Patents by Inventor Elena N. Komkova

Elena N. Komkova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11554361
    Abstract: Described are composite materials and methods of using them for mixed-mode chromatography. In certain embodiments, the composite material comprises a support member, comprising a plurality of pores extending through the support member; and a multi-functional cross-linked gel. The multi-functional cross-linked gel possesses at least two of the following functions or characteristics: cationic, anionic, hydrophobic, hydrophilic, thiophilic, hydrogen bond donating, hydrogen bond accepting, pi-pi bond donating, pi-pi bond accepting, or metal chelating. The composite materials may be used in the separation or purification of a biological molecule or biological ion.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: January 17, 2023
    Assignee: Merck Millipore Ltd.
    Inventors: Elena N. Komkova, Charles H. Honeyman
  • Publication number: 20220410076
    Abstract: Disclosed are methods for coupling a ligand to a composite material. Covalent bonds are formed between functionalized composite materials and ligands as a ligand solution flows through or across the composite materials. The composite materials are useful as chromatographic separation media.
    Type: Application
    Filed: November 20, 2020
    Publication date: December 29, 2022
    Inventors: Matthew T. Stone, Santosh Rahane, Joaquin A. Umana, Gary Skarja, Elena N. Komkova, Melissa Vandersluis, Amro Ragheb
  • Publication number: 20180353939
    Abstract: Described are composite materials and methods of using them for mixed-mode chromatography. In certain embodiments, the composite material comprises a support member, comprising a plurality of pores extending through the support member; and a multi-functional cross-linked gel. The multi-functional cross-linked gel possesses at least two of the following functions or characteristics: cationic, anionic, hydrophobic, hydrophilic, thiophilic, hydrogen bond donating, hydrogen bond accepting, pi-pi bond donating, pi-pi bond accepting, or metal chelating. The composite materials may be used in the separation or purification of a biological molecule or biological ion.
    Type: Application
    Filed: August 6, 2018
    Publication date: December 13, 2018
    Inventors: Elena N. Komkova, Charles H. Honeyman
  • Publication number: 20180318773
    Abstract: Disclosed is a composite material comprising a support member that has a plurality of pores extending therethrough, which pores are durably filled or coated with a non-crosslinked gel polymer. Also disclosed is a process for the preparation of the composite material, use of the composite material as a separation medium, and a filtering apparatus comprising the composite material.
    Type: Application
    Filed: May 2, 2018
    Publication date: November 8, 2018
    Inventors: Ronald F. Childs, Elena N. Komkova, Jinsheng Zhou, Alicja M. Mika, Tapan K. Dey
  • Publication number: 20140238935
    Abstract: Described are composite materials and methods of using them for mixed-mode chromatography. In certain embodiments, the composite material comprises a support member, comprising a plurality of pores extending through the support member; and a multi-functional cross-linked gel. The multi-functional cross-linked gel possesses at least two of the following functions or characteristics: cationic, anionic, hydrophobic, hydrophilic, thiophilic, hydrogen bond donating, hydrogen bond accepting, pi-pi bond donating, pi-pi bond accepting, or metal chelating. The composite materials may be used in the separation or purification of a biological molecule or biological ion.
    Type: Application
    Filed: February 26, 2014
    Publication date: August 28, 2014
    Applicant: Natrix Separations Inc.
    Inventors: Elena N. Komkova, Charles H. Honeyman
  • Patent number: 8652849
    Abstract: This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.
    Type: Grant
    Filed: October 14, 2008
    Date of Patent: February 18, 2014
    Assignee: Natrix Separations Inc.
    Inventors: Ronald F. Childs, Carlos Filipe, Raja Ghosh, Alicja M. Mika, Jinsheng Zhou, Elena N. Komkova, Marcus Y. Kim, Tapan K. Dey
  • Patent number: 8383782
    Abstract: This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.
    Type: Grant
    Filed: October 30, 2009
    Date of Patent: February 26, 2013
    Assignee: Natrix Separations Inc.
    Inventors: Ronald F. Childs, Carlos Filipe, Raja Ghosh, Jinsheng Zhou, Elena N. Komkova, Marcus Y. Kim, Tapan K. Dey
  • Patent number: 8367809
    Abstract: This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.
    Type: Grant
    Filed: October 30, 2009
    Date of Patent: February 5, 2013
    Assignee: Natrix Separations Inc.
    Inventors: Ronald F. Childs, Carlos Filipe, Raja Ghosh, Jinsheng Zhou, Elena N. Komkova, Marcus Y. Kim, Tapan K. Dey
  • Patent number: 8313651
    Abstract: The present invention discloses a membrane stack comprising a first and second membrane layers, and a spacer layer disposed between said first and second membrane layers, said membrane stack configured such that fluid passes through said membrane stack in a direction substantially perpendicular to the plane of said membrane layers and said spacer layer. The application also discloses a module comprising a membrane as described above, said module having a fluid flow path that is substantially perpendicular to the plane of the major surface of the membrane and spacer layers ins aid membrane stack.
    Type: Grant
    Filed: June 27, 2011
    Date of Patent: November 20, 2012
    Assignee: Natrix Separations Inc.
    Inventors: Ronald F. Childs, Elena N. Komkova, Donna Lisa Crossley, Alicja M. Mika
  • Patent number: 8211682
    Abstract: This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: July 3, 2012
    Assignee: Natrix Separations Inc.
