Patents by Inventor Edvin Wilhelm Johannesen

Edvin Wilhelm Johannesen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Technetium labelled peptides
    Patent number: 9259496
    Abstract: The present invention relates to technetium imaging agents comprising radiolabeled c-Met binding peptides suitable for SPECT or PET imaging in vivo. The c-Met binding peptides are labelled via chelator conjugates. Also disclosed are pharmaceutical compositions, methods of preparation of the agents and compositions, plus methods of in vivo imaging using the compositions, especially for use in the diagnosis of cancer.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: February 16, 2016
    Assignee: GE Healthcare Limited
    Inventors: Peter Brian Iveson, Bard Indrevoll, Ben Newton, Rajiv Bhalla, Edvin Wilhelm Johannesen
  • TECHNETIUM LABELLED PEPTIDES
    Publication number: 20140004041
    Abstract: The present invention relates to technetium imaging agents comprising radiolabeled c-Met binding peptides suitable for SPECT or PET imaging in vivo. The c-Met binding peptides are labelled via chelator conjugates. Also disclosed are pharmaceutical compositions, methods of preparation of the agents and compositions, plus methods of in vivo imaging using the compositions, especially for use in the diagnosis of cancer.
    Type: Application
    Filed: March 2, 2012
    Publication date: January 2, 2014
    Applicant: GE HEALTHCARE LIMITED
    Inventors: Peter Brian Iveson, Bard Indrevoll, Ben Newton, Rajiv Bhalla, Edvin Wilhelm Johannesen
  • Peptide imaging agents
    Patent number: 8529874
    Abstract: The present invention relates to labelled cMet binding peptides suitable for optical imaging in vivo. The peptides are labelled with an optical reporter group suitable for imaging in the red to near-infrared region. Also disclosed are pharmaceutical compositions and kits, as well as in vivo imaging methods, especially of use in the detection, staging, diagnosis, monitoring of disease progression or monitoring of treatment of colorectal cancer (CRC).
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: September 10, 2013
    Assignee: GE Healthcare AS
    Inventors: Edvin Wilhelm Johannesen, Alan Cuthbertson
  • Peptide imaging agents
    Patent number: 8431111
    Abstract: The present invention relates to labelled cMet binding peptides suitable for optical imaging in vivo. The peptides are labelled with a benzopyrylium dye suitable for imaging in the red to near-infrared region. Also disclosed are pharmaceutical compositions and kits, as well as in vivo imaging methods, especially of use in the detection, staging, diagnosis, monitoring of disease progression or monitoring of treatment of colorectal cancer (CRC).
    Type: Grant
    Filed: July 29, 2008
    Date of Patent: April 30, 2013
    Assignee: GE Healthcare Limited
    Inventors: Robert James Domett Nairne, Andrew John Healey, Edvin Wilhelm Johannesen
  • OPTICAL IMAGING AGENTS
    Publication number: 20100303727
    Abstract: The present invention relates to imaging agents suitable for in vivo optical imaging, which comprise conjugates of pentamethine cyanine dyes having reduced non-specific binding, e.g. to plasma proteins. This is achieved by control of the nature and location of the sulfonic acid substituents, in particular the sulfoalkyl groups. Also disclosed are pharmaceutical compositions and kits, as well as in vivo imaging methods.
    Type: Application
    Filed: May 16, 2008
    Publication date: December 2, 2010
    Inventors: Alan Cuthertson, Edvin Wilhelm Johannesen, Michael Edward Cooper
  • PEPTIDE IMAGING AGENTS
    Publication number: 20100178253
    Abstract: The present invention relates to labelled cMet binding peptides suitable for optical imaging in vivo. The peptides are labelled with a benzopyrylium dye suitable for imaging in the red to near-infrared region. Also disclosed are pharmaceutical compositions and kits, as well as in vivo imaging methods, especially of use in the detection, staging, diagnosis, monitoring of disease progression or monitoring of treatment of colorectal cancer (CRC).
    Type: Application
    Filed: July 29, 2008
    Publication date: July 15, 2010
    Applicant: GE HEALTHCARE LIMITED
    Inventors: Robert James Domett Nairne, Andrew John Healey, Edvin Wilhelm Johannesen
  • PEPTIDE IMAGING AGENTS
    Publication number: 20100150843
    Abstract: The present invention relates to labelled cMet binding peptides suitable for optical imaging in vivo. The peptides are labelled with an optical reporter group suitable for imaging in the red to near-infrared region. Also disclosed are pharmaceutical compositions and kits, as well as in vivo imaging methods, especially of use in the detection, staging, diagnosis, monitoring of disease progression or monitoring of treatment of colorectal cancer (CRC).
    Type: Application
    Filed: May 16, 2008
    Publication date: June 17, 2010
    Inventors: Edvin Wilhelm Johannesen, Alan Cuthbertson
  • Optical Imaging Contrast Agents
    Publication number: 20080206141
    Abstract: The invention relates to optical imaging contrast agents. More specifically the invention relates to optical imaging activatable contrast agent for use in diagnosis and for monitoring the effect of treatment. The contrast agent employs a combined targeting and activation approach and comprises a target binding ligand (V), an enzyme cleavable group (E), a fluorophore (D) and a quencher agent (Q) covalently linked in one molecule.
    Type: Application
    Filed: July 10, 2006
    Publication date: August 28, 2008
    Inventor: Edvin Wilhelm Johannesen