Abstract: Large area cameras that sense light using charge coupled devices are provided. The large area cameras have a scintillator that senses short wavelength (e.g. x-rays) radiation and provides light at a longer wavelength. Optical fibers transmit the light to charge coupled devices arranged in an M×N array. Subsets of the image signals can be summed together to increase signal strength and frame rate. The image signals can be amplified and digitized to accomplish image reconstruction in near-real time for a plurality of CCDs. To accomplish image reconstruction in near-real time for a plurality of CCDs, the digitized signals for one image frame are stored in first memory circuits, while image signals from another frame are read out of second memory circuits. The image signal are written into and read out of the memory circuits in configurations that are independent of the orientation of the CCDs within the CCD array.