Patents by Inventor Ehud Gazit

Ehud Gazit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190367451
    Abstract: The present invention relates to a method for total chemical synthesis of 9-cis-?-carotene (9CBC), and further provides stable formulations thereof.
    Type: Application
    Filed: May 21, 2017
    Publication date: December 5, 2019
    Inventors: Ehud Gazit, Ludmila Buzhansky, Michael Ioffe, Alon Sayer
  • Patent number: 10446768
    Abstract: Ordered (e.g., self-assembled) structures, arranged from peptide nucleic acids and/or analogs thereof, are disclosed. The peptide nucleic acids forming the ordered structures comprise from 1 to 10 PNA backbone units, at least one comprising a guanine nucleobase or an analog thereof. Processes of generating the ordered structures, uses thereof and articles-of manufacturing, devices and systems containing same are also disclosed.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: October 15, 2019
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Or Berger, Lihi Adler-Abramovich, Ehud Gazit
  • Publication number: 20190276513
    Abstract: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.
    Type: Application
    Filed: March 19, 2019
    Publication date: September 12, 2019
    Applicants: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD., RAMOT AT TEL AVIV UNIVERSITY LTD.
    Inventors: Genady KOSTENICH, Mor ORON-HERMAN, Arie ORENSTEIN, Talia SHEKHTER ZAHAVI, Ehud GAZIT, Yoseph SALITRA, Ludmila BUZHANSKY
  • Patent number: 10266579
    Abstract: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: April 23, 2019
    Assignees: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD., RAMOT AT TEL AVIV UNIVERSITY LTD.
    Inventors: Genady Kostenich, Mor Oron-Herman, Arie Orenstein, Talia Shekhter Zahavi, Ehud Gazit, Yoseph Salitra, Ludmila Buzhansky
  • Patent number: 10245351
    Abstract: Hybrid hydrogels formed of a plurality of peptides that are capable of self-assembling into a hydrogel in an aqueous solution and a biocompatible polymer that is characterized by high swelling capability, high elasticity and low mechanical strength are disclosed, with exemplary hybrid hydrogels being formed of a plurality of aromatic dipeptides and hyaluronic acid. The hybrid hydrogels are characterized by controllable mechanical and biological properties which can be adjusted by controlling the concentration ratio of the peptides and the polymer, and which average the mechanical and biological properties of the peptides and the polymer. Processes of preparing the hydrogels and uses thereof in pharmaceutical, cosmetic or cosmeceutic applications such as tissue engineering and/or regeneration are further disclosed.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: April 2, 2019
    Assignee: Technology Innovation Momentum Fund (Israel) Limited Partnership
    Inventors: Moran Aviv, Ludmila Buzhansky, Shmuel Einav, Zvi Nevo, Ehud Gazit, Lihi Adler-Abramovich
  • Publication number: 20190054035
    Abstract: Provided are peptide-based nanostructures, as well as diagnostic and therapeutic methods using same.
    Type: Application
    Filed: April 10, 2018
    Publication date: February 21, 2019
    Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., Ramot at Tel-Aviv University Ltd.
    Inventors: Galia BLUM, Yael BEN-NUN, Ehud GAZIT, Lihi ADLER-ABRAMOVICH, Galit FICHMAN
  • Publication number: 20180298062
    Abstract: Ordered structures composed of a plurality of self-assembled peptide nucleic acid (PNA) monomers, and processes of generating same are provided. The plurality of PNA monomers includes modified PNA monomers which are N-protected PNA monomers and/or which feature at least one aromatic moiety attached to a backbone, a nucleobase and/or a nucleobase linkage unit of the PNA monomer. Tunable photonic crystals formed of the provided ordered structures, uses thereof and articles-of-manufacturing containing same are also provided.
