Patents by Inventor Edward M. Kennedy

Edward M. Kennedy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240115636
    Abstract: The present disclosure relates to recombinant RNA molecules encoding an oncolytic virus genome. The present disclosure further relates to the encapsulation of the recombinant RNA molecules and the use of the recombinant RNA molecules and/or particles for the treatment and prevention of cancer.
    Type: Application
    Filed: January 6, 2022
    Publication date: April 11, 2024
    Inventors: Lorena LERNER, Edward M. KENNEDY, Christophe QUÉVA, Jessica DETERLING, Jeffrey David BRYANT, Qi-Ying HU, Tooba A. CHEEMA, Sean ESSEX
  • Publication number: 20230416308
    Abstract: The disclosure relates to oncolytic virus derived replicons and capsidation of the same. The disclosure also relates to the incorporation of one or more transgenes encoding payload molecules into the replicon. The disclosure further relates to the encapsulation of the replicon and/or recombinant RNA molecules encoding oncolytic viruses into particles and the use of the replicon and/or particles for the treatment and prevention of cancer.
    Type: Application
    Filed: May 28, 2021
    Publication date: December 28, 2023
    Inventors: Lorena LERNER, Edward M. KENNEDY, Jennifer S. LEE
  • Publication number: 20220380735
    Abstract: The present disclosure provides dual viruses capable of producing a primary virus and a secondary virus, and dual oncolytic viruses capable of producing a primary oncolytic virus and a secondary oncolytic virus.
    Type: Application
    Filed: October 9, 2020
    Publication date: December 1, 2022
    Inventors: Edward M. KENNEDY, Lorena LERNER, Christophe QUEVA, Craig A. STRATHDEE, Jennifer S. LEE
  • Publication number: 20220117902
    Abstract: The present disclosure relates to recombinant RNA molecules encoding an oncolytic virus. The present disclosure further relates to the encapsulation of the recombinant RNA molecules and the use of the recombinant RNA molecules and/or particles for the treatment and prevention of cancer.
    Type: Application
    Filed: January 3, 2020
    Publication date: April 21, 2022
    Inventors: Lorena LERNER, Edward M. KENNEDY, Mitchell H. FINER, Christophe QUÉVA
  • Publication number: 20200224220
    Abstract: The present disclosure relates to polynucleotides comprising a nucleic acid sequence encoding a replication competent viral genome, wherein the polynucleotide is capable of producing a replication competent virus when introduced into a cell by a non-viral delivery vehicle. The present disclosure further relates to the encapsulation of the polynucleotides and the use of the polynucleotides and/or particles for the treatment and prevention of cancer.
    Type: Application
    Filed: July 13, 2018
    Publication date: July 16, 2020
    Inventors: Mitchell H. FINER, Edward M. KENNEDY, Lorena LERNER
  • Publication number: 20190100761
    Abstract: The invention generally relates to compositions (including polynucleotides, constructs, fusion proteins, vectors, and cells) and methods of using such compositions for enhancing gene expression, protein production and viral replication. More specifically, the invention relates to use of m6A sequences and/or YTHDF polypeptides to enhance gene expression or viral replication.
    Type: Application
    Filed: April 6, 2017
    Publication date: April 4, 2019
    Applicant: Duke University
    Inventors: Bryan R. Cullen, Edward M. Kennedy, Hal P. Bogerd, Anand Kornepati, Nicholas Heaton, David Courtney