Patents by Inventor Edward Turos
Edward Turos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11857679Abstract: The subject invention pertains to polyacrylate homopolymers produced from acrylolated drug monomers. The homopolymers can be produced in the form of nanoparticles. The nanoparticles comprising the homopolymers can be produced via a free radical-induced emulsion polymerization of the acrylolated drug monomers to produce an aqueous emulsion of uniformly sized nanoparticles. The homopolymers of the invention containing acrylolated antibiotic monomers can be active against Gram-positive and Gram-negative bacteria, such as Staphylococcus aureus and Escherichia coli. Accordingly, methods are provided of treating a disease, for example, an infection, by administering to a subject the homopolymers, homopolymeric nanoparticles, or emulsions containing homopolymeric nanoparticles of the invention.Type: GrantFiled: September 13, 2021Date of Patent: January 2, 2024Assignee: UNIVERSITY OF SOUTH FLORIDAInventors: Edward Turos, Faeez Mahzamani
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Publication number: 20210401747Abstract: The subject invention pertains to polyacrylate homopolymers produced from acrylolated drug monomers. The homopolymers can be produced in the form of nanoparticles. The nanoparticles comprising the homopolymers can be produced via a free radical-induced emulsion polymerization of the acrylolated drug monomers to produce an aqueous emulsion of uniformly sized nanoparticles. The homopolymers of the invention containing acrylolated antibiotic monomers can be active against Gram-positive and Gram-negative bacteria, such as Staphylococcus aureus and Escherichia coli. Accordingly, methods are provided of treating a disease, for example, an infection, by administering to a subject the homopolymers, homopolymeric nanoparticles, or emulsions containing homopolymeric nanoparticles of the invention.Type: ApplicationFiled: September 13, 2021Publication date: December 30, 2021Applicant: UNIVERSITY OF SOUTH FLORIDAInventors: EDWARD TUROS, FAEEZ MAHZAMANI
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Patent number: 11116725Abstract: The subject invention pertains to polyacrylate homopolymers produced from acrylolated drug monomers. The homopolymers can be produced in the form of nanoparticles. The nanoparticles comprising the homopolymers can be produced via a free radical-induced emulsion polymerization of the acrylolated drug monomers to produce an aqueous emulsion of uniformly sized nanoparticles. The homopolymers of the invention containing acrylolated antibiotic monomers can be active against Gram-positive and Gram-negative bacteria, such as Staphylococcus aureus and Escherichia coil. Accordingly, methods are provided of treating a disease, for example, an infection, by administering to a subject the homopolymers, homopolymeric nanoparticles, or emulsions containing homopolymeric nanoparticles of the invention.Type: GrantFiled: November 7, 2018Date of Patent: September 14, 2021Assignee: UNIVERSITY OF SOUTH FLORIDAInventors: Edward Turos, Faeez Mahzamani
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Patent number: 10588860Abstract: The present invention comprises poly(vinyl benzoate) nanoparticle suspensions as molecular carriers. These nanoparticles can be formed by nanoprecipitation of poly(vinyl benzoate) in water using Pluronic F68 as surfactant, to create spherical nanostructures measuring about 200-250 nm in diameter which are stable in phosphate buffer and blood serum, and only slowly degrade in the presence of esterases. Kinetics experiments in phosphate buffer indicate that 78% of the coumarin-6 was encapsulated within the polymer matrix of the nanoparticle, and the residual 22% of coumarin-6 was surface-bound and quickly released. The nanoparticles are non-toxic in vitro towards human epithelial cells (IC50>1000 ?g/mL) and primary bovine primary aortic endothelial cells (IC50>500 ?g/mL), and exert non-observable bactericidal activity against a selection of representative test microbes (MIC>250 ?g/mL).Type: GrantFiled: August 4, 2016Date of Patent: March 17, 2020Assignee: University of South FloridaInventors: Edward Turos, Raphael Labruere, Ryan Scott Cormier, Renaud Sicard
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Patent number: 10350177Abstract: Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.Type: GrantFiled: August 20, 2018Date of Patent: July 16, 2019Assignee: University of South FloridaInventors: Edward Turos, Praveen Ramaraju
