Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that modulate (e.g., agonizes or partially agonizes) NLRP3 that are useful, e.g., for treating a condition, disease or disorder in which an increase in NLRP3 signaling may correct a deficiency in innate immune activity (e.g., a condition, disease or disorder associated with an insufficient immune response) that contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions as well as other methods of using and making the same.

Abstract: A borehole tool including a unitary, single-piece basepipe having a first end portion, a second end portion, and an intermediate portion between the first end portion and second end portion, the first and second end portions being of larger diameter than the intermediate portion, an operational member having a first end and a second end, the member disposed about the basepipe, the member having an outside diameter no greater than the first end portion and the second end portion. A method for making a screen including wrapping a wire around the basepipe, and forming the filtration media with the wire. A borehole system including a borehole in a subsurface formation, a string disposed in the borehole, and a tool disposed within or as a part of the string.

Abstract: A resource exploration and recovery system includes a first system and a second system extending into a wellbore. The second system includes a completion having a casing defining a wellbore internal diameter. A chemical injection tubing extends from the first system into the completion. The chemical injection tubing includes a terminal end portion. A chemical introduction system is arranged at the first system and is fluidically connected to the chemical injection tubing. The chemical introduction system is operable to deliver a chemical into the chemical injection tubing. A chemical injector assembly is mounted to the terminal end portion. The chemical injection system includes an anchor and a chemical injector valve.

Abstract: A cycling shoe having a sole and an upper coupled to the sole. A projection portion extends off a bottom surface of the sole behind a cleat (attachment) portion of the sole. The projection portion has a first lateral side surface, a second lateral side surface an opposite side of the cycling shoe from the first lateral side surface, a bottom surface, and rounded lateral edges that connect each of the first and second lateral side surfaces to the bottom surface.

Abstract: A system for diverting fluid in a borehole string includes an object configured to be deployed in the borehole string. The borehole string includes a plurality of fluid ports defining a plurality of zones along a length of the borehole string, each fluid port extending from a fluid conduit in the borehole string to at least one of: an annular region of the borehole string and a subterranean region. The object is configured to be advanced by a fluid to a fluid port to obstruct the fluid port and divert the fluid in the borehole string to another fluid port. The object includes a core portion made from a first material having a first property, and an outer portion at least partially surrounding the core portion and made from a second material, the second material being deformable and having a second property that is different than the first property.

Abstract: An Electric Submersible Pump (ESP)-packer arrangement including a mandrel, an ESP assembly disposed on the mandrel, the ESP assembly including a seal, a motor, and a pump, a packer assembly disposed on the mandrel, the packer assembly including an element, and an electric actuator subassembly configured to set the element, and an electrical cable connected to both the motor and the electric actuator. A borehole system including a borehole in a subsurface formation, and an ESP-packer arrangement disposed in the borehole.

Abstract: A system for regulating fluid flow in a geothermal energy production system includes a flow control device disposed in an injector well and/or a producer well, which are disposed in a subterranean region. The injector well includes an outflow port configured to inject a fluid into the region, the producer well includes an inflow port configured to receive the fluid from the region, and the outflow port and the inflow port are in fluid communication via one or more passages in the subterranean region between the injector well and the producer well. The flow control device is configured to restrict a flow of a fluid into the producer well based on a temperature and/or a flow rate of the fluid in the flow control device. The temperature and/or the flow rate selected to maintain a temperature of the fluid entering the producer well within a selected range.

Abstract: A resource exploration and recovery system includes a first system and a second system extending into a wellbore. The second system includes a completion having a casing defining a wellbore internal diameter. Chemical injection tubing extends from the first system into the completion. The chemical injection tubing includes a terminal end portion. A chemical introduction system is arranged at the first system and fluidically connected to the chemical injection tubing. The chemical introduction system is operable to deliver a chemical into the chemical injection tubing. A chemical injector assembly is mounted to the terminal end portion. The chemical injector assembly includes a propulsion system.

Abstract: A resource exploration and recovery system includes a first system and a second system extending into a wellbore. The second system includes a completion having a casing defining a wellbore internal diameter. A chemical injection tubing extends from the first system into the completion. The chemical injection tubing includes a terminal end portion. A chemical introduction system is arranged at the first system and is fluidically connected to the chemical injection tubing. The chemical introduction system is operable to deliver a chemical into the chemical injection tubing. A chemical injector assembly is mounted to the terminal end portion. The chemical injection system includes an anchor and a chemical injector valve.

