Patents by Inventor Ehud Gazit

Ehud Gazit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240009177
    Abstract: Combination compositions exhibiting anti-viral activities are provided, which are based on unique combinations of polyphenol zinc ionophores. Exemplary compositions comprise combinations of flavonoid zinc ionophores selected from EGCG, quercetin and taxifolin, preferably further comprising a zinc compound and a copper compound. The compositions preferably contain additional ingredients to further enhance the anti-viral effect of the composition and/or to provide additional benefits.
    Type: Application
    Filed: September 19, 2021
    Publication date: January 11, 2024
    Inventors: Dor ZAGURI, Topaz KREISER-SHEM-TOV, Ehud GAZIT, Daniel SEGAL, Josef MOGRABI, Eran BACHARACH
  • Patent number: 11827687
    Abstract: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.
    Type: Grant
    Filed: February 3, 2022
    Date of Patent: November 28, 2023
    Assignee: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventors: Genady Kostenich, Mor Oron-Herman, Arie Orenstein, Talia Shekhter Zahavi, Ehud Gazit, Yoseph Salitra, Ludmilla Buzhansky
  • Patent number: 11773060
    Abstract: A formulation includes an active agent, a thickening/solidifying agent, and an antioxidant. The active agent is 9-cis-?-carotene (9CBC) or a derivative thereof of the following formula: where R2 is H or methyl; X is optionally substituted with one or more methyl groups; n is an integer of 0-16; and the asterisk represents the point of attachment to the cyclohexene ring.
    Type: Grant
    Filed: October 11, 2021
    Date of Patent: October 3, 2023
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Ehud Gazit, Ludmila Buzhansky, Michael Ioffe, Alon Sayer
  • Publication number: 20230301200
    Abstract: A spin-selective conduction structure comprises a crystal having a monolayer of metal atoms between two layers of chiral organic molecules. Each metal atom is coupled to two chiral organic molecules, one at each layer, wherein a chirality of organic molecules in one of the two layers is the same as a chirality of organic molecules in another one of the two layers.
    Type: Application
    Filed: March 8, 2021
    Publication date: September 21, 2023
    Applicants: Ramot at Tel-Aviv University Ltd., Yeda Research and Development Co. Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Ehud GAZIT, Ron NAAMAN, Yossi PALTIEL, Shira YOCHELIS, Sharon GILEAD, Pandeeswar MAKAM, Amit Kumar MONDAL, Noam BROWN, Naama GOREN
  • Publication number: 20220390471
    Abstract: The present disclosure provides yeast screening system/s and methods for screening of candidate therapeutic compound/s for treating, at least one proteniopathy and/or protein misfolding disorder. More specifically, the present disclosure provides systems and methods for identifying a therapeutic compound that inhibit Hcy fibril formation and uses thereof in treating Alzheimer's disease.
    Type: Application
    Filed: June 2, 2022
    Publication date: December 8, 2022
    Inventors: Ehud GAZIT, Dana LAOR, Dorin SADE YAZDI
  • Patent number: 11421226
    Abstract: The present invention provides cell-free systems comprising: (i) a transcription compartment; (ii) a barrier; and (iii) a translation compartment, methods for producing proteins and performing post-translational modifications thereon using such systems, and kits comprising such systems.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: August 23, 2022
    Assignee: RAMOT AT TEL-AVIV UNIVERSITY LTD.
