Patents by Inventor Edward D. Huguenel

Edward D. Huguenel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5348855
    Abstract: A method for detecting (i) one or more microorganisms or (ii) nucleic acid sequences from a prokaryotic source or an eukaroytic source in an unpurified nucleic acid-containing test sample comprising(a) labeling the nucleic acids in the test sample,(b) contacting, under hybridization conditions, the labeled hybridizable nucleic acid and one or more immobilized hybridizable nucleic acid probes comprising (i) one or more known microorganisms or (ii) sequences from eukaroytic or prokaryotic sources, to form hybridized labeled nucleic acids, and(d) assaying for the hybridized nucleic acids by detecting the label. The method can be used to detect genetic disorders, e.g., sickle-cell anemia.
    Type: Grant
    Filed: October 4, 1991
    Date of Patent: September 20, 1994
    Assignee: Miles Inc.
    Inventors: Nanibhushan Dattagupta, Peter M. M. Rae, Daniel U. Rabin, Edward D. Huguenel
  • Patent number: 5308753
    Abstract: Methods for purifying and detecting IgM antibodies employ binding substances which are Borellia burgdorferi cells, or cellular or extracellular components obtained or derived therefrom and which bind to this class of antibodies. The binding substances may be attached to a solid substrate and then the substrate contacted with a solution containing IgM antibodies under conditions such that the antibodies bind to the binding substance on the substrate. The substrate is then contacted with a solution that releases the IgM antibodies from the substrate and the antibodies are recovered or detected. Applications of these methods include, for example, assays for diagnosing diseases which elicit primary and/or secondary IgM antibody-mediated immunity.
    Type: Grant
    Filed: February 20, 1992
    Date of Patent: May 3, 1994
    Assignee: The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: David W. Dorward, Edward D. Huguenel, Gary Davis, Claude F. Garon
  • Patent number: 5166053
    Abstract: A method for determining the adequacy of a cervical or urethral test specimen collected for an immunological assay to detect the presence of Chlamydia trachomatis. Cells present in the specimen are disrupted to expose a substance present in or on C. triachomatis that is detectable by immunological reaction. In order to determine if the test specimen contains an adequate amount of the cervical or urethral cell type that serves as a host cell for C. trachomatis, the disrupted specimen is also reacted with an immunological reagent that produces a detectable complex upon specific binding with a substance present in or on columnar epithelial cells. The present invention therefore provides a control reaction that verifies the adequacy of the collected test specimen and thereby increases the confidence that a negative test result for the presence of Chlamydia indicates the absence of a C. trachomatis infection in the patient.
    Type: Grant
    Filed: February 23, 1990
    Date of Patent: November 24, 1992
    Assignee: Miles Inc.
    Inventors: Edward D. Huguenel, William J. Knowles