Abstract: Methods, compositions, and treatment protocols for treating ischemic wounds and inflammatory conditions in a patient. The treatment protocols comprise or consist of using a modified collagen gel (MCG) to promote healing of ischemic wounds and reduce inflammation at the wound site and in other inflammatory conditions. The modified collagen gel comprises generally a dispersion of collagens in an aqueous matrix comprising water and glycerine, where the amount of Type I collagen is greater than the amount of Type II and Type III collagens in the gel.

Abstract: Methods, compositions, and treatment protocols for treating ischemic wounds and inflammatory conditions in a patient. The treatment protocols comprise or consist of using a modified collagen gel (MCG) to promote healing of ischemic wounds and reduce inflammation at the wound site and in other inflammatory conditions. The modified collagen gel comprises generally a dispersion of collagens in an aqueous matrix comprising water and glycerine, where the amount of Type I collagen is greater than the amount of Type II and Type III collagens in the gel.

Abstract: Methods, compositions, and treatment protocols for treating ischemic wounds and inflammatory conditions in a patient. The treatment protocols comprise or consist of using a modified collagen gel (MCG) to promote healing of ischemic wounds and reduce inflammation at the wound site and in other inflammatory conditions. The modified collagen gel comprises generally a dispersion of collagens in an aqueous matrix comprising water and glycerine, where the amount of Type I collagen is greater than the amount of Type II and Type III collagens in the gel.

Abstract: Methods and compositions for modulating JNK activity and stimulating efferocytosis in a cell or patient are described. Therapeutic modified collagens comprising a plurality of proteins characterized by Table 1 for use as JNK modulators are also described.

Abstract: Methods, compositions, and treatment protocols for treating ischemic wounds and inflammatory conditions in a patient. The treatment protocols comprise or consist of using a modified collagen gel (MCG) to promote healing of ischemic wounds and reduce inflammation at the wound site and in other inflammatory conditions. The modified collagen gel comprises generally a dispersion of collagens in an aqueous matrix comprising water and glycerine, where the amount of Type I collagen is greater than the amount of Type II and Type III collagens in the gel.

Abstract: A gel-type adhesive composite bandage (10) is provided which can be used in the treatment of fungus-involved or discolored toe nails, or for general wound treatment. The bandage (10) includes a base (12) having a preformed recess (16), with a humectant-containing gel (18) within the recess (16). An adhesive-coated web (14) is applied over the base (12) and gel (18). The web (14) is strippable from the base (12) with the gel (18) adhered to the web (14). In the use, the web (14) is removed from the base (12), and the exposed gel (18) is applied directly to the affected toe mail or wound. The remaining portions of the adhesive-coated web (14) is then used to maintain the web (14) and gel (18) in place. The gel (18) preferably includes a polymeric matrix having a substantial quantity of water soluble humectant (for example, glycerin) entrapped within the matrix.

Abstract: An improved therapy member (10) for treatment of sprains, muscle aches and orthopaedic injuries is provided which is very flexible to permit the member to be placed in conforming relationship with a patient's limb or other body part, while also allowing effective hot or cold thermal therapy. The therapy member (10) preferably includes an internal bladder (12) having a fluid inlet (26) and a fluid outlet (28). The bladder (12) is substantially surrounded by a body of flexible, thermally conductive gel (32), the latter being encased within a flexible fabric-type sheath (34). An inlet/outlet fluid supply tubing assembly (16) is coupled with the bladder (12) in order to permit circulation of hot or cold fluid through the bladder (12) for therapy purposes. The gel (32) advantageously includes a water soluble humectant entrapped within a polyacrylamide matrix.

Abstract: Improved therapy members useful for treating of sprains, muscle aches, orthopedic and skin injuries such as burns and other wounds are provided which make use of a pliable, self-sustaining, moisture sorbing gel including a humectant such as glycerin entrapped within a synthetic resin polymer matrix (e.g., a matrix containing acrylic acid or acrylamide monomer moieties). In one preferred embodiment, a body of the gel is encased within heat and moisture-permeable stretch fabric, and securing ties or the like are provided to permit the composite to be conformed to a body part and held in place. In use, such therapy wraps are either heated (as in a microwave oven) or refrigerated, so as to provide appropriate thermal treatment; it has been found that the preferred gel of the invention retains its pliability and other physical properties over a very broad temperature range, such as -20.degree. to 305.degree. F., and therefore the wraps of the invention can be used in many treatment contexts.

Abstract: Starch-based superabsorbents are extended by blending with highly modified, low molecular weight starches. The dextrinized starches synergistically interact with the superabsorbents thereby permitting dilution without a commensurate reduction in the water absorbency. While the principal utility of the blends is the absorption of aqueous fluids, when hydrated they yield soft, smooth gels useful as high-quality thickening agents.

Abstract: Absorbent compositions comprising graft copolymers of starch are prepared by a simplified method of synthesis. By using a mixture of a nonionic acrylic monomer and an anionic sulfonic acid-substituted acrylic monomer, highly absorbent compositions are prepared without the need for an alkaline saponification step. These compositions are also characterized by their ability to absorb large amounts of aqueous fluids under highly acidic conditions.

Abstract: Absorbent compositions comprising graft copolymers of acrylonitrile and starch, or related polyhydroxy polymers, are prepared by improved methods of synthesis. Mixing the acrylonitrile with selected water-soluble acrylic comonomers enables unexpected improvements including reduction of the saponification time, total elimination of the base-saponification step, elimination of the starch gelatinization step, preparation of products which absorb large amounts of aqueous fluids under highly acidic conditions, and preparation of products which absorb over 5000 times their weight of deionized water.

Abstract: A simple and selective technique for the oxidation of thiols resulted in high yields of the corresponding disulfides. The reaction is tailored so that all byproducts are either volatile or insoluble and the end product recovered easily in essentially pure form.A nonexclusive, irrevocable, royalty-free license in the invention herein described, throughout the world for all purposes of the United States Government, with the power to grant sublicenses for such purposes, is hereby granted to the Government of the United States of America.