Abstract: The present disclosure provides compositions comprising an opsin polypeptide and an arrestin polypeptide and their use thereof. Exemplary embodiments provide a composition including an opsin polypeptide, or an opsin polypeptide and an arrestin polypeptide, wherein at least one of the opsin or arrestin polypeptide comprises at least one mutation that increases a temporal resolution of the opsin polypeptide’s response to light. The opsin polypeptide and the arrestin polypeptide can be operably linked or separate. Additionally, use of said compositions for restoring retinal photosensitivity or treating a retinal degenerative condition is also provided.

Abstract: The present invention relates to a resin composition for preparing foamed rigid polymer products, comprising at least one polymer resin, a surface-treated calcium carbonate having a weight median particle diameter d50 of between 0.1 ?m and 1 ?m, measured according to the sedimentation method, in an amount of at least 10 parts per hundred parts of the at least one polymer resin (phr) and a blowing agent in an amount of less than 1 phr, to a foamed rigid polymer product prepared from the composition, to a method for preparing a foamed rigid polymer product as well as to the use of a calcium carbonate for reducing the density of a foamed rigid polymer product.

Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof and N-oxides thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds and the uses of such compounds for the treatment of D1-mediated (or D1-associated) disorders including cognitive and motivational impairments and negative symptoms associated with illnesses such as schizophrenia, depression, bipolar disorder, Parkinson's disease, Mild cognitive impairment (MCI), Alzheimer's disease, lupus, Huntington's disease, Parkinson's, dyskinesia, ADHD, post-traumatic stress disorder, autism spectrum disorder, treatment-resistant depression, major depressive disorder (MDD), drug dependence, Tourette's syndrome, tardive dyskinesias as well as impairments associated with age, chronic stress, sleep deprivation, combat, chronic fatigue; endocrine or metabolic diseases such as hyperglycemia, dislipidemia, diabetes, obesity, and sepsis; and c

Abstract: A technique for cloud infrastructure backup in a virtualized environment utilizing shared storage includes obtaining a workload input/output (I/O) profile to the shared storage over a time period. An attempt to locate one or more time windows in the workload I/O profile for which a cloud infrastructure backup can be staged is initiated. In response to determining the cloud infrastructure backup can be staged during at least one of the time windows, staging of the cloud infrastructure backup is scheduled during a selected one of the time windows. In response to determining the cloud infrastructure backup cannot be staged during at least one of the time windows, an interference tolerance approach is employed for accessing the shared storage for active workloads and the cloud infrastructure backup during the staging of the cloud infrastructure backup.

Abstract: A technique for cloud infrastructure backup in a virtualized environment utilizing shared storage includes obtaining a workload input/output (I/O) profile to the shared storage over a time period. An attempt to locate one or more time windows in the workload I/O profile for which a cloud infrastructure backup can be staged is initiated. In response to determining the cloud infrastructure backup can be staged during at least one of the time windows, staging of the cloud infrastructure backup is scheduled during a selected one of the time windows. In response to determining the cloud infrastructure backup cannot be staged during at least one of the time windows, an interference tolerance approach is employed for accessing the shared storage for active workloads and the cloud infrastructure backup during the staging of the cloud infrastructure backup.

Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof and N-oxides thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds (N-oxides thereof or or pharmaceutically acceptable salts of the compound or the N-oxides) and the uses of such compounds (N-oxides thereof or or pharmaceutically acceptable salts of the compound or the N-oxides) for the treatment of D1-mediated (or D1-associated) disorders including cognitive and motivational impairments and negative symptoms associated with illnesses such as schizophrenia, depression, bipolar disorder, Parkinson's disease, Mild cognitive impairment (MCI), Alzheimer's disease, lupus, Huntington's disease, Parkinson's, dyskinesia, ADHD, post-traumatic stress disorder, autism spectrum disorder, treatment-resistant depression, major depressive disorder (MDD), drug dependence, Tourette's syndrome, tardive dyskinesias as well as impairments asso

Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof and N-oxides thereof; processes and intermediates for preparation of; and compositions and uses thereof. The present invention further provides D1 agonists with reduced D1R desensitization, D1 agonists with a reduced ?-arrestin recruitment activity relative to Dopamine, D1 agonists interacting significantly with the Ser188 but not significantly with the Ser202 of a D1R when binding to the D1R, D1 agonists interacting less strongly with the Asp103 and interacting less strongly with the Ser198 of a D1R when binding to the D1R, and their uses.

Abstract: A marine vessel towing assembly includes a tow pin assembly housing including therein a self-contained horizontal roller cartridge, a self-contained vertical pin cartridge, and a self-contained hook cartridge, the tow pin assembly housing defining a clear path of removal for each self-contained cartridge from the tow pin assembly housing such that removal of each self-contained cartridge is conducted with an absence of contact with remaining self-contained cartridges of the tow pin assembly housing.

Abstract: A marine vessel towing assembly includes a tow pin assembly housing including therein a self-contained horizontal roller cartridge, a self-contained vertical pin cartridge, and a self-contained hook cartridge, the tow pin assembly housing defining a clear path of removal for each self-contained cartridge from the tow pin assembly housing such that removal of each self-contained cartridge is conducted with an absence of contact with remaining self-contained cartridges of the tow pin assembly housing.

Abstract: A technique for cloud infrastructure backup in a virtualized environment utilizing shared storage includes obtaining a workload input/output (I/O) profile to the shared storage over a time period. An attempt to locate one or more time windows in the workload I/O profile for which a cloud infrastructure backup can be staged is initiated. In response to determining the cloud infrastructure backup can be staged during at least one of the time windows, staging of the cloud infrastructure backup is scheduled during a selected one of the time windows. In response to determining the cloud infrastructure backup cannot be staged during at least one of the time windows, an interference tolerance approach is employed for accessing the shared storage for active workloads and the cloud infrastructure backup during the staging of the cloud infrastructure backup.

