Patents by Inventor Eli N. Glezer

Eli N. Glezer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MULTIOMIC ANALYSIS DEVICE AND METHODS OF USE THEREOF
    Publication number: 20230088043
    Abstract: Disclosed herein, inter alia, are devices, compositions, kits, and methods for interrogating biological samples.
    Type: Application
    Filed: September 30, 2022
    Publication date: March 23, 2023
    Inventors: Sandor Kovacs, Eli N. Glezer, Christopher Frye
  • METHODS AND COMPOSITIONS FOR SEQUENCING COMPLEMENTARY POLYNUCLEOTIDES
    Publication number: 20230086385
    Abstract: Disclosed herein, inter alia, are substrates, kits, and efficient methods of preparing and sequencing two or more regions of a double-stranded polynucleotide.
    Type: Application
    Filed: September 22, 2022
    Publication date: March 23, 2023
    Inventors: Daan WITTERS, Eli N. GLEZER, Allen LIPSON
  • FLOW CELL RECEIVER AND METHODS OF USE
    Publication number: 20230070067
    Abstract: The present disclosure relates to a flow cell receiver. The flow cell receiver can include at least one platen, having a plurality of ports. The flow cell receiver can include magnets. The flow cell receiver can be configured to automatically align, secure, and retain a flow cell carrier containing a flow cell.
    Type: Application
    Filed: October 11, 2022
    Publication date: March 9, 2023
    Inventors: Sandor Kovacs, David Baranson, Eli N. Glezer
  • Biodosimetry panels and methods
    Patent number: 11600373
    Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: March 7, 2023
    Assignees: MESO SCALE TECHNOLOGIES, LLC., THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
    Inventors: William F. Blakely, Eli N. Glezer, John Kenten, Sudeep Kumar, Anu Mathew, Natalia I. Ossetrova, George Sigal
  • High density sequencing and multiplexed priming
    Patent number: 11578320
    Abstract: Disclosed herein, inter alia, are methods and compositions for sequencing a plurality of template nucleic acids.
    Type: Grant
    Filed: April 27, 2022
    Date of Patent: February 14, 2023
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Eli N. Glezer, Daan Witters, Niek Van Wietmarschen
  • METHODS FOR EVALUATION OF THE EFFECTIVENESS OF A DRUG OR DRUG CANDIDATE IN TREATING AN INFLAMMATORY BOWEL DISEASE BY USE OF A MULTIPLEXED ASSAY KIT COMPRISING VARIOUS BIOMARKERS
    Publication number: 20230038393
    Abstract: Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient’s treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.
    Type: Application
    Filed: April 14, 2022
    Publication date: February 9, 2023
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Jeff D. Debad, Eli N. Glezer, Sudeep M. Kumar
  • Polynucleotide Barcodes for Multiplexed Proteomics
    Publication number: 20230028163
    Abstract: Provided herein are methods for enhanced specificity of multiplexed measurements. Methods provided herein include immunoassay reactions and/or measuring protein-protein interactions with direct sequencing readouts of DNA barcodes.
    Type: Application
    Filed: October 5, 2022
    Publication date: January 26, 2023
    Inventor: Eli N. GLEZER
  • NUCLEOTIDE ANALOGUES
    Publication number: 20230028359
    Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
    Type: Application
    Filed: October 24, 2019
    Publication date: January 26, 2023
    Inventors: Ronald Graham, Olga Adelfinskaya, Megha Cila, Rodrigo Rodriguez, Abrehet Abdu, Eli N. Glezer
  • Methods and compositions for sequencing complementary polynucleotides
    Patent number: 11560590
    Abstract: Disclosed herein, inter alia, are substrates, kits, and efficient methods of preparing and sequencing two or more regions of a double-stranded polynucleotide.
    Type: Grant
    Filed: June 14, 2022
    Date of Patent: January 24, 2023
    Assignee: SINGULAR GENOMICS SYSTEMS, INC.