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Publication number: 20190133944Abstract: The subject invention pertains to polyacrylate homopolymers produced from acrylolated drug monomers. The homopolymers can be produced in the form of nanoparticles. The nanoparticles comprising the homopolymers can be produced via a free radical-induced emulsion polymerization of the acrylolated drug monomers to produce an aqueous emulsion of uniformly sized nanoparticles. The homopolymers of the invention containing acrylolated antibiotic monomers can be active against Gram-positive and Gram-negative bacteria, such as Staphylococcus aureus and Escherichia coil. Accordingly, methods are provided of treating a disease, for example, an infection, by administering to a subject the homopolymers, homopolymeric nanoparticles, or emulsions containing homopolymeric nanoparticles of the invention.Type: ApplicationFiled: November 7, 2018Publication date: May 9, 2019Applicant: University of South FloridaInventors: EDWARD TUROS, FAEEZ MAHZAMANI
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Publication number: 20180369163Abstract: Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.Type: ApplicationFiled: August 20, 2018Publication date: December 27, 2018Applicant: University of South FloridaInventors: Edward Turos, Praveen Ramaraju
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Patent number: 10080725Abstract: Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.Type: GrantFiled: November 11, 2016Date of Patent: September 25, 2018Assignee: University of South FloridaInventors: Edward Turos, Praveen Ramaraju
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Patent number: 10010545Abstract: Embodiments of the present disclosure provide for compositions including an antibiotic containing a N-thiolated beta-lactam moiety, pharmaceutical compositions including the antibiotic, methods of treatment of a condition (e.g., bacterial infection), methods of treatment using compositions or pharmaceutical compositions, and the like.Type: GrantFiled: April 26, 2017Date of Patent: July 3, 2018Assignee: University of South FloridaInventors: Edward Turos, Biplob Bhattacharya
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Patent number: 9949480Abstract: The present invention provides N-alkylthio ?-lactams and disulfide compounds (e.g., alkyl-coenzyme A asymmetric disulfides or aryl-alkyl disulfides), compositions containing such compounds, and methods of their use as anti-bacterial agents.Type: GrantFiled: July 29, 2015Date of Patent: April 24, 2018Assignee: UNIVERSITY OF SOUTH FLORIDAInventors: Edward Turos, Kevin D. Revell
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Patent number: 9670179Abstract: Embodiments of the present disclosure provide for compositions including an antibiotic containing a N-thiolated beta-lactam moiety, pharmaceutical compositions including the antibiotic, methods of treatment of a condition (e.g., bacterial infection), methods of treatment using compositions or pharmaceutical compositions, and the like.Type: GrantFiled: March 13, 2014Date of Patent: June 6, 2017Assignee: University of South FloridaInventors: Edward Turos, Biplob Bhattacharya
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Publication number: 20170056337Abstract: Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.Type: ApplicationFiled: November 11, 2016Publication date: March 2, 2017Applicant: University of South FloridaInventors: Edward Turos, Praveen Ramaraju
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Patent number: 9533051Abstract: The subject invention pertains to formulations comprising poly(menthyl acrylate) nanoparticles comprising at least one active ingredient contained in a plurality of hydrophobic carriers and dispersed in an aqueous medium. The subject invention further pertains to methods of polymerization of drug loaded nanoparticles made up of methyl acrylate monomers in an aqueous emulsion.Type: GrantFiled: December 3, 2015Date of Patent: January 3, 2017Assignee: University of South FloridaInventors: Edward Turos, Faeez Sisan Mahzamani, Ashleigh Brooke Bachman, Kristy Lineth Flores
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Patent number: 9512160Abstract: Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.Type: GrantFiled: April 22, 2010Date of Patent: December 6, 2016Assignee: University of South FloridaInventors: Edward Turos, Praveen Ramaraju
