Patents by Inventor E. Giuliano Frigerio

E. Giuliano Frigerio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Derivatives of biliary acids, process for the production thereof and corresponding pharmaceutical compositions
    Patent number: 4981983
    Abstract: New derivatives of chenodeoxycholic, ursodeoxy cholic, cholic and ursocholic acids, bearing a methyl group in the side chain in an alfa position to the carboxylic group, the corresponding nor- and di-nor- derivatives, and the corresponding conjugates with taurine and glycine, are described.The compounds of the invention are prepared by methylation of the esters with methyl iodide in the presence of lithium-dialkylamides.
    Type: Grant
    Filed: October 2, 1989
    Date of Patent: January 1, 1991
    Assignee: Gipharmex S.p.A.
    Inventors: Virginio Castagnola, E. Giuliano Frigerio, Roberto Pellicciari, Aldo Roda
  • Derivatives of biliary acids, process for the production thereof and corresponding pharmaceutical compositions
    Patent number: 4892868
    Abstract: New derivatives of chenodeoxycholic, ursodeoxycholic, cholic and ursocholic acids, bearing a methyl group in the side chain, in an alfa position to the carboxylic group, the corresponding nor- and di-nor- derivatives, and the corresponding conjugates with taurine and glycine, are described.The compounds of the invention are prepared by methylation of the esters with methyl iodide in the presence of lithium-dialkylamides.
    Type: Grant
    Filed: July 10, 1986
    Date of Patent: January 9, 1990
    Assignee: Gipharmex, S.p.A.
    Inventors: Virginio Castagnola, E. Giuliano Frigerio, Roberto Pellicciari, Aldo Roda
  • Derivatives of biliary acids, process for the production thereof and pharmaceutical compositions containing the same
    Patent number: 4565810
    Abstract: New derivatives of chenodeoxycholic, ursodeoxycholic, cholic and ursocholic bile acids having in the side chain in the 19 position a cyclopropane ring are described together with taurine and glycine conjugated derivatives thereof.The compounds of the invention, prepared from suitable olephinic intermediates by reaction with alkyl diazoacetates or by Simmons-Smith reaction and optional conjugation with taurine or glycine, are endowed with interesting therapeutic properties.
    Type: Grant
    Filed: April 24, 1984
    Date of Patent: January 21, 1986
    Assignee: Lehner A.G.
    Inventors: Virginio Castagnola, E. Giuliano Frigerio, Roberto Pellicciari