
  • Publication number: 20200316120
    Abstract: The present invention provides a method for identifying a target pair comprising i) an inhibitory chimeric antigen receptor (iCAR) or a protective chimeric antigen receptor (pCAR) capable of preventing or attenuating undesired activation of an effector immune cell, wherein the iCAR or pCAR target is directed to a target extracellular polymorphic epitope, and ii) an activating chimeric antigen receptor (aCAR), wherein the aCAR is directed to a target non-polymorphic cell surface epitope of a protein, as well as methods of making and use of such pairs in the treatment of cancer.
    Type: Application
    Filed: September 27, 2019
    Publication date: October 8, 2020
    Inventors: Gideon Gross, William J. Gibson, Dvir Dahary, Merav Beiman, Yael Sagi, Adi Sharbi-Yunger
  • Publication number: 20200261499
    Abstract: The present invention provides a method of identifying a target for preparing an inhibitory chimeric antigen receptor (iCAR) or a protective chimeric antigen receptor (pCAR) capable of preventing or attenuating undesired activation of an effector immune cell. Also provided are a list of iCAR targets, as well as vectors and transduced effector immune cells comprising the nucleic acid molecule and methods for treatment of cancer comprising administering the transduced effector immune cells are further provided.
    Type: Application
    Filed: September 28, 2018
    Publication date: August 20, 2020
    Inventors: Gideon Gross, Will Gibson, Dvir Dahary, Merav Beiman
  • Publication number: 20150307572
    Abstract: Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
    Type: Application
    Filed: February 23, 2015
    Publication date: October 29, 2015
    Inventors: Ronen Shemesh, Zurit Levine, Amir Toporik, Chen Hermesh, Yossef Kliger, Eyal Gofer, Assaf Wool, Dvir Dahary, Yossi Cohen
  • Patent number: 8987191
    Abstract: Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: March 24, 2015
    Assignee: Compugen Ltd.
    Inventors: Ronen Shemesh, Zurit Levine, Amir Toporik, Chen Hermesh, Yossef Kliger, Eyal Gofer, Assaf Wool, Dvir Dahary, Yossi Cohen
  • Publication number: 20150005227
    Abstract: Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
    Type: Application
    Filed: September 7, 2014
    Publication date: January 1, 2015
    Inventors: YOSSI COHEN, RONEN SHEMESH, AMIR TOPORIK, ZURIT LEVINE, ASSAF WOOL, DVIR DAHARY, IRIS HECHT, GALIT ROTMAN, MICHAL AYALON-SOFFER
  • Patent number: 8828940
    Abstract: Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
    Type: Grant
    Filed: December 14, 2010
    Date of Patent: September 9, 2014
    Assignee: Compugen Ltd.
    Inventors: Yossi Cohen, Ronen Shemesh, Amir Toporik, Zurit Levine, Assaf Wool, Dvir Dahary, Iris Hecht, Galit Rotman, Michal Ayalon-Soffer
  • Publication number: 20140005097
    Abstract: Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
    Type: Application
    Filed: June 21, 2013
    Publication date: January 2, 2014
    Applicant: Compugen Ltd.
    Inventors: Ronen Shemesh, Zurit Levine, Amir Toporik, Chen Hermesh, Yossef Kliger, Eyal Gofer, Assaf Wool, Dvir Dahary, Yossi Cohen
  • Patent number: 8492329
    Abstract: Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
    Type: Grant
    Filed: July 11, 2008
    Date of Patent: July 23, 2013
    Assignee: Compugen Ltd.
    Inventors: Ronen Shemesh, Zurit Levine, Amir Toporik, Chen Hermesh, Yossef Klinger, Eyal Gofer, Assaf Wool, Dvir Dahary, Yossi Cohen
  • Patent number: 8349801
    Abstract: Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating myocardial and ischemic disorders associated with G-protein coupled receptor activation.
    Type: Grant
    Filed: September 18, 2007
    Date of Patent: January 8, 2013
    Assignee: Compugen Ltd.
    Inventors: Yossi Cohen, Ronen Shemesh, Amir Toporik, Zurit Levine, Assaf Wool, Dvir Dahary, Iris Hecht, Merav Beiman, Galit Rotman, Michal Ayalon-Soffer
  • Publication number: 20120129776
    Abstract: Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
    Type: Application
    Filed: September 18, 2007
    Publication date: May 24, 2012
    Inventors: Yossi Cohen, Ronen Shemesh, Amir Toporik, Zurit Levine, Assaf Wool, Dvir Dahary, Iris Hecht, Merav Beiman, Galit Rotman, Michal Ayalon-Soffer
  • Publication number: 20110212051
    Abstract: Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention. Also provided are methods and kits for diagnosing, determining predisposition and/or prognosis of various disorders using as diagnostic markers the novel polypeptides and polynucleotides of the present invention.
    Type: Application
    Filed: February 28, 2011
    Publication date: September 1, 2011
    Inventors: Michal Ayalon-Soffer, Zurit Levine, Osnat Sella-Tavor, Alex Diber, Ronen Shemesh, Amir Toporik, Galit Rotman, Sergey Nemzer, Avi Rosenberg, Dvir Dahary, Assaf Wool, Gad S. Cojocaru, Pinchas Akiva, Sarah Pollock, Kinneret Savitsky, Jeanne Bernstein
  • Publication number: 20110183924
    Abstract: A method of annotating biomolecular sequences. The method comprises (a) computationally clustering the biomolecular sequences according to a progressive homology range, to thereby generate a plurality of clusters each being of a predetermined homology of the homology range; and (b) assigning at least one ontology to each cluster of the plurality of clusters, the at least one ontology being: (i) derived from an annotation preassociated with at least one biomolecular sequence of each cluster; and/or (ii) generated from analysis of the at least one biomolecular sequence of each cluster thereby annotating biomolecular sequences.
