Patents by Inventor Edward B. McCauley

Edward B. McCauley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10886118
    Abstract: A magnet assembly for an ion source comprising a first magnet of a first magnet type; a second magnet of a second magnet type; a heat shield located between the first magnet and the second magnet; and a heat sink coupled to the heat shield; wherein the first magnet type having a higher Curie temperature than the second magnet type.
    Type: Grant
    Filed: October 1, 2019
    Date of Patent: January 5, 2021
    Assignee: Thermo Finnigan LLC
    Inventors: Edward B. McCauley, Deven L. Shinholt
  • Patent number: 10755914
    Abstract: A multipole assembly configured to be disposed in a mass spectrometer includes a plurality of elongate electrodes arranged about an axis extending along a longitudinal trajectory of the plurality of elongate electrodes and configured to confine ions radially about the axis, and a piezoelectric actuator configured to adjust a position of a first electrode included in the plurality of elongate electrodes.
    Type: Grant
    Filed: December 5, 2019
    Date of Patent: August 25, 2020
    Assignee: Thermo Finnigan LLC
    Inventors: Edward B. McCauley, Scott T. Quarmby, George B. Guckenberger, James M. Hitchcock
  • Patent number: 10672597
    Abstract: An ion detector includes a first stage dynode configured to receive an ion beam and generate electrons, a photon source arranged to provide photons to the first stage dynode, the photons of sufficient energy to cause the first stage dynode to emit photoelectrons, an electron multiplier configured to receive the electrons or the photoelectrons from the first stage dynode and generate an output proportional to the number of electrons or photoelectrons, and a controller. The controller is configured to receive the output generated in response to the photoelectrons; calculate a gain curve of the detector based on the output; and set a voltage of the electron multiplier or the first stage dynode to achieve a target gain for the ion beam.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: June 2, 2020
    Assignee: THERMO FINNIGAN LLC
    Inventors: Joshua T. Maze, Edward B. McCauley, Scott T. Quarmby
  • Patent number: 10648956
    Abstract: A capillary column includes a fused silica tubing and a polyimide coating over the fusing silica tubing. Additionally, the capillary column further includes a first plurality of integrated ferrules positioned along at least a first portion of the fused silica tubing and spaced apart from one another by a first fixed interval.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: May 12, 2020
    Assignee: THERMO FINNIGAN LLC
    Inventor: Edward B. McCauley
  • Publication number: 20200111657
    Abstract: A multipole assembly configured to be disposed in a mass spectrometer includes a plurality of elongate electrodes arranged about an axis extending along a longitudinal trajectory of the plurality of elongate electrodes and configured to confine ions radially about the axis, and a piezoelectric actuator configured to adjust a position of a first electrode included in the plurality of elongate electrodes.
    Type: Application
    Filed: December 5, 2019
    Publication date: April 9, 2020
    Inventors: Edward B. McCAULEY, Scott T. QUARMBY, George B. GUCKENBERGER, James M. HITCHCOCK
  • Patent number: 10600626
    Abstract: A calibration device and a method of calibrating a mass spectrometer are described where two or more immiscible mass spectrometry calibration compounds in close proximity to each other share a common headspace volume above their liquid surfaces. This arrangement allows each calibrant to evaporate at differing rates while allowing the headspace concentrations to remain relatively unchanged over time (forming a quasi-equilibrium calibrant mixture). The mixture is either delivered to an ion source of a mass spectrometer or to a vacuum pump via a flow restrictor from a calibration vial. The calibrant gas mixture in the headspace volume may be used to calibrate a mass spectrometer.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: March 24, 2020
    Assignee: THERMOS FINNIGAN LLC
    Inventors: Jason S. Cole, Edward B. McCauley
  • Patent number: 10598641
    Abstract: A method of assessing the linearity and dynamic range of a mass spectrometer is described comprising analyzing two or more test standards containing positional isomers, for example, using a series of N isomeric analytes with or without an internal standard where N is an integer from 2 to 6 inclusive. The concentrations of the N isomeric analytes may or may not be interleaved between two or more standards. The method allows for repeated instrument characterization without having many of the problems associated with using only a single standard such as octafluoronaphthalene (OFN), for example, persistence, and it may lessen sample carryover issues between adjacent samples. Methods are described using positional isomers of dibromodifluorobenzene in various configurations that show an improved means for qualitative and quantitative analysis of one or more analytes by GC-MS.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: March 24, 2020