Abstract: A resource exploration and recovery system including a first system, and a second system extending into a wellbore. The second system includes a completion having a casing defining a wellbore internal diameter. Chemical injection tubing extends from the first system into the completion. The chemical injection tubing includes a terminal end portion. A chemical introduction system is arranged at the first system and fluidically connected to the chemical injection tubing. The chemical introduction system is operable to deliver a chemical into the chemical injection tubing. A chemical injection assembly is mounted to the terminal end portion. The chemical injection system includes an anchor system operable to secure the chemical injection assembly to the casing.

Abstract: A system for diverting fluid in a borehole string includes an object configured to be deployed in the borehole string. The borehole string includes a plurality of fluid ports defining a plurality of zones along a length of the borehole string, each fluid port extending from a fluid conduit in the borehole string to at least one of: an annular region of the borehole string and a subterranean region. The object is configured to be advanced by a fluid to a fluid port to obstruct the fluid port and divert the fluid in the borehole string to another fluid port. The object includes a core portion made from a first material having a first property, and an outer portion at least partially surrounding the core portion and made from a second material, the second material being deformable and having a second property that is different than the first property.

Abstract: A system for regulating fluid flow in a geothermal energy production system includes a flow control device disposed in an injector well and/or a producer well, which are disposed in a subterranean region. The injector well includes an outflow port configured to inject a fluid into the region, the producer well includes an inflow port configured to receive the fluid from the region, and the outflow port and the inflow port are in fluid communication via one or more passages in the subterranean region between the injector well and the producer well. The flow control device is configured to restrict a flow of a fluid into the producer well based on a temperature and/or a flow rate of the fluid in the flow control device. The temperature and/or the flow rate selected to maintain a temperature of the fluid entering the producer well within a selected range.

Abstract: A method for preparing a borehole for fracturing including inserting an assembly comprising a fracture plug, a setting tool, a perforating gun and a controller into a borehole, delivering the assembly to a target location, automatically recognizing the target location, automatically setting the plug of the assembly at the target location, and automatically initiating the gun of the assembly to perforate the borehole.

Abstract: A cycling shoe having a sole and an upper coupled to the sole. A projection portion extends off a bottom surface of the sole behind a cleat (attachment) portion of the sole. The projection portion has a first lateral side surface, a second lateral side surface an opposite side of the cycling shoe from the first lateral side surface, a bottom surface, and rounded lateral edges that connect each of the first and second lateral side surfaces to the bottom surface.

Abstract: A cycling shoe has a sole and an upper attached to the sole. An adjustable closure panel extends across an opening in the upper. A lever assembly is exposed at an outer, rear surface of the upper, and is movable about a hinge between a first position and a second position. One or more passages extend through the cycling shoe to accommodate one or more cables to connect the lever assembly to the adjustable closure panel. The lever assembly is configured such that moving the lever assembly between the first position and the second position causes the one or more cables, if connected between the lever assembly to the adjustable closure panel, to tighten or loosen the closure panel relative to the upper.

Abstract: A refrigerator appliance is provided having a fresh food chamber, a convertible chamber, and a freezer chamber. A fan urges a flow of cooled air from an evaporator chamber into a freezer supply duct and a secondary supply duct. A damper housing defines an inlet in fluid communication with the secondary supply duct, a first outlet in fluid communication with the convertible chamber, and a second outlet in fluid communication with the fresh food chamber. A rotary damper is mounted within the damper housing and is selectively rotated to block the flow of cooling air or to supply the flow of cooling air to one or both of the convertible chamber and the fresh food chamber.

Abstract: A method of closing a fluid flow path in a wellbore is disclosed that in one non-limiting embodiment includes: supplying a flexible structure having a selected shape sufficient to seat on an opening of the fluid flow path, the flexible structure including pores of selected dimensions; determining seating of the flexible structure on the opening of the fluid flow path from a sensor measurement; and supplying a slurry containing a sealant to the flexible structure seated on the opening of the fluid flow path to plug the pores with the sealant to close the fluid flow path.

Abstract: A refrigerator appliance is provided including a freezer chamber divided into a first compartment and a second compartment by a removable mullion. A first evaporator cover is positioned within the first compartment to define a first evaporator chamber and a second evaporator cover is positioned within the second compartment to define a second evaporator chamber. A crossover duct is defined in the mullion for providing fluid communication between the first evaporator chamber and the second evaporator chamber.