    Inventors: Shai Zilberzwige-Tal, Ehud Gazit, Johann Elbaz
  • Patent number: 11389544
    Abstract: The present invention provides nanoparticle conjugates incorporating the self-assembling module diphenylalanine (FF) dipeptide into a bioactive moiety. The conjugate self-assembles to form distinct nanometric structures such as nanospheres. The present invention further provides nanoparticles formed by supramolecular co-assembly of the conjugates with a diphenylalanine (FF) dipeptide or analog thereof, to generate bioactive self-assembled nanostructures.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: July 19, 2022
    Assignees: RAMOT AT TEL-AVIV UNIVERSITY LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventors: Talia Shekhter Zehavi, Ehud Gazit, Mor Herman-Oron, Genady Kostenich, Arie Orenstein
  • Publication number: 20220190232
    Abstract: A piezoelectric transducer is provided herein, comprising a three-dimensional structure made of a plurality of peptides, the peptides being self-assembling and the structure being piezoelectric, wherein at least a portion, or each, of said plurality of peptides comprises peptides of 2 to 10 amino acid residues, provided that the plurality of peptides is not consisted of a plurality of Phe-Phe dipeptides. Further described herein are peptides having an amino acid sequence Hyp-Phe-Phe, Boc-Dip-Dip, (L)Trp-(D)Trp or (D)Trp-(L)Trp, as well as three-dimensional structures comprising such peptides.
    Type: Application
    Filed: March 25, 2020
    Publication date: June 16, 2022
    Applicants: Ramot at Tel-Aviv University Ltd., Xidian University
    Inventors: Ehud GAZIT, Santu BERA, Yu CHEN, Sharon GILEAD, Kai TAO, Sigal LAZAR, Rusen YANG, Sudipta MONDAL, Vasantha BASAVALINGAPPA
  • Publication number: 20220162284
    Abstract: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.
    Type: Application
    Filed: February 3, 2022
    Publication date: May 26, 2022
    Applicants: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD., RAMOT AT TEL AVIV UNIVERSITY LTD.
    Inventors: Genady KOSTENICH, Mor ORON-HERMAN, Arie ORENSTEIN, Talia SHEKHTER ZAHAVI, Ehud GAZIT, Yoseph SALITRA, Ludmilla BUZHANSKY
  • Publication number: 20220098149
    Abstract: A formulation includes an active agent, a thickening/solidifying agent, and an antioxidant. The active agent is 9-cis-?-carotene (9CBC) or a derivative thereof of the following formula: where R2 is H or methyl; X is optionally substituted with one or more methyl groups; n is an integer of 0-16; and the asterisk represents the point of attachment to the cyclohexene ring.
    Type: Application
    Filed: October 11, 2021
    Publication date: March 31, 2022
    Inventors: Ehud Gazit, Ludmila Buzhansky, Michael Ioffe, Alon Sayer
  • Patent number: 11285115
    Abstract: Compositions comprising self-assembled hydrogel particles formed of short peptides which comprise one or more aromatic amino acid residue(s) in an inverted emulsion are disclosed. Such hydrogel particles which encapsulate an active agent and uses thereof in therapeutic and diagnostic applications are also disclosed.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: March 29, 2022
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Rafael Ischakov, Ludmila Buzhansky, Lihi Adler-Abramovich, Ehud Gazit
  • Patent number: 11261230
    Abstract: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.
    Type: Grant
    Filed: June 28, 2020
    Date of Patent: March 1, 2022
    Assignees: RAMOT AT TEL AVIV UNIVERSITY LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventors: Genady Kostenich, Mor Oron-Herman, Arie Orenstein, Talia Shekhter Zahavi, Ehud Gazit, Yoseph Salitra, Ludmila Buzhansky
  • Publication number: 20220041651
    Abstract: A thermally stable composition having at least one aromatic cyclic di-peptide is provided having a thermal sustainability of up to 680 Kelvin. The thermally stable compositions can be used in high temperature applications.
    Type: Application
    Filed: August 4, 2021
    Publication date: February 10, 2022
    Inventors: Kai TAO, Sigal LAZAR, Sharon GILEAD, Ehud GAZIT
  • Publication number: 20210395312
    Abstract: Self-assembled structures formed of a plurality of cyclic peptides which are in association with metal ions is provided. The cyclic peptides are each of from 2 to 6 amino acid residues, and two or more of the amino acid residues are each independently an aromatic amino acid residue. The self-assembled structures exhibit photoluminescence and can be used or incorporated in light emitting systems.
