Patents by Inventor Edgardo Baracchini

Edgardo Baracchini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oligonucleotide modulation of multidrug resistance-associated protein
    Patent number: 5807838
    Abstract: Compositions and methods are provided for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of the synthesis or metabolism of multidrug resistance-associated protein (MRP) . In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding multidrug resistance-associated protein (MRP). Methods of treating animals suffering from diseases or conditions amenable to therapeutic intervention by modulating multidrug resistance with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to multidrug resistance-associated protein (MRP) are disclosed. Methods of preventing the development of multidrug resistance and of improving the efficacy of chemotherapy are also disclosed.
    Type: Grant
    Filed: April 16, 1996
    Date of Patent: September 15, 1998
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Edgardo Baracchini, Jr., Clarence Frank Bennett
  • Antisense oligonucleotide modulation of multidrug resistance-associated protein
    Patent number: 5801154
    Abstract: Compositions and methods are provided for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of the synthesis or metabolism of multidrug resistance-associated protein (MRP). In accordance with referred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding MRP. In a preferred embodiment, the oligonucleotide has at least one 2'-methoxyethoxy modification. Methods of preventing the development of multidrug resistance and of improving the efficacy of chemotherapy are also disclosed.
    Type: Grant
    Filed: April 8, 1997
    Date of Patent: September 1, 1998
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Edgardo Baracchini, C. Frank Bennett, Nicholas M. Dean
  • Oligonucleotide modulation of multidrug resistance-associated protein
    Patent number: 5510239
    Abstract: Compositions and methods are provided for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of the synthesis or metabolism of multidrug resistance-associated protein (MRP). In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding multidrug resistance-associated protein (MRP). Methods of treating animals suffering from diseases or conditions amenable to therapeutic intervention by modulating multidrug resistance with an oligonucleotides specifically hybridizable with RNA or DNA corresponding to multidrug resistance-associated protein (MRP) are disclosed. Methods of preventing the development of multidrug resistance and of improving the efficacy of chemotherapy are also-disclosed.
    Type: Grant
    Filed: October 18, 1993
    Date of Patent: April 23, 1996
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Edgardo Baracchini, Jr., Clarence F. Bennett