    Assignee: THERMO FINNIGAN LLC
    Inventors: Edward B. McCauley, Scott T. Quarmby
  • Patent number: 10585072
    Abstract: A capillary column includes a fused silica tubing, a polyimide coating over the fusing silica tubing, and a first plurality of integrated ferrules positioned along at least a first portion of the fused silica tubing and spaced apart from one another by a first fixed interval. Each of the first plurality of integrated ferrules includes a first deformable surface and a second deformable surface. The first plurality of integrated ferrules are secured to the column through deformation of the first deformable surface and the second deformable surface is configured to form a seal with a junction when secured with a nut.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: March 10, 2020
    Assignee: THERMO FINNIGAN LLC
    Inventor: Edward B. McCauley
  • Patent number: 10566180
    Abstract: A multipole assembly configured to be disposed in a mass spectrometer includes a plurality of elongate electrodes arranged about an axis extending along a longitudinal trajectory of the plurality of elongate electrodes and configured to confine ions radially about the axis, and a piezoelectric actuator configured to adjust a position of a first electrode included in the plurality of elongate electrodes.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: February 18, 2020
    Assignee: THERMO FINNIGAN LLC
    Inventors: Edward B. McCauley, Scott T. Quarmby, George B. Guckenberger, James M. Hitchcock
  • Publication number: 20200020518
    Abstract: A multipole assembly configured to be disposed in a mass spectrometer includes a plurality of elongate electrodes arranged about an axis extending along a longitudinal trajectory of the plurality of elongate electrodes and configured to confine ions radially about the axis, and a piezoelectric actuator configured to adjust a position of a first electrode included in the plurality of elongate electrodes.
    Type: Application
    Filed: July 11, 2018
    Publication date: January 16, 2020
    Inventors: Edward B. McCAULEY, Scott T. QUARMBY, George B. GUCKENBERGER, James M. HITCHCOCK
  • Publication number: 20200020513
    Abstract: An ion detector includes a first stage dynode configured to receive an ion beam and generate electrons, a photon source arranged to provide photons to the first stage dynode, the photons of sufficient energy to cause the first stage dynode to emit photoelectrons, an electron multiplier configured to receive the electrons or the photoelectrons from the first stage dynode and generate an output proportional to the number of electrons or photoelectrons, and a controller. The controller is configured to receive the output generated in response to the photoelectrons; calculate a gain curve of the detector based on the output; and set a voltage of the electron multiplier or the first stage dynode to achieve a target gain for the ion beam.
    Type: Application
    Filed: July 11, 2018
    Publication date: January 16, 2020
    Inventors: Joshua T. MAZE, Edward B. McCAULEY, Scott T. QUARMBY
  • Patent number: 10529550
    Abstract: A multipole assembly configured to be disposed in a mass spectrometer includes a plurality of elongate electrodes arranged about an axis extending along a longitudinal trajectory of the plurality of elongate electrodes and configured to confine ions radially about the axis, and a piezoelectric actuator configured to adjust a position of a first electrode included in the plurality of elongate electrodes.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: January 7, 2020
    Assignee: THERMO FINNIGAN LLC
    Inventors: Edward B. McCauley, Scott T. Quarmby, George B. Guckenberger, James M. Hitchcock
  • Patent number: 10490396
    Abstract: A magnet assembly for an ion source comprising a first magnet of a first magnet type; a second magnet of a second magnet type; a heat shield located between the first magnet and the second magnet; and a heat sink coupled to the heat shield; wherein the first magnet type having a higher Curie temperature than the second magnet type.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: November 26, 2019
    Assignee: Thermo Finnigan LLC
    Inventors: Edward B. McCauley, Deven L. Shinholt
  • Publication number: 20190195843
    Abstract: A method of assessing the linearity and dynamic range of a mass spectrometer is described comprising analyzing two or more test standards containing positional isomers, for example, using a series of N isomeric analytes with or without an internal standard where N is an integer from 2 to 6 inclusive. The concentrations of the N isomeric analytes may or may not be interleaved between two or more standards. The method allows for repeated instrument characterization without having many of the problems associated with using only a single standard such as octafluoronaphthalene (OFN), for example, persistence, and it may lessen sample carryover issues between adjacent samples. Methods are described using positional isomers of dibromodifluorobenzene in various configurations that show an improved means for qualitative and quantitative analysis of one or more analytes by GC-MS.
