Patents by Inventor Edwin J. Hamilton, Jr.

Edwin J. Hamilton, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stabilization of growth hormones
    Patent number: 4816568
    Abstract: Growth hormones are admixed with various stabilizers to provide for the decreased formation of insolubles and preservation of the soluble bioactivity of the growth hormone in aqueous environments. Examples of such stabilizers include certain polyols, amino acids, polymers of amino acids having a charged side group at physiological PH, and choline salts.
    Type: Grant
    Filed: May 16, 1986
    Date of Patent: March 28, 1989
    Assignee: International Minerals & Chemical Corp.
    Inventors: Edwin J. Hamilton, Jr., Bruce D. Burleigh
  • Isolation of bioactive, monomeric growth hormone
    Patent number: 4705848
    Abstract: Monomeric, biologically active growth hormone is isolated from microbially-produced insoluble inclusion bodies by solubilizing and denaturing the growth hormone by extraction of the inclusion bodies into a guanidine salt solution such as guanidine hydrochloride and subsequently renaturing at least a portion of the growth hormone in the solution by replacing the guanidine salt solution with a denaturant-free buffer solution and removing precipitated impurities and growth hormone aggregates. The renatured growth hromone is then purified by ion-exchange chromatography.
    Type: Grant
    Filed: June 2, 1986
    Date of Patent: November 10, 1987
    Assignee: International Minerals & Chemical Corp.
    Inventors: Ren-Der Yang, Edwin J. Hamilton, Jr., Larry D. Taber