    Type: Application
    Filed: October 19, 2016
    Publication date: October 18, 2018
    Inventors: Or BERGER, Lihi ADLER-ABRAMOVICH, Ehud GAZIT
  • Patent number: 10086354
    Abstract: A nanostructure array is disclosed. The nanostructure array comprises a plurality of elongated organic nanostructures arranged generally perpendicularly to a plane.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: October 2, 2018
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Ehud Gazit, Meital Reches
  • Patent number: 10004828
    Abstract: Novel peptide-based hydrogels, composed of short aromatic peptides (e.g., homodipeptides of aromatic amino acid residues) are disclosed. The hydrogels are characterized by remarkable rigidity and biocompatibility. Further disclosed are uses of these hydrogels in applications such as tissue engineering, drug delivery, cosmetics, implantation, packaging and the like. Further disclosed are processes and kits for preparing these hydrogels.
    Type: Grant
    Filed: October 15, 2006
    Date of Patent: June 26, 2018
    Assignee: Romat at Tel-Aviv University Ltd.
    Inventors: Ehud Gazit, Assaf Mahler, Meital Reches
  • Publication number: 20170309842
    Abstract: Ordered (e.g., self-assembled) structures, arranged from peptide nucleic acids and/or analogs thereof, are disclosed. The peptide nucleic acids forming the ordered structures comprise from 1 to 10 PNA backbone units, at least one comprising a guanine nucleobase or an analog thereof. Processes of generating the ordered structures, uses thereof and articles-of manufacturing, devices and systems containing same are also disclosed.
    Type: Application
    Filed: July 13, 2017
    Publication date: October 26, 2017
    Applicant: Technology Innovation Momentum Fund (Israel) Limited Partnership
    Inventors: Or BERGER, Lihi ADLER-ABRAMOVICH, Ehud GAZIT
  • Publication number: 20170298113
    Abstract: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.
    Type: Application
    Filed: September 10, 2015
    Publication date: October 19, 2017
    Inventors: Genady KOSTENICH, Mor ORON-HERMAN, Arie ORENSTEIN, Talia SHEKHTER ZAHAVI, Ehud GAZIT, Yoseph SALITRA, Ludmila BUZHANSKY
  • Patent number: 9790254
    Abstract: Nanostructures made up from two or more types of short peptides (e.g., aromatic dipeptides), which differ from one another by the presence (or absence) of an end-capping moiety, are disclosed. The disclosed nanostructures exhibit a closed tubular structure, short average length and narrow length distribution. Also disclosed are processes of preparing the nanostructures, articles comprising the nanostructures, and use of the nanostructures in, for example, reinforcement of materials.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: October 17, 2017
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Pini Marco, Lihi Adler-Abramovich, Ehud Gazit
  • Patent number: 9741948
    Abstract: Ordered (e.g., self-assembled) structures, arranged from peptide nucleic acids and/or analogs thereof, are disclosed. The peptide nucleic acids forming the ordered structures comprise from 1 to 10 PNA backbone units, at least one comprising a guanine nucleobase or an analog thereof. Processes of generating the ordered structures, uses thereof and articles-of manufacturing, devices and systems containing same are also disclosed.
    Type: Grant
    Filed: May 1, 2014
    Date of Patent: August 22, 2017
    Assignee: Technology Innovation Momentum Fund (Israel) Limited Partnership
    Inventors: Or Berger, Lihi Adler-Abramovich, Ehud Gazit
  • Publication number: 20170209845
    Abstract: A nanostructure array is disclosed. The nanostructure array comprises a plurality of elongated organic nanostructures arranged generally perpendicularly to a plane.
    Type: Application
    Filed: April 10, 2017
    Publication date: July 27, 2017
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Ehud GAZIT, Meital RECHES
  • Publication number: 20170198021
    Abstract: A composition of matter is disclosed which comprises isolated oligomers of human islet amyloid polypeptide (IAPP). Antibodies recognizing same are also disclosed. Use of the composition of matter and the antibodies are also disclosed.
