Patents by Inventor Edward Sturrock

Edward Sturrock has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystals of angiotensin-converting enzyme (ACE)
    Patent number: 9670473
    Abstract: The present invention relates to a crystal. In particular the present invention relates to a crystal of the N-domain of ACE protein. The present invention also relates to methods, processes, domain specific modulators, pharmaceutical compositions and uses of the N-domain crystal and the structure co-ordinates thereof.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: June 6, 2017
    Assignee: Angiodesign (UK) Limited
    Inventors: Ravi Acharya, Edward Sturrock
  • CRYSTAL
    Publication number: 20160333334
    Abstract: The present invention relates to a crystal. In particular the present invention relates to a crystal of the N-domain of ACE protein. The present invention also relates to methods, processes, domain specific modulators, pharmaceutical compositions and uses of the N-domain crystal and the structure co-ordinates thereof.
    Type: Application
    Filed: August 4, 2016
    Publication date: November 17, 2016
    Inventors: Ravi Acharya, Edward Sturrock
  • Crystal
    Patent number: 9434933
    Abstract: The present invention relates to a crystal. In particular the present invention relates to a crystal of the N-domain of ACE protein. The present invention also relates to methods, processes, domain specific modulators, pharmaceutical compositions and uses of the N-domain crystal and the structure co-ordinates thereof.
    Type: Grant
    Filed: June 5, 2014
    Date of Patent: September 6, 2016
    Assignee: ANGIODESIGN (UK) LTD.
    Inventors: Ravi Acharya, Edward Sturrock
  • CRYSTAL
    Publication number: 20140377836
    Abstract: The present invention relates to a crystal. In particular the present invention relates to a crystal of the N-domain of ACE protein. The present invention also relates to methods, processes, domain specific modulators, pharmaceutical compositions and uses of the N-domain crystal and the structure co-ordinates thereof.
    Type: Application
    Filed: June 5, 2014
    Publication date: December 25, 2014
    Applicants: UNIVERSITY OF BATH, UNIVERSITY OF CAPE TOWN
    Inventors: Ravi Acharya, Edward Sturrock
  • Crystal structure of the N-terminal domain of angiotensin converting enzyme and uses thereof
    Patent number: 8796006
    Abstract: The present invention relates to a crystal. In particular the present invention relates to a crystal of the N-domain of ACE protein. The present invention also relates to methods, processes, domain specific modulators, pharmaceutical compositions and uses of the N-domain crystal and the structure co-ordinates thereof.
    Type: Grant
    Filed: January 10, 2007
    Date of Patent: August 5, 2014
    Assignees: University of Bath, University of Cape Town
    Inventors: Ravi Acharya, Edward Sturrock
  • Crystal structure of an angiotensin-converting enzyme (ACE) and uses thereof
    Patent number: 8594947
    Abstract: The present invention relates to a crystal of ACE protein. The present invention further relates to methods, processes, ACE modulators, pharmaceutical compositions and uses of the ACE crystal and the structure co-ordinates thereof.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: November 26, 2013
    Assignees: University of Bath, University of Cape Town
    Inventors: Ravi Acharya, Edward Sturrock
  • Angiotensin I-converting enzyme (ACE) inhibitors
    Patent number: 7981922
    Abstract: This invention relates to a process for synthesizing an amino acid derivative of a tripeptidomimetic, such as lisinopril. The invention also relates to a derivative of lisinopril, incorporating a amino acid moeity such as tryptophan at the P2? position.
    Type: Grant
    Filed: May 29, 2006
    Date of Patent: July 19, 2011
    Assignee: University of Cape Town
    Inventors: Edward Sturrock, Aloysius Nchinda, Kelly Chibale
  • Angiotensin I-converting enzyme (ACE) inhibitors
    Patent number: 7951834
    Abstract: This invention relates to a process for the synthesis of ketomethylene derivatives of the tripeptide Phe-Gly-Pro (“keto-ACE”, compound 5a) and analogues thereof. The synthesis process proceeds via an ?,?-unsaturated keto intermediate. A key feature of the process involves a Horner-Emmons olefination of the, -unsaturated keto-phosphonate with ethyl glyoxylate. Keto-ACE analogues produced by the process of the invention display C-domain selectivity.
    Type: Grant
    Filed: May 29, 2006
    Date of Patent: May 31, 2011
    Assignee: University of Cape Town
    Inventors: Edward Sturrock, Aloysius Nchinda, Kelly Chibale
  • Crystal Structure of an Angiotensin-Converting Enzyme (ACE) and Uses Thereof
    Publication number: 20100160180
    Abstract: The present invention relates to a crystal of ACE protein. The present invention further relates to methods, processes, ACE modulators, pharmaceutical compositions and uses of the ACE crystal and the structure co-ordinates thereof.
    Type: Application
    Filed: February 26, 2010
    Publication date: June 24, 2010
    Applicants: UNIVERSITY OF BATH, University of Cape Town
    Inventors: Ravi Acharya, Edward Sturrock
  • Crystal structure of an angiotensin-converting enzyme (ACE) and uses thereof
    Patent number: 7704319
    Abstract: The present invention relates to a crystal of ACE protein. The present invention further relates to methods, processes, ACE modulators, pharmaceutical compositions and uses of ACE crystal and the structure coordinates thereof.
    Type: Grant
    Filed: September 12, 2003
    Date of Patent: April 27, 2010
    Assignees: University of Bath, University of Cape Town
    Inventors: Ravi Acharya, Edward Sturrock
  • Angiotensin I-converting enzyme (ace) inhibitors
    Publication number: 20090281160
    Abstract: This invention relates to a process for the synthesis of ketomethylene derivatives of the tripeptide Phe-Gly-Pro (“keto-ACE”, compound 5a) and analogues thereof. The synthesis process proceeds via an ?,?-unsaturated keto intermediate. A key feature of the process involves a Horner-Emmons olefination of the, -unsaturated keto-phosphonate with ethyl glyoxylate. Keto-ACE analogues produced by the process of the invention display C-domain selectivity.
    Type: Application
    Filed: May 29, 2006
    Publication date: November 12, 2009
    Inventors: Edward Sturrock, Aloysius Nchinda, Kelly Chibale
  • Angiotensin I-Converting Enzyme (ACE) Inhibitors
    Publication number: 20090118351
    Abstract: This invention relates to a process for synthesising an amino acid derivative of a tripeptidomimetic, such as lisinopril. The invention also relates to a derivative of lisinopril, incorporating a amino acid moeity such as tryptophan at the P2? position.
    Type: Application
    Filed: May 29, 2006
    Publication date: May 7, 2009
    Inventors: Edward Sturrock, Aloysius Nchinda, Kelly Chibale
  • Crystal structure of an angiotensin-converting enzyme (ace) and uses thereof
    Publication number: 20060174816
    Abstract: The present invention relates to a crystal of ACE protein. The present invention further relates to methods, processes, ACE modulators, pharmaceutical compositions and uses of the ACE crystal and the structure co-ordinates thereof.
    Type: Application
    Filed: September 12, 2003
    Publication date: August 10, 2006
    Applicant: UNIVERSITY OF BATH
    Inventors: Ravi Acharya, Edward Sturrock