Abstract: Described herein are engineered nucleases comprising mutations in the cleavage domain (e.g., FokI or homologue thereof) and/or DNA binding domain (zinc finger protein, TALE, single guide RNA) such that on-target specificity is increased.

Abstract: A display may have a pixel array such as a liquid crystal pixel array. The pixel array may be illuminated with backlight illumination from a direct-lit backlight unit. The backlight unit may include an array of light-emitting diodes (LEDs) on a printed circuit board. The display may have a notch to accommodate an input-output component. Reflective layers may be included in the notch. The backlight may include a color conversion layer with a property that varies as a function of position. The light-emitting diodes may be covered by a slab of encapsulant with recesses in an upper surface.

Abstract: Devices and methods for mixing and preparing therapeutic pellets are described. In one aspect, the present disclosure may include a medical device for mixing and preparing pharmaceuticals. The medical device may include a body sized and shaped to be supported by a human hand. The body may be elastically flexible between a relaxed shape and a flexed shape. In the relaxed shape, the body may form a basin and may be shaped and sized to receive a vessel for mixing or forming the therapeutic pellets. In the flexed shape, the bowl may be configured for controlled pouring of the therapeutic pellets.

Abstract: Disclosed herein are compositions for linking DNA binding domains and cleavage domains (or cleavage half-domains) to form non-naturally occurring nucleases with alternative configurations. Also described are methods of making and using compositions comprising these linkers.

Abstract: Disclosed are methods and systems for automatically configuring financial product offerings. An example method includes: receiving, by a computer system, a graph model representing a plurality of permutations of definition provisions of a financial product; translating at least a subset of the graph model into definitions of a plurality of business objects; translating the definitions of the plurality of business objects into definitions of a plurality of services to be implemented by an offering of the financial product; receiving, via a user interface, a plurality of service configuration options; applying the plurality of service configuration options to the definitions of the plurality of services; and generating, based on the definitions of the plurality of services, service configuration data for the offering of the financial product.

Abstract: Disclosed are methods and systems for automatically configuring financial product offerings. An example method includes: receiving, by a computer system, a graph model representing a plurality of permutations of definition provisions of a financial product; translating at least a subset of the graph model into definitions of a plurality of business objects; translating the definitions of the plurality of business objects into definitions of a plurality of services to be implemented by an offering of the financial product; receiving, via a user interface, a plurality of service configuration options; applying the plurality of service configuration options to the definitions of the plurality of services; and generating, based on the definitions of the plurality of services, service configuration data for the offering of the financial product.

Abstract: Disclosed are methods and systems for model-based data transformation.

Abstract: Disclosed are methods and systems for model-based data transformation.

Abstract: Disclosed are methods and systems for model-based data transformation.

Abstract: Disclosed are methods and systems for automatically configuring financial product offerings. An example method includes: receiving, by a computer system, a graph model representing a plurality of permutations of definition provisions of a financial product; translating at least a subset of the graph model into definitions of a plurality of business objects; translating the definitions of the plurality of business objects into definitions of a plurality of services to be implemented by an offering of the financial product; receiving, via a user interface, a plurality of service configuration options; applying the plurality of service configuration options to the definitions of the plurality of services; and generating, based on the definitions of the plurality of services, service configuration data for the offering of the financial product.

Abstract: Methods, systems, and products are provided for code path tracking. Embodiments include identifying an instrumented trace point in software code to be path tracked; identifying a function executed at the instrumented trace point in the software code; identifying parameters for the function executed at the instrumented trace point; and recording a description of the function, the parameters, and the result of the execution of the function using the parameters.

Abstract: A number of variations may include a product comprising: a semi-autonomous trailer hitch comprising a coupler; a towed device structure, wherein the coupler and the towed device structure are pivotally attached to each other; and at least one sensor on at least one of the coupler or the towed device structure.

Abstract: An adjustable knuckle/steer arm assembly and method for adjusting a toe curve setting of a vehicle wheel is provided. The adjustable knuckle/steer arm assembly includes a knuckle and a steer arm. The steer arm is pivotally connected to the knuckle at a pivot. One of the knuckle and the steer arm has a slot formed therein and the other has a connector member which engages the slot. The steer arm is angularly adjustable with respect to the knuckle via adjustable engagement of the connector member along the slot to enable the toe curve setting to be adjusted.

Abstract: An adjustable knuckle/steer arm assembly and method for adjusting a toe curve setting of a vehicle wheel is provided. The adjustable knuckle/steer arm assembly includes a knuckle and a steer arm. The steer arm is pivotally connected to the knuckle at a pivot. One of the knuckle and the steer arm has a slot formed therein and the other has a connector member which engages the slot. The steer arm is angularly adjustable with respect to the knuckle via adjustable engagement of the connector member along the slot to enable the toe curve setting to be adjusted.

Abstract: A paper towel dispenser with disinfecting contact surface is an apparatus designed to reduce the transmission of communicable disease from indirect physical contact routes of transmission by providing a disinfecting surface that is most frequently engaged by users. The present invention accomplishes through the use of an upright paper towel dispenser that incorporates an absorbent pad in fluid communication with a reservoir containing an antimicrobial solution. The paper towel dispenser with disinfecting contact surface is additionally able to adjust to variety of paper towel sizes through the incorporation of a height adjustment mechanism. The present invention comprises a stationary base, a pedestal assembly, a reservoir assembly, a retaining plate assembly, and a platform assembly. The reservoir would be filled with an antimicrobial solution capable of eliminating germs upon contact. The platform assembly would provide a non-interfering elevated shelf for storing a plurality of secondary items.

Abstract: Methods, systems, and products are provided for code path tracking. Embodiments include identifying an instrumented trace point in software code to be path tracked; identifying a function executed at the instrumented trace point in the software code; identifying parameters for the function executed at the instrumented trace point; and recording a description of the function, the parameters, and the result of the execution of the function using the parameters.

Abstract: Methods, systems, and products are provided for code path tracking. Embodiments include identifying an instrumented trace point in software code to be path tracked; identifying a function executed at the instrumented trace point in the software code; identifying parameters for the function executed at the instrumented trace point; and recording a description of the function, the parameters, and the result of the execution of the function using the parameters.

Abstract: Methods, systems, and products are provided for code path tracking. Embodiments include identifying an instrumented trace point in software code to be path tracked; identifying a function executed at the instrumented trace point in the software code; identifying parameters for the function executed at the instrumented trace point; and recording a description of the function, the parameters, and the result of the execution of the function using the parameters.

Abstract: A system and method of performing “on-the-fly” zooming (i.e., while the video display is in-motion) having infinite value scaling is provided to give the user the ability to zoom-up by any amount while viewing. The variable “on-the-fly” zooming function is performed by a user employing a user interface device, such as a mouse, to select a window of random size in a display screen which is playing an in-motion video display. The information obtained by the user interface device is converted into scaling information and base address information and are stored into temporary registers. On the next video synchronization signal, the scaling and base address information are loaded into registers used to perform scaling on the pixel data retrieved from the frame buffer area in the video system. The new base address ensures that the pixel data is retrieved so that only the data within the window is scaled. The retrieved video data is then scaled using the new scaling information.

Abstract: This invention provides a compound comprising:(1) a polypeptide moiety havinga) an identifying number of amino acids for SPAAT,b) an elastase binding activity; and(2) an extracellular matrix protein bound to the polypeptide moiety.Also provided is a method of inhibiting an elastase comprising contacting the elastase with a polypeptide moiety having:(1) an identifying number of amino acids for SPAAT;(2) a collagen binding activity; and(3) elastase binding activity.