    Type: Application
    Filed: March 16, 2017
    Publication date: July 13, 2017
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Yaron BRAM, Ehud GAZIT
  • Publication number: 20170189582
    Abstract: Hybrid hydrogels formed of a plurality of peptides that are capable of self-assembling into a hydrogel in an aqueous solution and a biocompatible polymer that is characterized by high swelling capability, high elasticity and low mechanical strength are disclosed, with exemplary hybrid hydrogels being formed of a plurality of aromatic dipeptides and hyaluronic acid. The hybrid hydrogels are characterized by controllable mechanical and biological properties which can be adjusted by controlling the concentration ratio of the peptides and the polymer, and which average the mechanical and biological properties of the peptides and the polymer. Processes of preparing the hydrogels and uses thereof in pharmaceutical, cosmetic or cosmeceutic applications such as tissue engineering and/or regeneration are further disclosed.
    Type: Application
    Filed: March 20, 2017
    Publication date: July 6, 2017
    Applicant: Technology Innovation Momentum Fund (Israel) Limited Partnership
    Inventors: Moran AVIV, Ludmila BUZHANSKY, Shmuel EINAV, Zvi NEVO, Ehud GAZIT, Lihi ADLER-ABRAMOVICH
  • Patent number: 9630989
    Abstract: Dipeptide analogs comprising a tryptophan (Trp) moiety coupled to a beta-sheet breaker moiety derived from alpha-aminoisobutyric acid (Aib) are disclosed. The dipeptide analogs exhibit an improved performance in inhibiting amyloid fibril formation, as compared to previously described dipeptides. Compositions containing the dipetide analogs and uses thereof in treating amyloid-associated diseases and disorders are also disclosed.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: April 25, 2017
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Ehud Gazit, Yaniv Amir, Ludmila Buzhansky, Ulrich Abel, Anat Frydman-Marom
  • Patent number: 9624285
    Abstract: A composition of matter is disclosed which comprises isolated oligomers of human islet amyloid polypeptide (IAPP). Antibodies recognizing same are also disclosed. Use of the composition of matter and the antibodies are also disclosed.
    Type: Grant
    Filed: June 2, 2011
    Date of Patent: April 18, 2017
    Assignee: Ramot a Tel-Aviv University Ltd.
    Inventors: Yaron Bram, Ehud Gazit
  • Patent number: 9610353
    Abstract: Hybrid hydrogels formed of a plurality of peptides that are capable of self-assembling into a hydrogel in an aqueous solution and a biocompatible polymer that is characterized by high swelling capability, high elasticity and low mechanical strength are disclosed, with exemplary hybrid hydrogels being formed of a plurality of aromatic dipeptides and hyaluronic acid. The hybrid hydrogels are characterized by controllable mechanical and biological properties which can be adjusted by controlling the concentration ratio of the peptides and the polymer, and which average the mechanical and biological properties of the peptides and the polymer. Processes of preparing the hydrogels and uses thereof in pharmaceutical, cosmetic or cosmeceutic applications such as tissue engineering and/or regeneration are further disclosed.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: April 4, 2017
    Assignee: Technology Innovation Momentum Fund (Israel) Limited Partnership
    Inventors: Moran Aviv, Ludmila Buzhansky, Shmuel Einav, Zvi Nevo, Ehud Gazit, Lihi Adler-Abramovich
  • Publication number: 20160326215
    Abstract: Nanostructures made up from two or more types of short peptides (e.g., aromatic dipeptides), which differ from one another by the presence (or absence) of an end-capping moiety, are disclosed. The disclosed nanostructures exhibit a closed tubular structure, short average length and narrow length distribution. Also disclosed are processes of preparing the nanostructures, articles comprising the nanostructures, and use of the nanostructures in, for example, reinforcement of materials.
    Type: Application
    Filed: May 10, 2016
    Publication date: November 10, 2016
    Inventors: Pini MARCU, Lihi ADLER-ABRAMOVICH, Ehud GAZIT