Abstract: A technique for cloud infrastructure backup in a virtualized environment utilizing shared storage includes obtaining a workload input/output (I/O) profile to the shared storage over a time period. An attempt to locate one or more time windows in the workload I/O profile for which a cloud infrastructure backup can be staged is initiated. In response to determining the cloud infrastructure backup can be staged during at least one of the time windows, staging of the cloud infrastructure backup is scheduled during a selected one of the time windows. In response to determining the cloud infrastructure backup cannot be staged during at least one of the time windows, an interference tolerance approach is employed for accessing the shared storage for active workloads and the cloud infrastructure backup during the staging of the cloud infrastructure backup.

Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof and N-oxides thereof; processes and intermediates for preparation of; and compositions and uses thereof. The present invention further provides D1 agonists with reduced D1R desensitization, D1 agonists with a reduced ?-arrestin recruitment activity relative to Dopamine, D1 agonists interacting significantly with the Ser188 but not significantly with the Ser202 of a D1R when binding to the D1R, D1 agonists interacting less strongly with the Asp103 and interacting less strongly with the Ser198 of a D1R when binding to the D1R, and their uses.

Abstract: The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof and N-oxides thereof; processes and intermediates for preparation of; and compositions and uses thereof. The present invention further provides D1 agonists with reduced D1R desensitization, D1 agonists with a reduced ?-arrestin recruitment activity relative to Dopamine, D1 agonists interacting significantly with the Ser188 but not significantly with the Ser202 of a D1R when binding to the D1R, D1 agonists interacting less strongly with the Asp103 and interacting less strongly with the Ser198 of a D1R when binding to the D1R, and their uses.

Abstract: A method for conducting encrypted communication in a network and a network having a plurality of nodes organized into a plurality of groups which initiates encrypted communication between a first one of the plurality of nodes of a first one of the plurality of groups and a second one of the plurality of nodes of the first one of the plurality of groups different from the first one of the plurality of groups using a group key and initiates encrypted communication between a third one of the plurality of nodes of the first one of the plurality of groups and a fourth one of the plurality of nodes of a second one of the plurality groups different from the first one of the plurality of groups using a session key.

Abstract: The present invention relates to a resin composition for preparing foamed rigid polymer products, comprising at least one polymer resin, a surface-treated calcium carbonate having a weight median particle diameter d50 of between 0.1 ?m and 1 ?m, measured according to the sedimentation method, in an amount of at least 10 parts per hundred parts of the at least one polymer resin (phr) and a blowing agent in an amount of less than 1 phr, to a foamed rigid polymer product prepared from the composition, to a method for preparing a foamed rigid polymer product as well as to the use of a calcium carbonate for reducing the density of a foamed rigid polymer product.

Abstract: A method for conducting encrypted communication in a network and a network having a plurality of nodes organized into a plurality of groups which initiates encrypted communication between a first one of the plurality of nodes of a first one of the plurality of groups and a second one of the plurality of nodes of the first one of the plurality of groups different from the first one of the plurality of groups using a group key and initiates encrypted communication between a third one of the plurality of nodes of the first one of the plurality of groups and a fourth one of the plurality of nodes of a second one of the plurality groups different from the first one of the plurality of groups using a session key.

Abstract: An image processing method includes wavefront coding a wavefront that forms an optical image, converting the optical image to a data stream and processing the data stream with a color-specific filter kernel to reverse effects of wavefront coding and generate a final image. Another image processing method includes wavefront coding a wavefront that forms an optical image, converting the optical image to a data stream and colorspace converting the data stream. The method separates spatial information and color information of the colorspace converted data stream into one or more separate channels and deblurs one or both of the spatial information and the color information. The method recombines the channels to recombine deblurred spatial information with deblurred color information, and colorspace converts the recombined deblurred spatial and color information to generate an output image.

Abstract: A biometric optical recognition system includes optics, including a wavefront coding mask, for imaging a wavefront of object to be recognized to an intermediate image, and a detector for detecting the intermediate image. A modulation transfer function detected by the detector contains no zeros such that subsequent task based image processing recognizes the object. A biometric recognition system includes optics for imaging a wavefront of an object to be recognized to a first intermediate image, and a detector for detecting the first intermediate image. The optics include a phase changing element configured for modifying the wavefront such that a modulation transfer function characterizing detection of the first intermediate image contains no zeros such that subsequent task based image processing recognizes the object.

Abstract: Systems and methods for generating an optical image include forming an optical image with at least one optical element of an optical imager while modifying wavefront phase. Modifying the phase does not reduce an optical bandpass limited by an aperture of the optical imager. The systems and methods also include detecting the optical image over a range of spatial frequencies such that there are no zeros in an optical transfer function of the optical imager over detected spatial frequencies within the optical bandpass and over an extended depth of focus that is larger than a depth of focus occurring without modifying wavefront phase.

Abstract: An image processing system includes a wavefront coding element that codes a wavefront forming an optical image, a detector for converting the optical image to a data stream and an image processor for processing the data stream with a reduced set filter kernel to reverse effects of wavefront coding and generate a final image. The reduced set filter kernel may include a reduced set distributive filter kernel. An image processing method includes wavefront coding a wavefront that forms an optical image, converting the optical image to a data stream, and processing the data stream with a reduced set filter kernel to reverse effects of wavefront coding and generate a final image. The processing consists of processing the image, for each pixel, with filter tap logic consisting of a shifter.