    Type: Application
    Filed: September 6, 2021
    Publication date: December 23, 2021
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Ehud GAZIT, Kai TAO, Yu CHEN, Sharon GILEAD, Sigal LAZAR, Pandeeswar MAKAM
  • Publication number: 20210381022
    Abstract: The invention relates to in vivo systems and high throughput screening platform for drugs applicable in inborn error of metabolism (IEM) disorders. More specifically, the invention provides yeast screening system of candidate therapeutic compounds applicable in IEM disorders associated with accumulation of at least one metabolite. The systems of the invention comprise yeast cell/s that carry at least one manipulation in at least one yeast metabolic pathway, that leads to accumulation of said metabolite.
    Type: Application
    Filed: June 11, 2021
    Publication date: December 9, 2021
    Inventors: Ehud GAZIT, Dana LAOR
  • Patent number: 11142496
    Abstract: The present invention relates to a method for total chemical synthesis of 9-cis-?-carotene (9CBC), and further provides stable formulations thereof.
    Type: Grant
    Filed: May 21, 2017
    Date of Patent: October 12, 2021
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Ehud Gazit, Ludmila Buzhansky, Michael Ioffe, Alon Sayer
  • Patent number: 11124543
    Abstract: Ordered structures composed of a plurality of self-assembled peptide nucleic acid (PNA) monomers, and processes of generating same are provided. The plurality of PNA monomers includes modified PNA monomers which are N-protected PNA monomers and/or which feature at least one aromatic moiety attached to a backbone, a nucleobase and/or a nucleobase linkage unit of the PNA monomer. Tunable photonic crystals formed of the provided ordered structures, uses thereof and articles-of-manufacturing containing same are also provided.
    Type: Grant
    Filed: October 19, 2016
    Date of Patent: September 21, 2021
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Or Berger, Lihi Adler-Abramovich, Ehud Gazit
  • Publication number: 20210170048
    Abstract: The present invention provides nanoparticle conjugates incorporating the self-assembling module diphenylalanine (FF) dipeptide into a bioactive moiety. The conjugate self-assembles to form distinct nanometric structures such as nanospheres. The present invention further provides nanoparticles formed by supramolecular co-assembly of the conjugates with a diphenylalanine (FF) dipeptide or analog thereof, to generate bioactive self-assembled nanostructures.
    Type: Application
    Filed: January 19, 2017
    Publication date: June 10, 2021
    Inventors: Talia SHEKHTER ZEHAVI, Ehud GAZIT, Mor HERMAN-ORON, Genady KOSTENICH, Arie ORENSTEIN
  • Publication number: 20210128414
    Abstract: A composition containing a plurality of self-assembled nanostructures formed of a plurality of aromatic molecules which include an aromatic amino acid, and which exhibits an antibacterial activity is provided. The composition can be a dental composition which further comprises a dental formulation such as a curable dental formulation, for forming dental composite materials such as dental restorative composite materials. Processes of preparing the composition and uses thereof are also provided.
    Type: Application
    Filed: January 11, 2021
    Publication date: May 6, 2021
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Lihi ADLER-ABRAMOVICH, Lee SCHNAIDER, Shlomo MATALON, Tamar BROSH, Raphael PILO, Ehud GAZIT
  • Publication number: 20210030918
    Abstract: Provided herein are composite structures that include a core fiber and a plurality of peptide-based self-assembled nanostructures attached thereto, wherein the nanostructures may be loaded with a bioactive agent, such that the composite structures may act as slow-release drug-delivery medical device. Also provided is process for producing the composite structures, and uses thereof.
    Type: Application
    Filed: July 30, 2020
    Publication date: February 4, 2021
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Lihi ADLER-ABRAMOVICH, Ehud GAZIT, Irena GRIGORIANTS, Lialy KHADEJA, Sharon GILEAD