    Type: Application
    Filed: December 17, 2018
    Publication date: June 27, 2019
    Inventors: Edward B. McCAULEY, Scott T. QUARMBY
  • Publication number: 20190120801
    Abstract: A capillary column includes a fused silica tubing and a polyimide coating over the fusing silica tubing. Additionally, the capillary column further includes a first plurality of integrated ferrules positioned along at least a first portion of the fused silica tubing and spaced apart from one another by a first fixed interval.
    Type: Application
    Filed: December 14, 2018
    Publication date: April 25, 2019
    Inventor: Edward B. McCauley
  • Patent number: 10229825
    Abstract: A mass spectrometer system can include an ion source, a vacuum chamber; a mass analyzer within the vacuum chamber, a transfer tube between the ion source and the vacuum chamber, a transfer tube heater, and a vacuum pump. The mass spectrometer system can be configured to reduce the pump speed of the vacuum pump in response to receiving a transfer tube swap instruction; lower the temperature of the transfer tube to below a first threshold; operating the vacuum pump at the reduced pump speed while the transfer tube is replaced with a second transfer tube; heating the second transfer tube to a temperature above a pump down temperature; and increasing the pump speed of the vacuum pump after the temperature of the second transfer tube exceeds a second threshold.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: March 12, 2019
    Assignee: THERMO FINNIGAN LLC
    Inventors: Scott T. Quarmby, Edward B. McCauley, Joshua T. Maze
  • Patent number: 10184922
    Abstract: A capillary column includes a fused silica tubing and a polyimide coating over the fusing silica tubing. Additionally, the capillary column further includes a first plurality of integrated ferrules positioned along at least a first portion of the fused silica tubing and spaced apart from one another by a first fixed interval.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: January 22, 2019
    Assignee: Thermo Finnigan LLC
    Inventor: Edward B. McCauley
  • Publication number: 20180364204
    Abstract: A capillary column includes a fused silica tubing, a polyimide coating over the fusing silica tubing, and a first plurality of integrated ferrules positioned along at least a first portion of the fused silica tubing and spaced apart from one another by a first fixed interval. Each of the first plurality of integrated ferrules includes a first deformable surface and a second deformable surface. The first plurality of integrated ferrules are secured to the column through deformation of the first deformable surface and the second deformable surface is configured to form a seal with a junction when secured with a nut.
    Type: Application
    Filed: August 27, 2018
    Publication date: December 20, 2018
    Inventor: Edward B. McCAULEY
  • Publication number: 20180301329
    Abstract: A mass spectrometer system can include an ion source, a vacuum chamber; a mass analyzer within the vacuum chamber, a transfer tube between the ion source and the vacuum chamber, a transfer tube heater, and a vacuum pump. The mass spectrometer system can be configured to reduce the pump speed of the vacuum pump in response to receiving a transfer tube swap instruction; lower the temperature of the transfer tube to below a first threshold; operating the vacuum pump at the reduced pump speed while the transfer tube is replaced with a second transfer tube; heating the second transfer tube to a temperature above a pump down temperature; and increasing the pump speed of the vacuum pump after the temperature of the second transfer tube exceeds a second threshold.
    Type: Application
    Filed: June 22, 2018
    Publication date: October 18, 2018
    Inventors: Scott T. QUARMBY, Edward B. McCAULEY, Joshua T. MAZE
  • Publication number: 20180286656
    Abstract: A mass spectrometer system includes an ion source and a controller. The ion source includes a body having a length along a source axis from the first end to the second end; an electron source positioned at the first end and configured for accelerating an electron beam through the ionization chamber along the source axis. The controller is configured to operate the ion source in a high robustness mode by setting a second lens voltage and a filament voltage to minimize electron reflection back along the source axis towards the electron source; and operate the ion source in a high sensitivity mode by setting second lens voltage and a filament voltage to cause electron reflection back along the source axis towards the electron source.
    Type: Application
    Filed: March 26, 2018
    Publication date: October 4, 2018
    Inventor: Edward B. McCAULEY