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Publication number: 20160338962Abstract: The present invention comprises poly(vinyl benzoate) nanoparticle suspensions as molecular carriers. These nanoparticles can be formed by nanoprecipitation of poly(vinyl benzoate) in water using Pluronic F68 as surfactant, to create spherical nanostructures measuring about 200-250 nm in diameter which are stable in phosphate buffer and blood serum, and only slowly degrade in the presence of esterases. Kinetics experiments in phosphate buffer indicate that 78% of the coumarin-6 was encapsulated within the polymer matrix of the nanoparticle, and the residual 22% of coumarin-6 was surface-bound and quickly released. The nanoparticles are non-toxic in vitro towards human epithelial cells (IC50>1000 ?g/mL) and primary bovine primary aortic endothelial cells (IC50>500 ?g/mL), and exert non-observable bactericidal activity against a selection of representative test microbes (MIC>250 ?g/mL).Type: ApplicationFiled: August 4, 2016Publication date: November 24, 2016Applicant: University of South FloridaInventors: Edward Turos, Raphael Labruere, Ryan Scott Cormier, Renaud Sicard
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Publication number: 20160338969Abstract: A biocompatible polymer material is described that exhibits mechanical and physical properties that are fundamental to many medical devices and treatment of many medical diseases and disorders. The material is composed of a combination of acrylate monomers polymerized via a microemulsion polymerization. Multiple applications of the polymer material are presented.Type: ApplicationFiled: May 25, 2016Publication date: November 24, 2016Applicant: University of South FloridaInventors: Kerriann Robyn Greenhalgh, Edward Turos
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Patent number: 9433581Abstract: The present invention comprises poly(vinyl benzoate) nanoparticle suspensions as molecular carriers. These nanoparticles can be formed by nanoprecipitation of poly(vinyl benzoate) in water using Pluronic F68 as surfactant, to create spherical nanostructures measuring about 200-250 nm in diameter which are stable in phosphate buffer and blood serum, and only slowly degrade in the presence of esterases. Kinetics experiments in phosphate buffer indicate that 78% of the coumarin-6 was encapsulated within the polymer matrix of the nanoparticle, and the residual 22% of coumarin-6 was surface-bound and quickly released. The nanoparticles are non-toxic in vitro towards human epithelial cells (IC50>1000 ?g/mL) and primary bovine primary aortic endothelial cells (IC50>500 ?g/mL), and exert non-observable bactericidal activity against a selection of representative test microbes (MIC>250 ?g/mL).Type: GrantFiled: May 20, 2013Date of Patent: September 6, 2016Assignee: University of South FloridaInventors: Edward Turos, Raphael Labruere, Ryan Scott Cormier, Renaud Sicard
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Publication number: 20160158364Abstract: The subject invention pertains to formulations comprising poly(menthyl acrylate) nanoparticles comprising at least one active ingredient contained in a plurality of hydrophobic carriers and dispersed in an aqueous medium. The subject invention further pertains to methods of polymerization of drug loaded nanoparticles made up of methyl acrylate monomers in an aqueous emulsion.Type: ApplicationFiled: December 3, 2015Publication date: June 9, 2016Applicant: University of South FloridaInventors: Edward Turos, Faeez Sisan Mahzamani, Ashleigh Brooke Bachman, Kristy Lineth Flores
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Publication number: 20150327547Abstract: The present invention provides N-alkylthio ?-lactams and disulfide compounds (e.g., alkyl-coenzyme A asymmetric disulfides or aryl-alkyl disulfides), compositions containing such compounds, and methods of their use as anti-bacterial agents.Type: ApplicationFiled: July 29, 2015Publication date: November 19, 2015Applicant: UNIVERSITY OF SOUTH FLORIDAInventors: EDWARD TUROS, KEVIN D. REVELL
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Patent number: 9149440Abstract: This invention relates to polymeric nanoparticles useful for drug delivery with target molecules bonded to the surface of the particles and having sizes of up to 1000 nm, preferably 1 nm to 400 nm, more preferably 1 nm to 200 nm, that are dispersed homogeneously in aqueous solution. The target drug/target substance is covalently bonded to the novel polymeric nanoparticles to secure them from outer intervention in vivo or cell culture in vitro until they are exposed at the target site within the cell. This invention also relates to microemulsion polymerization techniques useful for preparing the novel nanoparticles.Type: GrantFiled: September 2, 2004Date of Patent: October 6, 2015Assignee: UNIVERSITY OF SOUTH FLORIDAInventors: Edward Turos, Jeung-Yeop Shim