Patents by Inventor Eckhardt S. Ferdinandi

Eckhardt S. Ferdinandi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • N-[[6 -methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]-N-methylglycin e S-oxide and the amide thereof
    Patent number: 4994381
    Abstract: Disclosed herein are N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxmethyl]-N-methylgly cine S-oxide (tolrestat S-oxide) and the amine thereof and methods of their preparation. The S-oxides are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.
    Type: Grant
    Filed: March 20, 1989
    Date of Patent: February 19, 1991
    Assignee: American Home Products Corporation
    Inventors: Eckhardt S. Ferdinandi, Michael S. Malamas, Kazimir Sestanj, Surendra N. Sehgal
  • N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]-N-methylg lycine S-oxide and the amide thereof
    Patent number: 4853484
    Abstract: Disclosed herein are N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylgly cine S-oxide (tolrestat S-oxide) and the amide thereof and methods of their preparation. The S-oxides are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.
    Type: Grant
    Filed: October 28, 1987
    Date of Patent: August 1, 1989
    Assignee: American Home Products Corporation
    Inventors: Eckhardt S. Ferdinandi, Michael S. Malamas, Kazimir Sestanj, Surendra N. Sehgal
  • Substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids
    Patent number: 4748252
    Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at position 8. The derivatives are useful anti-inflammatory and analgesic agents and methods and chemical intermediates for their preparation are also disclosed.
    Type: Grant
    Filed: January 28, 1987
    Date of Patent: May 31, 1988
    Assignee: American Home Products Corporation
    Inventors: Eckhardt S. Ferdinandi, Dominick Mobilio, Joseph P. Sabatucci, Leslie G. Humber
  • N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxome thyl]-N-methylglycine S-oxide and the amide thereof
    Patent number: 4734435
    Abstract: Disclosed herein are N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]-N-methylgl ycine S-oxide (tolrestat S-oxide) and the amide thereof and methods of their preparation. The S-oxides are new aldose reductase inhibitors useful for the treatment of prevention of diabetic complications.
    Type: Grant
    Filed: November 25, 1986
    Date of Patent: March 29, 1988
    Assignee: American Home Products Corp.
    Inventors: Eckhardt S. Ferdinandi, Michael S. Malamas, Kazimir Sestanj, Surendra N. Sehgal
  • Substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids
    Patent number: 4686213
    Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at position 8. The derivatives are useful anti-inflammatory and analgesic agents and methods and chemical intermediates for their preparation are also disclosed. Included are compounds of the formula ##STR1## wherein R.sup.1 is --H or lower alkyl containing 1 to 3 carbon atoms; R.sup.2 is --NH.sub.2, --NHCHO, --NHCONH.sub.2, --OCH.sub.3, oxo; R.sup.3 is --H or lower alkyl containing 1 to 3 carbon atoms and the pharmaceutically acceptable salts thereof when R.sup.1 is --H.
    Type: Grant
    Filed: August 15, 1986
    Date of Patent: August 11, 1987
    Assignee: American Home Products Corporation
    Inventors: Eckhardt S. Ferdinandi, Dominick Mobilio, Joseph P. Sabatucci, Leslie G. Humber
  • N-[[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]-thioxomethyl and carbonyl]-N-methylglycinamides
    Patent number: 4672059
    Abstract: Disclosed herein are tolrestat and oxotolrestat amides and methods of preparation. The amides are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.
    Type: Grant
    Filed: November 18, 1985
    Date of Patent: June 9, 1987
    Assignee: American Home Products Corporation
    Inventors: Kazimir Sestanj, Eckhardt S. Ferdinandi