    Inventors: Daan Witters, Eli N. Glezer, Allen Lipson
  • MODIFIED ARCHAEAL FAMILY B POLYMERASES
    Publication number: 20230011240
    Abstract: Provided herein are modified Archaeal family B polymerases derived from the Archaeal microorganism Pyrococcus-abyssi that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.
    Type: Application
    Filed: September 11, 2019
    Publication date: January 12, 2023
    Inventors: Carl W. FULLER, Eli N. GLEZER, Andrew SPAVENTA, Souad NAJI
  • METHODS FOR IN SITU TRANSCRIPTOMICS AND PROTEOMICS
    Publication number: 20220403457
    Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a cell.
    Type: Application
    Filed: August 2, 2022
    Publication date: December 22, 2022
    Inventors: Eli N. GLEZER, Hu CANG, Zhenmin HONG
  • SPATIAL SEQUENCING
    Publication number: 20220403456
    Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a sample comprising a cell.
    Type: Application
    Filed: July 27, 2022
    Publication date: December 22, 2022
    Inventor: Eli N. Glezer
  • NANOARRAYS AND METHODS OF USE THEREOF
    Publication number: 20220396834
    Abstract: Disclosed herein, inter alia, are nanoarrays and methods of use thereof.
    Type: Application
    Filed: August 5, 2022
    Publication date: December 15, 2022
    Inventors: Eli N. Glezer, Vahid Karimkhani, Shahed Kay, Mohammad Vatankhah Varnosfaderani, Daan Witters
  • Assay kits
    Patent number: 11525825
    Abstract: The present invention is directed to kits for improving assay specificity and performance in binding assays.
    Type: Grant
    Filed: September 9, 2019
    Date of Patent: December 13, 2022
    Assignee: MESO SCALE TECHNOLOGIES, LLC.
    Inventors: Anahit Aghvanyan, Eli N. Glezer, John Kenten, George Sigal, Martin Stengelin, David Routenberg
  • DIAGNOSTIC METHODS FOR INFLAMMATORY DISORDERS
    Publication number: 20220390469
    Abstract: The present invention relates to methods of diagnosing an inflammatory disorder in a patient, as well as methods of monitoring the progression of an inflammatory disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
    Type: Application
    Filed: August 18, 2022
    Publication date: December 8, 2022
    Applicant: Meso Scale Technologies, LLC.
    Inventors: Jeffrey Debad, Eli N. Glezer, Sudeep Kumar
  • Linked paired strand sequencing
    Patent number: 11519029
    Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.
    Type: Grant
    Filed: May 29, 2022
    Date of Patent: December 6, 2022
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Eli N. Glezer, Martin Maria Fabani, Sabrina Shore, Daan Witters
  • Modified thermoccocus polymerases
    Patent number: 11512295
    Abstract: Provided herein are modified Archaeal family B polymerases derived from the Archaeal microorganism Thermococcus sp. EP1 that exhibit improved incorporation of nucleotide analogues utilized in DNA sequences.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: November 29, 2022
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Souad Naji, Carl W. Fuller, Eli N. Glezer, Andrew Spaventa
  • Wash bottle
    Patent number: D970748
    Type: Grant
    Filed: May 5, 2022
    Date of Patent: November 22, 2022
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele Jeffrey-Coker, Eli N. Glezer, Anson Hsu, Cory Spivey
  • Reagent cartridge
    Patent number: D979093
    Type: Grant
    Filed: May 5, 2022
    Date of Patent: February 21, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele Jeffrey-Coker, Eli N. Glezer, Anson Hsu, Cory Spivey
  • Sample cartridge
    Patent number: D981591
    Type: Grant
    Filed: May 5, 2022
    Date of Patent: March 21, 2023
    Assignee: Singular Genomics Systems, Inc.
    Inventors: Bandele Jeffrey-Coker, Eli N. Glezer, Anson Hsu, Cory Spivey