    Inventors: Ronald F. Childs, Carlos Filipe, Raja Ghosh, Alicja M. Mika, Jinsheng Zhou, Elena N. Komkova, Marcus Y. Kim, Tapan K. Dey
  • Patent number: 8206958
    Abstract: This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.
    Type: Grant
    Filed: December 5, 2007
    Date of Patent: June 26, 2012
    Assignee: Natrix Separations Inc.
    Inventors: Ronald F. Childs, Tapan K. Dey, Carlos Filipe, Raja Ghosh, Marcus Y. Kim, Elena N. Komkova, Alicja M. Mika, Jinsheng Zhou
  • Patent number: 8206982
    Abstract: This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.
    Type: Grant
    Filed: October 14, 2008
    Date of Patent: June 26, 2012
    Assignee: Natrix Separations Inc.
    Inventors: Ronald F. Childs, Carlos Filipe, Raja Ghosh, Alicja M. Mika, Jinsheng Zhou, Elena N. Komkova, Marcus Y. Kim, Tapan K. Dey
  • Patent number: 8192971
    Abstract: This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.
    Type: Grant
    Filed: September 16, 2008
    Date of Patent: June 5, 2012
    Assignee: Natrix Separations Inc.
    Inventors: Ronald F. Childs, Carlos Filipe, Raja Ghosh, Alicja M. Mika, Jinsheng Zhou, Elena N. Komkova, Marcus Y. Kim, Tapan K. Dey
  • Patent number: 8187880
    Abstract: This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.
    Type: Grant
    Filed: April 23, 2008
    Date of Patent: May 29, 2012
    Assignee: Natrix Separations, Inc.
    Inventors: Ronald F. Childs, Carlos Filipe, Raja Ghosh, Alicja M. Mika, Jinsheng Zhou, Elena N. Komkova, Marcus Y. Kim, Tapan K. Dey
  • Patent number: 8182694
    Abstract: The present application discloses a membrane stack comprising a first and second membrane layers, and a spacer layer disposed between said first and second membrane layers, said membrane stack configured such that fluid passes through said membrane stack in a direction substantially perpendicular to the plane of said membrane layers and said spacer layer. The application also discloses a module comprising a membrane as described above, said module having a fluid flow path that is substantially perpendicular to the plane of the major surface of the membrane and spacer layers in said membrane stack.
    Type: Grant
    Filed: April 7, 2005
    Date of Patent: May 22, 2012
    Assignee: Natrix Separations Inc.
    Inventors: Ronald F. Childs, Elena N. Komkova, Alicja M. Mika, Donna Lisa Crossley
  • Publication number: 20120064601
    Abstract: Described herein are composite materials and methods of using them for the separation or purification of enantiomers. In certain embodiments, the composite material comprises a support member, comprising a plurality of pores extending through the support member; and a macroporous cross-linked gel, comprising a plurality of macropores, and a plurality of pendant chiral moieties. In certain embodiments, the composite materials may be used in the separation or purification of a chiral small molecule.
    Type: Application
    Filed: September 13, 2011
    Publication date: March 15, 2012
    Inventors: Elena N. Komkova, Amro Ragheb, Charles H. Honeyman
  • Publication number: 20110253616
    Abstract: The present invention discloses a membrane stack comprising a first and second membrane layers, and a spacer layer disposed between said first and second membrane layers, said membrane stack configured such that fluid passes through said membrane stack in a direction substantially perpendicular to the plane of said membrane layers and said spacer layer. The application also discloses a module comprising a membrane as described above, said module having a fluid flow path that is substantially perpendicular to the plane of the major surface of the membrane and spacer layers ins aid membrane stack.
    Type: Application
    Filed: June 27, 2011
    Publication date: October 20, 2011
    Applicant: Natrix Separations Inc.
    Inventors: Ronald F. Childs, Elena N. Komkova, Lisa Crossley, Alicja M. Mika
  • Publication number: 20110117626
    Abstract: Described herein are composite materials and methods of using them for hydrophobic interaction chromatography (HIC). In certain embodiments, the composite material comprises a support member, comprising a plurality of pores extending through the support member; and a macroporous cross-linked gel, comprising a plurality of macropores, and a plurality of pendant hydrophobic moieties. In certain embodiments, the composite materials may be used in the separation or purification of a biological molecule or biological ion.
    Type: Application
    Filed: November 15, 2010
    Publication date: May 19, 2011
    Inventors: Elena N. Komkova, Alicja M. Mika, Marianne Pankratz
  • Patent number: 7883767
    Abstract: A composite material comprising a support member that has a plurality of pores extending therethrough, a first polymer which durably coats the pores of the support member, the first polymer layer having both hydrophobic and hydrophilic properties, and a second polymer layer disposed on the surface of the first polymer layer, the second polymer being more hydrophilic than the first polymer layer. A process for preparing the composite material, and its use as a separation medium.
    Type: Grant
    Filed: September 29, 2005
    Date of Patent: February 8, 2011
    Assignee: McMaster University
    Inventors: Ronald F. Childs, Tapan K. Dey, Elena N. Komkova
  • Publication number: 20100044316
    Abstract: This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.
    Type: Application
    Filed: October 30, 2009
    Publication date: February 25, 2010
    Inventors: Ronald F. Childs, Carlos Filipe, Raja Ghosh, Alicja M. Mika, Jinsheng Zhou, Elena N. Komkova, Marcus Y. Kim, Tapan K. Dey