Patents by Inventor Elaine C. Lee

Elaine C. Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of cell proliferation inhibitors
    Patent number: 6710185
    Abstract: The instant invention discloses a process for the synthesis of substituted indole cell proliferation inhibitors.
    Type: Grant
    Filed: September 20, 2001
    Date of Patent: March 23, 2004
    Assignee: Abbott Laboratories
    Inventors: Ashok K. Gupta, Steven A. King, Elaine C. Lee, Howard E. Morton, Daniel J. Plata, Yu-Ming Pu, Padam N. Sharma
  • Process for the preparation of cell proliferation inhibitors
    Publication number: 20030078439
    Abstract: The instant invention discloses a process for the synthesis of substituted indole cell proliferation inhibitors.
    Type: Application
    Filed: September 20, 2001
    Publication date: April 24, 2003
    Inventors: Ashok K. Gupta, Steven A. King, Elaine C. Lee, Howard E. Morton, Daniel J. Plata, Yu-Ming Pu, Padam N. Sharma
  • Process for preparing 6-o-substituted erythromycin derivatives
    Patent number: 6437106
    Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2′-substituted and optionally 4″-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: August 20, 2002
    Assignee: Abbott Laboratories
    Inventors: Eric J. Stoner, Matthew J. Peterson, Yi-Yin Ku, Russell D. Cink, Arthur J. Cooper, Mahendra N. Deshpande, Tim Grieme, Anthony R. Haight, David R. Hill, Margaret Chi-Ping Hsu, Steven A. King, Marvin Robert Leanna, Elaine C. Lee, Maureen A. McLaughlin, Howard E. Morton, James J. Napier, Daniel J. Plata, Prasad S. Raje, Michael Rasmussen, David Riley, Jien-Heh J. Tien, Steven J. Wittenberger
  • Process for the preparation of 6-O-methyl erythromycin a using 9-hydroxy erythromycin derivatives
    Patent number: 5892008
    Abstract: The claimed invention provides a novel method of preparing 6-O-methyl erythromycin A. The process comprises the steps of reducing the 9-keto group of erythromycin A to form a 9-hydroxy erythromycin A, protecting the 9-, 2'-, and/or 4"-hydroxyl groups of erythromycin A, selectively methylating the 6-position of the 9-hydroxy erythromycin A derivative, deprotecting the hydroxyl groups and oxidizing the 9-hydroxyl to afford 6-O-methyl erythromycin A.
    Type: Grant
    Filed: December 16, 1997
    Date of Patent: April 6, 1999
    Assignee: Abbott Laboratories
    Inventors: Yi-Yin Ku, David A. Riley, Elaine C. Lee, Jien-Heh Tien
  • Use of synthetic metalloporphyrins for preparation and prediction of drug metabolites
    Patent number: 5760216
    Abstract: A method for the systematic and efficient synthetic preparation and identification of metabolites of a pharmaceutical product in order to study possible toxic and/or otherwise biologically-active metabolites of such pharmaceutical products as early and conveniently as possible in the very expensive drug development process, comprising adding samples of the pharmaceutical product to a series of combinations of a synthetic metalloporphyrin (SMP) with a synthetic metalloporphyrin-co-oxidizing reagent in the presence of a suitable solvent, under specified conditions, in a manner such that each sample of pharmaceutical product is reacted with a different combination of synthetic metalloporphyrin, SMP-co-oxidizing reagent and solvent, followed by separation and isolation of the resulting oxidative products, then confirmation of the identity of metabolites from the pre-identified oxidative products by appropriate animal model studies, and subjecting the actual metabolites prepared in larger quantities by the above m
    Type: Grant
    Filed: September 12, 1995
    Date of Patent: June 2, 1998
    Assignee: Abbott Laboratories
    Inventors: Mukund S. Chorghade, David H. Dolphin, David R. Hill, Fumio Hino, Elaine C. Lee