    Type: Application
    Filed: April 23, 2010
    Publication date: July 28, 2011
    Applicant: Compugen Ltd.
    Inventors: Liat Mintz, Hanqing Xie, Dvir Dahary, Erez Levanon, Shiri Freilich, Nili Beck, Wei-Yong Zhu, Alon Wasserman, Jeanne Bernstein
  • Publication number: 20110177998
    Abstract: Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
    Type: Application
    Filed: July 11, 2008
    Publication date: July 21, 2011
    Inventors: Ronen Shemesh, Zurit Levine, Amir Toporik, Chen Hermesh, Yossef Kliger, Eyal Gofer, Assaf Wool, Dvir Dahary, Yossi Cohen
  • Patent number: 7939634
    Abstract: Novel polypeptides and polynucleotides encoding same are provided. Also provided methods and pharmaceutical compositions which can be used to treat various disorders such as cancer, immunological-related, blood-related and skin-related disorders using the polypeptides and polynucleotides of the present invention. Also provided are methods and kits for diagnosing, determining predisposition and/or prognosis of various disorders using as diagnostic markers the novel polypeptides and polynucleotides of the present invention.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: May 10, 2011
    Assignee: Compugen Ltd.
    Inventors: Michal Ayalon-Soffer, Zurit Levine, Osnat Sella-Tavor, Alex Diber, Ronen Shemesh, Amir Toporik, Galit Rotman, Sergey Nemzer, Avi Rosenberg, Dvir Dahary, Assaf Wool, Gad S. Cojocaru, Pinchas Akiva, Sarah Pollock, Kinneret Savitsky, Jeanne Bernstein
  • Publication number: 20110104217
    Abstract: Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
    Type: Application
    Filed: December 14, 2010
    Publication date: May 5, 2011
    Inventors: Yossi Cohen, Ronen Shemesh, Amir Toporik, Zurit Levine, Assaf Wool, Dvir Dahary, Iris Hecht, Galit Rotman, Michal Ayalon-Soffer
  • Publication number: 20110091454
    Abstract: Polypeptide sequences and polynucleotide sequences are provided. Also provided are annotative information concerning such sequences and uses for these sequences.
    Type: Application
    Filed: February 8, 2010
    Publication date: April 21, 2011
    Inventors: Alex Diber, Sarah Pollock, Zurit Levine, Sergey Nemzer, Vladimir Grebinskiy, Brian Meloon, Andrew Olson, Avi Rosenberg, Ami Haviv, Shaul Zevin, Tomer Zekharia, Zipi Shaked, Moshe Olshansky, Ariel Farkash, Eyal Privman, Amit Novik, Naomi Keren, Gad S. Cojocaru, Pinchas Akiva, Yossi Cohen, Ronen Shemesh, Osnat Sella-Tavor, Liat Mintz, Hanqing Xie, Dvir Dahary, Erez Levanon, Shiri Freilich, Nili Beck, Wei-Yong Zhu, Alon Wasserman, Chen Chermesh, Idit Azar, Rotem Sorek, Jeanne Bernstein
  • Patent number: 7906635
    Abstract: Novel markers for ovarian cancer that are both sensitive and accurate. These markers are overexpressed and/or differentially expressed in ovarian cancer specifically, as opposed to normal ovarian tissue. The measurement of these markers, alone or in combination, in patient samples provides information that the diagnostician can correlate with a probable diagnosis, in ovarian cancer. The markers of the present invention, alone or in combination, show a high degree of differential detection between ovarian cancer and non-cancerous states.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: March 15, 2011
    Assignee: Compugen Ltd.
    Inventors: Gad S. Cojocaru, Sarah Pollock, Zurit Levine, Alexander Diber, Guy Kol, Amir Toporik, Rotem Sorek, Dvir Dahary, Michal Ayalon-Soffer, Pinchas Akiva, Amit Novik, Yossi Cohen, Osnat Sella-Tavor, Shira Walach, Shirley Sameah-Greenwald, Ronen Shemesh, Maxim Shklar
  • Patent number: 7884180
    Abstract: Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
    Type: Grant
    Filed: September 18, 2007
    Date of Patent: February 8, 2011
    Assignee: Compugen Ltd
    Inventors: Yossi Cohen, Ronen Shemesh, Amir Toporik, Zurit Levine, Assaf Wool, Dvir Dahary, Iris Hecht, Galit Rotman, Michal Ayalon-Soffer
  • Patent number: 7842459
    Abstract: Novel splice variant nucleic acid sequences. The novel splice variants and their nucleic acid sequences according to the present invention may optionally be used for diagnosis of a variant-detectable disease as described herein.
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: November 30, 2010
    Assignee: Compugen Ltd.
    Inventors: Michal Ayalon-Soffer, Sarah Pollock, Ronen Shemesh, Rotem Sorek, Zurit Levine, Zipi Shaqed, Amir Toporik, Gad S. Cojocaru, Dvir Dahary, Guy Kol, Pinchas Akiva, Amit Novik, Sergey Nemzer, Alexander Diber, Maxim Shklar, Osnat Sella-Tavor, Lily Bazak, Ariel Farkash, Yossi Cohen